RESUMEN
A chemical study of the nonpolar fraction of a methanol-soluble extract of Bursera microphylla resin yielded a variety of di- and triterpenoids. In total, 15 compounds were isolated, of which three are new, namely, malabaricatrienone (1), malabaricatrienol (2), and microphyllanin (3). The antiproliferative activity of the major compounds was evaluated in different murine cancer cell lines (M12.C3.F6 and RAW264.7) and human cancer cells (A549, HeLa, and PC-3). The new compounds (1-3) did not show significant antiproliferative activity. The known compounds ariensin (4), burseran (5), and dihydroclusin diacetate (6) were effective against the RAW264.7 cell line, with IC50 values in the micromolar range.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Bursera/química , Diterpenos/aislamiento & purificación , Resinas de Plantas/química , Triterpenos/aislamiento & purificación , Animales , Antineoplásicos Fitogénicos/química , Diterpenos/química , Ensayos de Selección de Medicamentos Antitumorales , Furanos/farmacología , Células HeLa , Humanos , Lignanos/farmacología , México , Ratones , Estructura Molecular , Extractos Vegetales/química , Triterpenos/químicaRESUMEN
The in vitro anti-bacterial activity of auraptene and four prenyloxycinnamic and benzoic acids was evaluated against a panel of three bacterial strain. All compounds were shown to be active as inhibitory agents of the growth of Staphylococcus aureus.
La actividad antibacteriana in vitro del auraptene y de cuatro ácidos preniloxycinámicos y benzoicos ha sido evaluada sobre un grupo de tres distintas cepas bacterianas. Todos los compuestos mostraron ser activos como agentes inhibitorios del crecimiento del Staphylococcus Aureus.