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More than tools for managing physical and digital objects, museum collection management systems (CMS) serve as platforms for structuring, integrating, and making accessible the rich data embodied by natural history collections. Here we describe Arctos, a scalable community solution for managing and publishing global biological, geological, and cultural collections data for research and education. Specific goals are to: (1) Describe the core features and implementation of Arctos for a broad audience with respect to the biodiversity informatics principles that enable high quality research; (2) Highlight the unique aspects of Arctos; (3) Illustrate Arctos as a model for supporting and enhancing the Digital Extended Specimen concept; and (4) Emphasize the role of the Arctos community for improving data discovery and enabling cross-disciplinary, integrative studies within a sustainable governance model. In addition to detailing Arctos as both a community of museum professionals and a collection database platform, we discuss how Arctos achieves its richly annotated data by creating a web of knowledge with deep connections between catalog records and derived or associated data. We also highlight the value of Arctos as an educational resource. Finally, we present the financial model of fiscal sponsorship by a nonprofit organization, implemented in 2022, to ensure the long-term success and sustainability of Arctos.

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Advancement of the scientific enterprise relies on individuals conducting research in an ethical and responsible manner. Educating emergent scholars in the principles of ethics/responsible conduct of research (E/RCR) is therefore critical to ensuring such advancement. The recent impetus to include authentic research opportunities as part of the undergraduate curriculum, via course-based undergraduate research experiences (CUREs), has been shown to increase cognitive and noncognitive student outcomes. Because of these important benefits, CUREs are becoming more common and often constitute the first research experience for many students. However, despite the importance of E/RCR in the research process, we know of few efforts to incorporate E/RCR education into CUREs. The Ethics Network for Course-based Opportunities in Undergraduate Research (ENCOUR) was created to address this concern and promote the integration of E/RCR within CUREs in the biological sciences and related disciplines. During the inaugural ENCOUR meeting, a four-pronged approach was used to develop guidelines for the effective integration of E/RCR in CUREs. This approach included: 1) defining appropriate student learning objectives; 2) identifying relevant curriculum; 3) identifying relevant assessments; and 4) defining key aspects of professional development for CURE facilitators. Meeting outcomes, including the aforementioned E/RCR guidelines, are described herein.

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BACKGROUND: Reconstruction of the frontonaso-orbital complex is one of the best-described and most commonly used procedures in the field of facial feminization surgery. To a large extent, this complex determines the facial expression and plays a key role in the visual identification of facial gender. After the forehead, the hairline pattern is the second most important feature of gender identification within the upper third of the face. The combined evaluation of these two features should be a basic premise of facial feminization surgery. METHODS: The authors present a new surgical sequence developed by their group in which reconstruction of the frontonaso-orbital complex and redefinition of the hairline by means of an autologous hair transplant are carried out during the same operation: forehead reconstruction and simultaneous hair transplantation. RESULTS: Sixty-five male-to-female transgender patients treated with forehead reconstruction and simultaneous hair transplantation are presented along with the surgical technique, sequence used, and the results obtained. A classification method for hairlines in male-to-female transgender patients is proposed based on the observation of 492 patients. A modified temporoparietooccipital coronal (posterior coronal) approach is also described. CONCLUSION: The forehead reconstruction and simultaneous hair transplant technique makes it possible to address the entire upper third of the face in a single facial feminization operation.

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A 14-year-old boy with severe combined immunodeficiency presented three times to a medical facility over a period of 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically induced coma. Diagnostic workup including brain biopsy was unrevealing. Unbiased next-generation sequencing of the cerebrospinal fluid identified 475 of 3,063,784 sequence reads (0.016%) corresponding to leptospira infection. Clinical assays for leptospirosis were negative. Targeted antimicrobial agents were administered, and the patient was discharged home 32 days later with a status close to his premorbid condition. Polymerase-chain-reaction (PCR) and serologic testing at the Centers for Disease Control and Prevention (CDC) subsequently confirmed evidence of Leptospira santarosai infection.

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Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disease of unknown aetiology that usually occurs in the elderly. It is characterized by sterile pustules, chronic crusted erosions, cicatricial alopecia, and skin atrophy. The histopathology is nonspecific, and its pathophysiology remains undetermined, with various types of local trauma possibly acting as the triggering factor. We describe a case of EPDS in a 75-year-old female in whom there was a marked response to photodynamic therapy with methyl 5-aminolaevulinic acid.

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La hiperinsulina y la insulinorresistencia, tienen un papel importante en la fisiopatología de la hipertensión arterial esencial. Los efectos de la hiperinsulinemia son: aumento del tono simpático, estimulación del sistema Renina-Angiotensina'Aldosterona; disminución del factor, disminución del factor natriurético atrial y la retención de sodio tubular. En este trabajo se ha evaluado la acción de la dieta hiposódica en los pacientes hipertensos (PH), en un estudio prospectivo caso control doble ciego en una muestra de 59 pacientes, 35 mujeres y 24 varones, entre 30 y 60 años de edad; con diagnóstico de hipertensión arterial leve y moderada, sin tratamiento farmacológico previo; fueron sometidos a los siguientes estudios: dosaje de los niveles de insulina y glucosa en sangre a los 0,60 y 120 minutos luego de una carga oral de 75 grs. de glucosa, además de análisis de electrolitos y perfil lipídico (LDL, VLDL, HDL, triglicéridos). De acuerdo a los resultados de los niveles de insulinemia, los pacientes fueron divididos en 2 grupos principales: hipertensos hiperinsulinémicos (HTH) o Grupo I: 42 y pacientes hipertensos normoinsulinémicos (HTN) o Grupo II: 17. Estos 2 grupos fueron subdivididos para recibir dieta hiposódica (A), o dieta normosódica (B) aleatoriamente, así fueron conformados 4 subgrupos en total: Grupo IA: 22 pacientes; Grupo IB: 20 pacientes; y Grupo IIA: 10 pacientes, Grupo IIB: 7 pacientes. La dieta duró 4 semanas y los pacientes fueron evaluados en la semanaantes del inicio de la dieta y a las 1,2,3 y 4 semanas en los siguientes parámetros: adhesión a la dieta, índice de masa corporal (IMC) en Kg/m2, presión arterial sistólica (PAS), presión arterial diastólica (PAD) y presión arterial media (PAM) en mmHg...

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A quality conrol assesssment laboratories of clinical analysis was performed in March 1989. Glucose, urea, bilirubin, and GOT were determined in a sample of the same control serum. Statistical evaluation of the results showed that the coefficient of variation (CV) of each parameter was much higher than the internationally accepted values. A further evaluation included an internal precision control and an interlaboratory control. Urea, glucose and cholesterol were determined in twenty samples of the same serum lot per month by each laboratory. About 61 percent had an acceptable CV for glucose, 74.4 percent for urea and 65,6 percent for cholesterol

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