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Clin Med (Lond) ; 14(6): 604-7, 2014 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25468844

RESUMEN

Perioperative ß-blocker therapy has been advocated to reduce cardiac mortality and morbidity in high-risk cardiac patients undergoing non-cardiac surgery. Core data that supported this intervention and informed international societal guidelines has recently been withdrawn. A subsequent meta-analysis of the remaining data reporting excess mortality has re-opened the debate about the utility of ß-blocker therapy in the perioperative period. Criticism of remaining trial designs and new insights into the protective mechanisms of ß-blocker therapy in critical illness raise important questions that should now be addressed by a further robust, high-quality randomised control trial.


Asunto(s)
Antagonistas Adrenérgicos beta , Cardiopatías , Atención Perioperativa , Procedimientos Quirúrgicos Operativos/estadística & datos numéricos , Antagonistas Adrenérgicos beta/efectos adversos , Antagonistas Adrenérgicos beta/uso terapéutico , Muerte , Cardiopatías/tratamiento farmacológico , Cardiopatías/mortalidad , Humanos , Atención Perioperativa/métodos , Atención Perioperativa/mortalidad , Riesgo
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