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1.
BMC Med Educ ; 23(1): 89, 2023 Feb 04.
Artículo en Inglés | MEDLINE | ID: mdl-36739393

RESUMEN

BACKGROUND: Clinical management to maintain or restore oral health through the use of drugs during pregnancy is crucial, since at this stage physiological changes significantly influence the absorption, distribution and elimination of the drug, considering also that excessive administration of drugs during this period may have adverse effects on the mother and/or fetus. Therefore, the aim of the present study was to evaluate the factors associated with knowledge of pharmacological management of pregnant women in dental students of a Peruvian university located in the capital and province. METHODS: This analytical, cross-sectional, prospective and observational study assessed 312 Peruvian dental students from third to fifth year of study between February and April 2022. A validated questionnaire of 10 closed questions was used to measure knowledge about pharmacological management in pregnant women. A logit model was used to assess the influence of the variables: gender, age, year of study, marital status, place of origin and area of residence. A significance of p < 0.05 was considered. RESULTS: The 25.96, 55.13 and 18.91% of the dental students showed poor, fair and good knowledge about pharmacological management in pregnant women; respectively. In addition, it was observed that students under 24 years of age and those from the capital were significantly (p < 0.05) 44% less likely to have poor knowledge of pharmacological management in pregnant women compared to those aged 24 years or older (OR = 0.56; CI: 0.34-0.92) and those from the province (OR = 0.56; CI: 0.32-0.98); respectively. Finally, those in their third and fourth year of study were significantly three times more likely to have poor knowledge (OR = 3.17; CI: 1.68-5.97 and OR = 3.88; CI: 2.07-7.31; respectively) compared to fifth year dental students. CONCLUSION: The knowledge of dental students about pharmacological management in pregnant women was predominantly of fair level. In addition, it was observed that being under 24 years of age and being from the capital city were protective factors against poor knowledge, while being a third- and fourth-year student was a risk factor. Finally, gender, marital status and area of residence were not influential factors in the level of knowledge.


Asunto(s)
Mujeres Embarazadas , Estudiantes de Odontología , Humanos , Femenino , Embarazo , Adulto Joven , Adulto , Modelos Logísticos , Perú , Estudios Transversales , Estudios Prospectivos , Encuestas y Cuestionarios , Conocimientos, Actitudes y Práctica en Salud
2.
Rev. int. androl. (Internet) ; 20(2): 128-135, abr.-jun. 2022. tab, ilus
Artículo en Español | IBECS | ID: ibc-205411

RESUMEN

Objetivo: El objetivo de este trabajo es analizar los hallazgos en resonancia magnética testicular (RMt) y el tipo histopatológico de las lesiones para determinar qué características relacionadas con las imágenes pueden constituir predictores de malignidad.Materiales y métodos: Se analizaron de manera retrospectiva 46 pacientes con lesiones testiculares, a quienes se evaluó inicialmente con ultrasonido (US) y luego con RMt empleando un equipo de 1,5 teslas. Los estudios de resonancia magnética (RM) fueron analizados por un radiólogo con 8 años de experiencia en RMt. Los hallazgos en las imágenes como el tamaño de la lesión, la intensidad de señal en secuencias T1, T2, y el realce tras la administración de contraste se correlacionaron con el diagnóstico de anatomía patológica (AP). Se estudió la sensibilidad, la especificidad, el valor predictivo positivo (VPP) y el valor predictivo negativo (VPN).Resultados: El realce tras administración de contraste fue el hallazgo de mejor performance con una sensibilidad, especificidad, VPP y VPN de 90 (71-97), 47 (24-71), 74 (56-87) y 73 (40-92), respectivamente. Los resultados para las lesiones hiperintensas, hipointensas o heterogéneas en secuencias ponderadas en T2 y con realce con el contraste endovenoso fueron de 87 (49-84), 47 (44-89), 74 (55-86) y 67 (35-89), respectivamente (sensibilidad, especificidad, VPP y VPN).Conclusión: El hallazgo de una lesión testicular de baja intensidad de señal y/o heterogénea en secuencias T2, con realce con contraste EV representa un valioso predictor de malignidad. Siendo esta última característica la más sensible como predictor de malignidad en las imágenes. (AU)


Purpose: The purpose of our study is to analyze the imaging findings described in MRI and the histopathologic type of testicular lesions to determine which findings are the best predictors of malignancy.Materials and methods: Forty six (46) patients with testicular lesions were initially studied with ultrasound (US) and with testicular MRI (tMRI) on a 1.5-T magnet. MRIs were reviewed by a radiologist with 8 years of experience and imaging findings such as the size of the lesion, the signal intensity in T1, T2 weighted sequences, and the enhancement after endovenous contrast administration, were correlated with the histopathologic diagnosis. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were analyzed.Results: The enhancement after administration of contrast was the finding of better performance with a sensitivity, specificity, PPV and NPV of 90 (71-97), 47 (24-71), 74 (56-87) and 73 (40-92), respectively. Meanwhile, the results for hypointense/heterogeneous lesions in T2 weighted sequences and with enhancement with intravenous contrast were 87 (49-84), 47 (44-89), 74 (55-86) y 67 (35-89), respectively.Conclusion: The finding of a testicular lesion of low signal intensity and heterogeneous in T2 weighted sequences, with IV contrast enhancement represents a valuable predictor of malignancy. The latter being the most sensitive as a predictor of malignancy. (AU)


Asunto(s)
Humanos , Masculino , Adulto Joven , Adulto , Persona de Mediana Edad , Neoplasias Testiculares/diagnóstico por imagen , Espectroscopía de Resonancia Magnética , Testículo , Ultrasonido , Estudios Retrospectivos , Epidemiología Descriptiva
3.
Rev Int Androl ; 20(2): 128-135, 2022.
Artículo en Español | MEDLINE | ID: mdl-35181252

RESUMEN

PURPOSE: The purpose of our study is to analyze the imaging findings described in MRI and the histopathologic type of testicular lesions to determine which findings are the best predictors of malignancy. MATERIALS AND METHODS: Forty six (46) patients with testicular lesions were initially studied with ultrasound (US) and with testicular MRI (tMRI) on a 1.5-T magnet. MRIs were reviewed by a radiologist with 8 years of experience and imaging findings such as the size of the lesion, the signal intensity in T1, T2 weighted sequences, and the enhancement after endovenous contrast administration, were correlated with the histopathologic diagnosis. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were analyzed. RESULTS: The enhancement after administration of contrast was the finding of better performance with a sensitivity, specificity, PPV and NPV of 90 (71-97), 47 (24-71), 74 (56-87) and 73 (40-92), respectively. Meanwhile, the results for hypointense/heterogeneous lesions in T2 weighted sequences and with enhancement with intravenous contrast were 87 (49-84), 47 (44-89), 74 (55-86) y 67 (35-89), respectively. CONCLUSION: The finding of a testicular lesion of low signal intensity and heterogeneous in T2 weighted sequences, with IV contrast enhancement represents a valuable predictor of malignancy. The latter being the most sensitive as a predictor of malignancy.


Asunto(s)
Neoplasias de Células Germinales y Embrionarias , Neoplasias Testiculares , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Sensibilidad y Especificidad , Neoplasias Testiculares/diagnóstico por imagen , Neoplasias Testiculares/patología
4.
Investig. andin ; 18(32)jun. 2016.
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1550322

RESUMEN

Introducción. El objeto de este manuscrito es reflexionar sobre la experiencia de la implementación del programa de prevención de la tuberculosis en el departamento de Nariño en la última década, bajo la estrategia DOTS-TAES (Direct Observerd Treatment Short Course) y tratamiento acortado estrictamente supervisado de la OMS. Metodología. Se realizó una reflexión a partir de documentos y experiencias institucionales, y una revisión narrativa. Resultados. La experiencia en el departamento de Nariño ha permitido reducir significativamente la incidencia de tuberculosis, dado el apoyo internacional y el énfasis en la prevención, mediante esquemas de atención primaria en salud. La intervención más relevante de este programa ha sido contar con un grupo exclusivo de atención a la tuberculosis y el seguimiento a los casos en cada municipio. Conclusión. El programa es novedoso porque difiere de otros, orientados al diagnóstico y tratamiento oportunista; es decir, cuando el paciente consulta enfermo.


Introduction. The purpose of this manuscript was to conduct a reflection on the experience of the implementation of the TB program in the Department of Nariño in the last decade under the DOTS DOTS (Direct Observerd Treatment Short Course) strategy and observed treatment short of WHO. Methodology. It has been made a reflection from documents and institutional experiences, and a narrative review. Results. Experience in the Department of Nariño has significantly reduced the incidence of tuberculosis in the Department of Nariño given international support and emphasis on prevention through schemes primary health care. The most important intervention of this program has been to have an exclusive group of TB care and follow up cases in each municipality. Conclusion. The program is new because it differs from other diagnostic oriented opportunist treatment, i.e. when the patient consults patient.


Introdução. O objetivo deste artigo foi realizar uma reflexão sobre a experiência da implementação do programa de TB no Departamento de Nariño, na última década sob o DOTS DOTS (Directly Observed Treatment Short Course) estratégia e observado o tratamento a curto da OMS. Metodologia. Foi feita uma reflexão a partir de documentos e experiências institucionais e uma revisão narrativa. Resultados. Experiência no Departamento de Nariño reduziu significativamente a incidência de tuberculose no Departamento de Nariño dado apoio internacional e ênfase na prevenção através de sistemas de cuidados de saúde primários. A intervenção mais importante deste programa tem sido a de ter um grupo exclusivo de cuidados de TB e acompanhamento dos casos em cada município. Conclusão. O programa é novo, porque ele difere de outras formas de tratamento oportunista orientada de diagnóstico, isto é, quando o paciente consulta paciente.

5.
Investig. andin. (En línea) ; 18(32): 1581-1592, 2016. tab, graf
Artículo en Español | LILACS, COLNAL | ID: biblio-1562189

RESUMEN

Introducción. El objeto de este manuscrito es reflexionar sobre la experiencia de la implementación del programa de prevención de la tuberculosis en el departamento de Nariño en la última década, bajo la estrategia DOTS-TAES (Direct Observerd Treatment Short Course) y tratamiento acortado estrictamente supervisado de la OMS. Metodología. Se realizó una reflexión a partir de documentos y experiencias institucionales, y una revisión narrativa. Resultados. La experiencia en el departamento de Nariño ha permitido reducir significativamente la incidencia de tuberculosis, dado el apoyo internacional y el énfasis en la prevención, mediante esquemas de atención primaria en salud. La intervención más relevante de este programa ha sido contar con un grupo exclusivo de atención a la tuberculosis y el seguimiento a los casos en cada municipio Conclusión. El programa es novedoso porque difiere de otros, orientados al diagnóstico y tratamiento oportunista; es decir, cuando el paciente consulta enfermo.


Introduction. The purpose of this manuscript is to reflect on the experience of the implementation of the tuberculosis prevention program in the department of Nariño in the last decade, under the strategy DOTS-TAES (Direct Observerd Treatment Short Course) and strictly supervised WHO shortened treatment. Methodology. A reflection was made from documents and experiences and a narrative review. Results. The experience in the department of Nariño has significantly reduced the incidence of tuberculosis, given the international support and emphasis on prevention, through primary health care schemes. The most relevant intervention of this program has been to have an exclusive group of tuberculosis care and case monitoring in each municipality Conclusion. The program is novel because it differs from others, oriented to diagnosis and opportunistic treatment; that is, when the patient consults sick.


Introdução. O objeto deste manuscrito é refletir sobre a experiência da implementação do programa de prevenção da tuberculose no departamento de Nariño na última década, sob a estratégia DOTS-TAES (Direct Observerd Treatment Short Course) e tratamento abreviado rigorosamente supervisionado pela OMS. Metodologia. Realizou-se uma reflexão a partir de documentos e experiências institucionais, e uma revisão narrativa. Resultados. A experiência no departamento de Nariño permitiu reduzir significativamente a incidência de tuberculose, dado o apoio internacional e a ênfase na prevenção, mediante esquemas de atenção primária em saúde. A intervenção mais relevante deste programa foi contar com um grupo exclusivo de atenção à tuberculose e o acompanhamento dos casos em cada município Conclusão. O programa é novo porque difere de outros, orientados ao diagnóstico e tratamento oportunista; ou seja, quando o paciente consulta doente.


Asunto(s)
Humanos
6.
Colomb Med (Cali) ; 45(3): 96-103, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25386034

RESUMEN

OBJECTIVE: This study sought to measure burden of disease and identifies health priorities from the Disability Adjusted Life Years (DALYs) indicator. METHODS: This is the first study on burden of disease for a department in Colombia by using a standardized methodology. By using the. DALYs indicator, burden of disease was identified in the department of Nariño according to the guidelines established by the World Health Organization. RESULTS: The DALYs in the Department of Nariño highlight the emergence of communicable, maternal, perinatal, and nutritional diseases during the first years of life; of accidents and lesions among youth, and non-communicable diseases in older individuals. Also, accidents and lesions are highlighted in men and non-communicable diseases in women. CONCLUSIONS: This study is part of the knowledge management process in the Departmental Health Plan for Nariño - Colombia 2012-2015 and contributes to the system of indicators of the 2012 ten-year public health plan. This research evidences that communicable diseases generate the biggest part of the burden of disease in the Department of Nariño, that DALYs due to non-communicable diseases are on the rise, and that accidents and lesions, especially due to violence are an important cause of DALYs in this region, which is higher than that of the country.


OBJETIVO: Medir la carga de enfermedad e identificar las prioridades de salud a partir del indicador Años de Vida Saludables Perdidos (AVISA). MÉTODOS: Mediante el uso del indicador AVISA, identificar la carga de enfermedad en el departamento de Nariño según la Guía de la Organización Mundial de la Salud. RESULTADOS: Este es el primer estudio de carga de enfermedad de un departamento en Colombia que utiliza una metodología estandarizada. Los AVISA en el Departamento de Nariño destacan la emergencia de las enfermedades transmisibles, maternales, perinatales y nutricionales en los primeros años de vida; de los accidentes y lesiones entre los jóvenes y las enfermedades no trasmisibles en individuos mayores; así como los accidentes y lesiones destacan en los hombres y las enfermedades no transmisibles en las mujeres. CONCLUSIONES: Este estudio es parte del proceso de gestión de conocimiento del Plan de Salud Departamental de Nariño -Colombia 2012-2015 y contribuye al sistema de indicadores del plan decenal de salud pública 2012. Esta investigación evidencia que las enfermedades trasmisibles generan la mayor parte de la carga de enfermedad del Departamento de Nariño, que los AVISA por enfermedades no transmisibles están en ascenso, y que los accidentes y lesiones, especialmente por causa de la violencia son una causa importante de AVISA en esta región, siendo superior a la del país.


Asunto(s)
Costo de Enfermedad , Personas con Discapacidad/estadística & datos numéricos , Prioridades en Salud , Colombia/epidemiología , Enfermedades Transmisibles/epidemiología , Femenino , Indicadores de Salud , Humanos , Masculino , Años de Vida Ajustados por Calidad de Vida , Organización Mundial de la Salud
7.
Colomb. med ; 45(3): 96-103, July-Sept. 2014. ilus, tab
Artículo en Inglés | LILACS | ID: lil-730949

RESUMEN

Objective: This study sought to measure burden of disease and identifies health priorities from the Disability Adjusted Life Years (DALYs) indicator. Methods: By using the DALYs indicator, burden of disease was identified in the department of Nariño according to the guidelines established by the World Health Organization. Results: The DALYs in the Department of Nariño highlight the emergence of communicable, maternal, perinatal, and nutritional diseases during the first years of life; of accidents and lesions among youth, and non-communicable diseases in older individuals. Also, accidents and lesions are highlighted in men and non-communicable diseases in women. Conclusions: This is the first study on burden of disease for a department in Colombia by using a standardized methodology. This study is part of the knowledge management process in the Departmental Health Plan for Nariño - Colombia 2012-2015 and contributes to the system of indicators of the 2012 ten-year public health plan. This research evidences that communicable diseases generate the biggest part of the burden of disease in the Department of Nariño, that DALYs due to non-communicable diseases are on the rise, and that accidents and lesions, especially due to violence are an important cause of DALYs in this region, which is higher than that of the country.


Objetivo: Medir la carga de enfermedad e identificar las prioridades de salud a partir del indicador Años de Vida Saludables Perdidos (AVISA). Métodos: Mediante el uso del indicador AVISA, identificar la carga de enfermedad en el departamento de Nariño según la Guía de la Organización Mundial de la Salud. Resultados: Los AVISA en el Departamento de Nariño destacan la emergencia de las enfermedades transmisibles, maternales, perinatales y nutricionales en los primeros años de vida; de los accidentes y lesiones entre los jóvenes y las enfermedades no transmisibles en individuos mayores; así como los accidentes y lesiones destacan en los hombres y las enfermedades no transmisibles en las mujeres. Conclusiones: Este es el primer estudio de carga de enfermedad de un departamento en Colombia que utiliza una metodología estandarizada. Este estudio es parte del proceso de gestión de conocimiento del Plan de Salud Departamental de Nariño -Colombia 2012-2015 y contribuye al sistema de indicadores del plan decenal de salud pública 2012. Esta investigación evidencia que las enfermedades transmisibles generan la mayor parte de la carga de enfermedad del Departamento de Nariño, que los AVISA por enfermedades no transmisibles están en ascenso, y que los accidentes y lesiones, especialmente por causa de la violencia son una causa importante de AVISA en esta región, siendo superior a la del país.


Asunto(s)
Femenino , Humanos , Masculino , Costo de Enfermedad , Personas con Discapacidad/estadística & datos numéricos , Prioridades en Salud , Colombia/epidemiología , Enfermedades Transmisibles/epidemiología , Indicadores de Salud , Años de Vida Ajustados por Calidad de Vida , Organización Mundial de la Salud
8.
Science ; 335(6069): 698-702, 2012 Feb 10.
Artículo en Inglés | MEDLINE | ID: mdl-22323816

RESUMEN

Inorganic solids are an important class of catalysts that often derive their activity from sparse active sites that are structurally distinct from the inactive bulk. Rationally optimizing activity is therefore beholden to the challenges in studying these active sites in molecular detail. Here, we report a molecule that mimics the structure of the proposed triangular active edge site fragments of molybdenum disulfide (MoS(2)), a widely used industrial catalyst that has shown promise as a low-cost alternative to platinum for electrocatalytic hydrogen production. By leveraging the robust coordination environment of a pentapyridyl ligand, we synthesized and structurally characterized a well-defined Mo(IV)-disulfide complex that, upon electrochemical reduction, can catalytically generate hydrogen from acidic organic media as well as from acidic water.

9.
Rev med isla juventud ; 13(1)2012. tab
Artículo en Español | CUMED | ID: cum-66194

RESUMEN

Se realizó un estudio de tipo descriptivo y corte transversal en el área de salud de Sierra Caballos perteneciente al Policlínico 1 Juan Manuel Páez Inchausti en el período comprendido de Abril 2009-Abril 2010 con el objetivo de Caracterizar el comportamiento de la Hipertensión Arterial en la población objeto de estudio. El universo estuvo constituido por 798 pacientes de 15-69 años de edad, del cual fue seleccionada la muestra constituida por 108 pacientes que correspondió al total de hipertensos. La Hipertensión Arterial predominó en el sexo femenino (69.4por ciento) y en los grupos de pacientes con edades de 45-54 años en un (51.8 por ciento), predominando además el color de la piel (negra) con un 59.2 por ciento. En la población objeto de estudio se detectó que los factores de riesgo que más incidieron fueron: Hábito de fumar con un 66.6 por ciento, el sedentarismo con un 22.2 por ciento y la obesidad fue predominante con un 70,3 por ciento(AU)


A transversal cut and a descriptive type of study was made over the health area of Sierra Caballos which belongs to Juan Manuel Páez Inchausti Polyclinic 1 in a period comprised between April 2009 and April 2010 with the objective to characterize the Hypertension behaviour in the population selected for the study. The universe (the selected group) was made up by 798 patients between 15-69 years of age, from which a sample made up with 108 patients, was selected which corresponded to the total of hypertensive people. “Hypertension “ prevailed in womanhood (females) (69.4 percent) and in the patient groups which ages were between 45-54 it was (51.8 percent), prevailing, besides that, the color of the skin (black) with a 59.2 percent. In the population who was studied it was detected that the risk factors that struck the most were: Smoking habit with a 66.6 percent, sedentary people with a 22.2 percent and obesity was predominant with a 70.3 percent(AU)


Asunto(s)
Humanos , Presión Sanguínea , Hipertensión , Factores de Riesgo , Enfermedad Crónica , Epidemiología Descriptiva , Estudios Transversales
10.
Rev med isla juventud ; 12(2)2011. ilus
Artículo en Español | CUMED | ID: cum-66230

RESUMEN

Recién nacido minúsculo con peso al nacer de 1180 gramos y edad gestacional de 28.4 semanas y estadías de 77 días en el servicio de neonatología sin complicaciones. Solamente presentó pausa respiratoria tratada con cafeína parenteral, no requirió ventilación mecánica y solamente 48 horas de oxígeno por incubadora a 5 litros por minuto a pesar que nació severamente deprimido no presento complicaciones propias de la asfixia al nacer. Todos los complementarios realizados durante su estadía en servicio fueron negativos es el recién nacido minúsculo de menor peso y menor edad gestacional salvado en la Isla de la Juventud(AU)


Minuscule newborn with birth weight of 1180 grams and a gestational age of 28.4 weeks and a permanence of 77 days in the neonatology service without complications. He only presented a respiratory pause treated with parenteral caffeine, he did not required mechanical ventilation and only 48 hours of oxygen per incubator at 5 liters per minute despite he was born severely depressed he does not presented complications of birth asphyxia. All complementary performed during his stay in the service were negative is the minuscule newborn lighter weight and lower gestational age saved on the Isle of Youth(AU)


Asunto(s)
Humanos , Femenino , Recién Nacido , Recién Nacido de Bajo Peso , Complicaciones del Embarazo
11.
Rev med isla juventud ; 12(1)2011. tab
Artículo en Español | CUMED | ID: cum-66214

RESUMEN

Unos de los problemas de salud que aumenta la morbilidad en el servicio de neonatología es el nacimiento de niños macrosómicos, sobre este tema existen pocos estudios en nuestro municipio Isla de la Juventud.Se realizó un estudio retrospectivo descriptivo longitudinal del comportamiento de la macrosomìa fetal en el Hospital Docente Héroes del Baire durante el período comprendido desde el 1ro. de enero de 2008 hasta el 31 de diciembre de 2010; para identificar su incidencia, los antecedentes maternos más frecuentes, valorar la vía del parto y morbimortalidad perinatal. Los datos fueron tomados del libro de partos y de morbilidad del servicio de neonatología. Además de las historias clínicas maternas y de los recién nacidos, procesándose estadísticamente. Se analizaron un total de 254 casos de recién nacidos que pesaron 4000g o más, se encontró una incidencia de macrosomía de un 9 por ciento. Los principales antecedentes maternos fueron: embarazo prolongado (62 por ciento), la obesidad (29 por ciento) y diabetes mellitus familiar (21 por ciento). El tipo de parto que predominó fue el distócico (52 por ciento), la paridad de 1-2 hijos (76 por ciento) y el sexo masculino (67 por ciento). No existió mortalidad perinatal y la complicación que con más frecuencia se encontró fue el traumatismo del parto que represento el 59 por ciento(AU)


Some of the problems of health that the morbidity increases in our neonatology service are the birth of macrosómic´s children about this topic exist a few studies in our Municipality Island of the Youth.It was carried out a longitudinal descriptive retrospective study of the behaviour of the fetal macrosomic in the Hospital Heroes del Baire during the period understood from the 1ro. of January of 2008 up to December 31 the 2010, to identify their incidence, the most frequent maternal antecedents, to value the road of the childbirth and morbidity and mortality per natal. The data were taken of the childbirth book and of mobility of the neonatology service and of the maternal clinical histories and of those recently born ones, and processed statistically. They were analyzed a total of 254 cases whose recently born they weighed 4000g or more, in those that he/she was an incidence of macrosomìc of a (9 percent), as main maternal antecedents: I embarrass lingering a (62 percent), the obesity the (29 percent) and family diabetes (21 percent). The childbirth type that prevailed was the dystocic with a (52 percent), the parity of 1-2 children (76 percent) and the masculine sex the (67 percent).No fetal mortality and the complications that met with more frequency existed the traumatisms of the childbirth that I represent the were (59 percent)(AU)


Asunto(s)
Humanos , Recién Nacido , Macrosomía Fetal , Morbilidad , Indicadores de Morbimortalidad , Epidemiología Descriptiva , Estudios Prospectivos
12.
Inorg Chem ; 49(1): 222-8, 2010 Jan 04.
Artículo en Inglés | MEDLINE | ID: mdl-19957948

RESUMEN

The utility of the 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidinato ligand, (hpp)(-), in uranium chemistry has been probed by synthesizing metallocene complexes and studying their reactivity. (C(5)Me(5))(2)UMe(2) reacts with 1 equiv of Hhpp to form (C(5)Me(5))(2)(hpp)UMe, 1, which does not react further with Hhpp. (C(5)Me(5))(2)UCl(2) reacts with Khpp to form (C(5)Me(5))(2)(hpp)UCl, 2, which similarly does not react with additional Khpp. Complex 2 reacts with NaN(3) to form the azide complex, (C(5)Me(5))(2)(hpp)UN(3), 3. The trivalent uranium (hpp)(-) metallocene complex, (C(5)Me(5))(2)(hpp)U, 4, can be synthesized by the reaction of [(C(5)Me(5))(2)U][BPh(4)] with Khpp and from 2 with KC(8). Complex 4 can be oxidized with Ph(3)P horizontal lineSe to produce the tetravalent product, [(C(5)Me(5))(2)(hpp)U](2)(mu-Se), 5. The reaction of 4 with Me(3)SiN(3) provides the pentavalent uranium complex, (C(5)Me(5))(2)(hpp)U(=NSiMe(3)), 6.

13.
Inorg Chem ; 47(23): 11376-81, 2008 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-18986133

RESUMEN

Reaction of the lanthanide metallocene allyl complexes, (C(5)Me(5))(2)Ln(eta(3)-CH(2)CHCH(2))(THF) (Ln = Ce, Sm, Y) with 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine, Hhpp, forms a series of metallocene complexes, (C(5)Me(5))(2)Ln(hpp) (Ln = Ce, Sm, Y) in which the (hpp)(1-) anion coordinates as a terminal bidentate ligand. Isomorphous structures were observed by X-ray crystallography regardless of the size of the metal. The acetonitrile adduct, (C(5)Me(5))(2)Sm(hpp)(MeCN), was also crystallographically characterized to provide an unusual pair of eight- and nine-coordinate complexes. The coordination mode of the (hpp)(1-) anion in these complexes is compared with that in other heteroallylic metallocenes like the caprolactamate (C(5)Me(5))(2)Y(ONC(6)H(10)) and the dithiocarbamate (C(5)Me(5))(2)Sm(S(2)CNEt(2)), which was also structurally characterized.

14.
J Am Chem Soc ; 130(37): 12258-9, 2008 Sep 17.
Artículo en Inglés | MEDLINE | ID: mdl-18722444

RESUMEN

The U4+ mixed alkyl hydride complex (C5Me5)U[mu-C5Me3(CH2)2](mu-H)2U(C5Me5)2, 1, which contains a cyclopentadienyl ligand with two metalated methylene substituents, can effect four, six, and eight-electron reductions in which the combination of the two H1- ligands and the [C5Me3(CH2)2]3- moiety delivers four electrons and forms (C5Me5)1-. The reaction is formally equivalent to an alkyl hydride reductive elimination, a transformation common with transition metals not previously observed with f element compounds. This type of alkyl hydride reduction reactivity is also observed with a combination of U4+ alkyl and hydride complexes, (C5Me5)2UMe2/[(C5Me5)2UH2]2, which reduces benzene to make [(C5Me5)2U]2(C6H6), a U3+ complex formally containing a (C6H6)2- ligand.

15.
J Am Chem Soc ; 130(1): 16-7, 2008 Jan 09.
Artículo en Inglés | MEDLINE | ID: mdl-18067300

RESUMEN

The reaction of [(C5Me5)2Ln][(mu-Ph)2BPh2] complexes with the lithium salt of (trimethylsilyl)diazomethane, Li[Me3SiCN2], gave products formulated as the dimeric isocyanotrimethylsilyl amide complexes {(C5Me5)2Ln[mu-N(SiMe3)NC]}2 (Ln = Sm, 1; La, 2). Reactions of (C5Me5)2Sm and [(C5Me5)2Sm(mu-H)]2 with Me3SiCHN2 also form 1. Complexes 1 and 2 react with Me3CCN to form the 1,2,3-triazolato complexes (C5Me5)2Ln(NCCMe3)[NNC(SiMe3)C(CMe3)N] (Ln = Sm, 3; La, 4). Complex 2 reacts with Me3SiN3 to make the isocyanide ligated azide complex {(C5Me5)2La[CNN(SiMe3)2](mu-N3)}3, 5.

16.
Rev med isla juventud ; 7(1)2006. tab
Artículo en Español | CUMED | ID: cum-66080

RESUMEN

Teniendo en cuenta que los procesos febriles constituyen una causa frecuente de consulta en la edad pediátrica y que en ocasiones el médico no dispone de recursos confiables para un diagnóstico de certeza, se realizó una revisión del concepto y la clasificación de la fiebre, el problema que constituye la Bacteriemia oculta en los pacientes pediátricos y los pacientes con mayor riesgo de desarrollar una infección bacteriana severa. Se propone un manejo adecuado en nuestro medio, de estos pacientes(AU)


Keeping in mind that the feverish processes are frequent cause of consultation in the pediatric age and in occasions the doctor doesn't have reliable resources for a certain diagnosis, we carried out a revision of the concept and the classification of the fever, the problem that constitutes the hidden bacteriemia in the pediatric patients, the patients with more risk of developing a severe bacterial infection. Its suggest a proper handling in our means for these patients(AU)


Asunto(s)
Humanos , Niño , Fiebre/diagnóstico , Fiebre/complicaciones , Bacteriemia , Niño , Literatura de Revisión como Asunto
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