RESUMEN

Liver hydrolysate (LH) is used as a pharmaceutical agent in Japan, to enhance liver function. However, the effects of LH on sickness behavior are unknown. This study investigated the effect of LH on sickness behaviors, such as concanavalin A (ConA)-induced reduction of locomotor activity. ConA treatment significantly decreased locomotor activity. The striatal tyrosine hydroxylase (TH) levels were also significantly decreased following ConA treatment. The decreased locomotor activity and TH levels were significantly reversed by LH treatment. LH may prove beneficial for preventing sickness behavior following ConA treatment, at least in part, by activating TH in the striatum.

Asunto(s)

Concanavalina A/efectos adversos , Conducta de Enfermedad/efectos de los fármacos , Hígado , Actividad Motora/efectos de los fármacos , Trastornos Motores/tratamiento farmacológico , Trastornos Motores/psicología , Hidrolisados de Proteína/farmacología , Hidrolisados de Proteína/uso terapéutico , Animales , Cuerpo Estriado/enzimología , Activación Enzimática/efectos de los fármacos , Masculino , Ratones Endogámicos , Trastornos Motores/inducido químicamente , Trastornos Motores/enzimología , Tirosina 3-Monooxigenasa/metabolismo