Asunto(s)
Magnetismo , Blefaroptosis/terapia , Cateterismo/instrumentación , Separación Celular , Colostomía/instrumentación , Embolización Terapéutica/instrumentación , Eritrocitos , Cuerpos Extraños/cirugía , Humanos , Espectroscopía de Resonancia Magnética/instrumentación , Instrumentos QuirúrgicosRESUMEN
A series of methyl imidazo-[11,2-a]pyridine-2-carbamates was synthesized for anthelmintic testing. The preparation of this class of compounds was simplified by utilization of a novel one-step condensation of the appropriately substituted 2-aminopyridine and methyl chloroacetylcarbamate. The most potent compound, methyl 6-(phenylsulfinyl)-imidazo[1,2-a]pyridine-2-carbamate, was orally effective against a broad range of helminths in sheep and cattle, at a dosage of 2.5 mg/kg. Limited trials in swine and dogs demonstrated anthelmintic activity at higher dosages. Limited observations in sheep and cattle indicated that, in both species, a single oral dose of 200 mg/kg was well tolerated.
Asunto(s)
Antihelmínticos/síntesis química , Carbamatos/síntesis química , Piridinas/síntesis química , Animales , Antihelmínticos/uso terapéutico , Carbamatos/farmacología , Carbamatos/uso terapéutico , Bovinos , Perros , Ratones , Infecciones por Nematodos/tratamiento farmacológico , Piridinas/farmacología , Piridinas/uso terapéutico , Ovinos , PorcinosRESUMEN
The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.