1.
Cell Death Dis
; 5: e1266, 2014 May 29.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24874738
RESUMEN
Lipids are key regulators of cell physiology through the control of many aspects of cellular life and survival. In particular, lipids have been implicated at different levels and through many different mechanisms in the cell death program called apoptosis. Here, we discuss the action of lipids in the regulation of the activation and the integration of Bax into the mitochondrial outer membrane, a key pro-apoptotic member of the BCL-2 family. We describe how, during apoptosis, lipids can act simultaneously or in parallel as receptors or ligands for Bax to stimulate or inhibit its pro-death activity.
Asunto(s)
Apoptosis/fisiología , Lípidos de la Membrana/metabolismo , Membranas Mitocondriales/metabolismo , Proteína X Asociada a bcl-2/metabolismo , Animales , Humanos
2.
Arch Pathol
; 85(4): 388-96, 1968 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-4171108