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1.
Opt Express ; 32(11): 20194-20206, 2024 May 20.
Artículo en Inglés | MEDLINE | ID: mdl-38859135

RESUMEN

In this work, a common-path optical coherence tomography (OCT) system is demonstrated for characterizing the tissue in terms of some optical properties. A negative axicon structure chemically etched inside the fiber tip is employed as optical probe in the OCT. This probe generates a quality Bessel beam owning a large depth-of-field, ∼700 µm and small central spot size, ∼3 µm. The OCT system is probing the sample without using any microscopic lens. For experimental validation, the OCT imaging of chicken tissue has been obtained along with estimation of its refractive index and optical attenuation coefficient. Afterwards, the cancerous tissue is differentiated from the normal tissue based on the OCT imaging, refractive index, and optical attenuation coefficient. The respective tissue samples are collected from the human liver and pancreas. This probe could be a useful tool for endoscopic or minimal-invasive inspection of malignancy inside the tissue either at early-stage or during surgery.


Asunto(s)
Pollos , Tomografía de Coherencia Óptica , Tomografía de Coherencia Óptica/métodos , Tomografía de Coherencia Óptica/instrumentación , Humanos , Animales , Diseño de Equipo , Hígado/diagnóstico por imagen , Hígado/patología , Páncreas/diagnóstico por imagen , Refractometría
2.
Opt Express ; 31(17): 27203-27212, 2023 Aug 14.
Artículo en Inglés | MEDLINE | ID: mdl-37710800

RESUMEN

This paper demonstrates whispering gallery mode (WGM) resonance with the help of an encaved optical nano-probe developed inside an optical fiber tip cavity. The nano-probe generates a tightly focused beam with a spot-size of ∼3 µm. A barium titanate microsphere is placed besides the optical axis inside the cavity. The focused beam remains off-axis of the microresonator and excites the WGM. The off-axis excitation shows unique resonating properties depending on the location of the resonator. A resonant peak with quality factor as high as Q ∼7 × 104 is achieved experimentally. Another design with a shorter cavity length for a bigger resonator is also demonstrated by embedding a bigger microsphere on the cleaved fiber tip surface. The optical probe holds great potential for photonic devices and is ideal for studying morphology-based scattering problems.

3.
Appl Opt ; 62(3): 511-517, 2023 Jan 20.
Artículo en Inglés | MEDLINE | ID: mdl-36821252

RESUMEN

This work presents an optical fiber negative/reflective axicon probe that generates an energy-efficient quasi-Bessel beam (QBB) having a central spot (CS) possessing ∼20% of the QBB power. With silver coating around the axicon, the CS power has been increased by ∼45%. The QBB possesses a large depth of field, ∼400µm, with a micron order spot size as obtained experimentally. The probe has further been explored for common-path optical coherence tomography. The probe length has been optimized to minimize the path length difference between the reference and sample signal. With a divergence angle of just 0.013°, the beam provides a lateral resolution of ∼2.5 to ∼16µm for an axial distance of 0.1 to 1.0 mm. The imaging results are presented for standard samples such as onion and Scotch tape.

4.
Appl Opt ; 61(8): 1958-1964, 2022 Mar 10.
Artículo en Inglés | MEDLINE | ID: mdl-35297887

RESUMEN

This work demonstrates an interferometric technique to measure the refractive index (RI) of microliter volume of biosample solutions with the help of an optical fiber negative axicon and Bessel beam with the micrometer-size central spot. The RI measuring device consists of a broadband superluminescent diode (SLD) source along with an optical circulator and spectrometer. The axicon optical fiber probe packaged with a glass slide is connected to a broadband SLD source through an optical circulator, and a drop of microliter bioliquid sample is placed on the packaged probe's head. The reflected light from the glass-liquid interface couples back to the axicon probe and interferes with the reference beam generated at the air-glass interface of the axicon. The interference spectrum is further analyzed by applying the fast Fourier transform to calculate power from the respective interface and solve the Fresnel equation for the RI measurement. The RI of small sample volume ∼2µl of glucose solutions and bovine serum albumin protein solutions are reported as an application of the proposed method. This sensing platform shows promising applications in biomedicine for monitoring small volume various biosample concentrations. We also demonstrate RI measurement of flowing liquid sample using the developed setup in case the design can be considered for microfluidic channel research.


Asunto(s)
Interferometría , Refractometría , Microfluídica , Fibras Ópticas
5.
Opt Lett ; 47(3): 497-500, 2022 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-35103658

RESUMEN

We demonstrate an all-fiber negative axicon probe with a Bessel beam for low coherence phase microscopy including refractive index measurement of a cellular level sample in reflection mode. The negative axicon chemically incised at the distal end of the optical fiber spawns the Bessel beam. The system provides a phase sensitivity of ∼0.28 mrad and optical path length sensitivity of ∼23 pm in air. The lateral resolution and working distance are found to be ∼3.91 µm and 650 µm to exhibit the performance of the system experimentally. The three-dimensional (3D) phase map of the cheek cell along with the refractive index is obtained from the reflected power spectrum. The combined low coherence phase microscopy and refractive index measurement provides the system with a potential for biological application. Also, the all-fiber probe can be easily integrated as an endoscopic probe.


Asunto(s)
Microscopía , Refractometría , Endoscopía , Fibras Ópticas
6.
Opt Lett ; 44(13): 3386-3389, 2019 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-31259967

RESUMEN

We demonstrate the excitation and detection of whispering gallery modes in optical microresonators using a "point-and-play," fiber-based, optical nano-antenna. The coupling mechanism is based on cavity-enhanced Rayleigh scattering. Collected spectra exhibit Lorentzian dips, Fano shapes, or Lorentzian peaks, with a coupling efficiency around 13%. The spectra are characterized by the coupling gap, polarization, and fiber tip position. The coupling method is simple, low-cost and, most importantly, the Q-factor can be maintained at 108 over a wide coupling range, thereby making it suitable for metrology, sensing, or cavity quantum electrodynamics experiments.

7.
Rev Sci Instrum ; 90(1): 015110, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30709204

RESUMEN

This work demonstrates an interferometric technique to estimate the reflected powers from dielectric interfaces and the reflection coefficient using the Fresnel equation for measurement of the refractive index (RI) of liquid samples. It uses low-coherence common-path optical interferometry that is commonly used for optical imaging. A uniquely designed optical fiber tip generating a high-quality non-diffractive Bessel beam probes liquid samples in a glass container non-invasively. The light reflected from different interfaces of the container is recollected by the same optical fiber tip. The reflected beams interfere with the reference beam generated at the fiber tip itself. This interference spectrum is further processed using fast-Fourier transform to measure reflected powers from the respective interfaces. The acquired powers are used to solve the Fresnel equation to find RI of liquid samples. As a proof of concept, experiments have been performed on several liquid samples including turbid media such as blood. This non-invasive interferometric technique could also be an ideal example confirming the Fresnel equation for reflection of light. Unlike other optical fiber-based RI sensors, this technique does not require temperature compensation. The method can be employed for inspection of the production process in terms of RI in pharmaceutical and chemical process plants, etc.

8.
Appl Opt ; 52(22): 5455-9, 2013 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-23913065

RESUMEN

In this work we present a novel nanomaterial coating technique using evanescent wave (EW). The gradient force in the EW is used as an optical tweezer for tweezing and self-assembling nanoparticles on the source of EW. As a proof of the concept, we have used a laser coupled etched multimode optical fiber, which generates EW for the EW assisted coating. The section-wise etched multimode optical fiber is horizontally and superficially dipped into a silver/gold nanoparticles solution while the laser is switched on. The fiber is left until the solution recedes due to evaporation leaving the fiber in air. The coating time usually takes 40-50 min at room temperature. The scanning electron microscope image shows uniform and thin coating of self-assembled nanoparticles due to EW around the etched section. A coating thickness <200 nm is achieved. The technique could be useful for making surface-plasmon-resonance-based optical fiber probes and other plasmonic circuits.

9.
Opt Lett ; 37(19): 4017-9, 2012 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-23027264

RESUMEN

We propose a simple optical fiber tip for field-enhanced second harmonic generation (SHG). The tip shows nonlinear phenomena of SHG over a wide range of sources, at least from 630 to 830 nm. The optical field corresponding to the second harmonic appears as a nondiffracting bottle beam with voids due to the surface curvature of the tip. The field-enhanced second harmonic can also induce surface plasmons, converting the tip to a plasmonic probe with reduced background signal. The tip can be useful in nanophotonics characterization. As an example, we demonstrate the tip's response as a surface-enhanced Raman spectroscopy probe.

10.
Rev Sci Instrum ; 82(9): 095107, 2011 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-21974619

RESUMEN

We propose a novel refractive index sensor based on multimode microfiber knot-type loop (NL) interferometer. The middle portion (~5 cm) of a 15 cm long multimode fiber is etched in 48% hydrofluoric acid to reduce its diameter to ~12 µm. A NL of diameter <1 mm is made from the etched fiber. The ends of etched fiber are spliced with single-mode fibers for launching and detecting light from the NL interferometer. The NL introduces path differences to produce interferometric spectra with free spectral range ~16 nm. The spectrum shifts as the surrounding refractive index of the loop is changed by adding chemicals. We observe the highest sensitivity of the NL interferometer ~172 nm/RIU (refractive index unit) at a refractive index value 1.370 as obtained experimentally using commonly available chemicals. The design could be used as simple, low cost, and highly sensitive biological and chemical sensor.

11.
Opt Express ; 17(22): 19470-5, 2009 Oct 26.
Artículo en Inglés | MEDLINE | ID: mdl-19997167

RESUMEN

We propose a technique of chemical etching for fabrication of near perfect optical fiber nanoprobe (NNP). It uses photosensitive single mode optical fiber to etch in hydro fluoric (HF) acid solution. The difference in etching rate for cladding and photosensitive core in HF acid solution creates capillary ring along core-cladding boundary under a given condition. The capillary ring is filled with acid solution due to surface tension and capillary action. Finally it creates near perfect symmetric tip at the apex of the fiber as the height of the acid level in capillary ring decreases while width of the ring increases with continuous etching. Typical tip features are short taper length (approximately 4 microm), large cone angle (approximately 38 degrees ), and small probe tip dimension (<100 nm). A finite difference time domain (FDTD) analysis is also presented to compare near field optics of the NNP with conventional nanoprobe (CNP). The probe may be ideal for near field optical imaging and sensor applications.


Asunto(s)
Microscopía de Sonda de Barrido/instrumentación , Nanotecnología/instrumentación , Fibras Ópticas , Transductores , Acción Capilar , Diseño Asistido por Computadora , Diseño de Equipo , Análisis de Falla de Equipo , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Tensión Superficial
12.
Rev Sci Instrum ; 80(10): 103106, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19895053

RESUMEN

A single fiber Bragg grating (FBG) sensor with two sections of different diameters is proposed and experimentally demonstrated for discrimination and measurement of strain and temperature. A section of single FBG is etched in hydrofluoric acid solution to reduce diameter of the fiber by factor of <1/2 to increase its strain sensitivity. Different shifts of the Bragg wavelengths of chemically etched and nonetched gratings caused by different strain sensitivities are used to discriminate and measure strain and temperature. Maximum errors of +/-13 microepsilon (microstrain) and +/-1 degrees C are reported over 1700 microepsilon and 60 degrees C measurement ranges, respectively. Depending upon the diameter of the etched fiber grating, the design can also discriminate nanostrain from temperature.

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