RESUMEN
In this paper we presented characteristics of insulin resistance syndrome (IRS), also known as metabolic syndrome and syndrome X, with an emphasis on insulin resistance in hyperandrogenemic women. The aim features of IRS are obesity, hypertension, dyslipidemia-hypertriglyceridemia and decreased HDL cholesterol, impaired glucose tolerance with hyperinsulinemia and higher cardiovascular morbidity. It is considered typical that in hyperandrogenemia, especially in PCO syndrome, insulin resistance and hyperinsulinemia without other characteristics of IRS are expressed.
Asunto(s)
Hiperandrogenismo/metabolismo , Resistencia a la Insulina , Femenino , Humanos , Síndrome del Ovario Poliquístico/metabolismo , SíndromeRESUMEN
An insulin-related growth-promoting substance was detected in the serum of a patient with Hodgkin's disease who suffered from severe hypoglycaemia, as well as in the supernatant of homogenized spleen tissue of the same patient. Low concentrations of this substance enhanced DNA synthesis of short-term-cultured spleen tumour cells obtained from the same patient, while the addition of anti-insulin antiserum interfered with that effect. Moreover, the preincubation of this insulin-related substance with the anti-insulin antiserum abrogated its stimulatory effect on tumour cell proliferation. Both insulin and the insulin-related substance bound to patients splenocytes to a similar extent. The data suggest that the insulin-related substance, found in this particular case of Hodgkin's disease, plays a role in tumour progression by an autocrine mechanism.
Asunto(s)
Enfermedad de Hodgkin/metabolismo , Somatomedinas/biosíntesis , Glucemia , División Celular/fisiología , Cromatografía por Intercambio Iónico , ADN/biosíntesis , Factores de Crecimiento Endotelial/fisiología , Factor de Crecimiento Epidérmico/fisiología , Factores de Crecimiento de Fibroblastos/fisiología , Humanos , Insulina/metabolismo , Factor I del Crecimiento Similar a la Insulina/fisiología , Masculino , Persona de Mediana Edad , Factor de Crecimiento Derivado de Plaquetas/fisiología , Somatomedinas/aislamiento & purificación , Células Tumorales CultivadasRESUMEN
Daily iodine intake has been investigated in 52 healthy children (5-14 years), 112 healthy adults and in 39 patients with nontoxic goiter from the area of Zagreb/Yugoslavia. Fourteen goitrous patients received 1-thyroxine 150 micrograms daily for at least three months before the examination. Iodine intake has been estimated on the basis of urinary iodine excretion (microgram I-/g creatinine) in the first morning specimen. Iodine excretion in nontreated goitrous patients (92 +/- 30; Mean +/- SD) was significantly lower than in healthy adults (112 +/- 38), while the value in treated goitrous patients (165 +/- 69) was significantly higher than that in nontreated goitrous and healthy adult subjects. The results suggest that Zagreb area, although classified as nonendemic, has borderline iodine intake, and that relative iodine deficiency is of importance in goiter formation. The authors plead for increased daily iodine intake through increased table salt iodisation from actual amount of 10 to 20 to 25 mg KI/kg salt in order to provide an average daily intake of 250 micrograms of iodine.