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2.
Anim Reprod Sci ; 270: 107580, 2024 Aug 24.
Artículo en Inglés | MEDLINE | ID: mdl-39216207

RESUMEN

This study aimed to assess the impact of L-carnitine (LC) supplementation in conventional-slow (CS) and ultra-rapid (UR) freezing media on post-thaw quality and fertilizing ability of dog epididymal spermatozoa. Sperm samples were collected from 60 epididymides obtained from 30 adult orchiectomized dogs via retrograde flushing. Twenty pooled sperm samples were then created (3 epididymal samples/pool). Four treatments were established according to the freezing method (CS and UR) and LC supplementation (5 and 0 mM [control, Co]): CS-LC5, CS-Co, UR-LC5, and UR-Co. The CS freezing involved exposing 0.25 mL straw to liquid nitrogen vapors (LN2), while UR freezing submerged 30-µL drops of sperm samples directly into LN2. Sperm kinematics, membrane integrity, and fertilizing ability (by heterologous in vitro fertilization using bovine oocytes) were evaluated for all treatments. Post-thaw results revealed that the CS freezing treatments resulted in significantly higher values (P < 0.05) of curvilinear and average-path velocities, and beat-cross frequency compared to the UR freezing treatments, regardless of LC supplementation. The CS-LC5 and UR-LC5 treatments cryoprotected the sperm by increasing (P < 0.05) the percentage of 'live-sperm/intact-acrosome' compared to their controls treatments CS-Co and UR-Co. Regarding fertilizing ability, the CS-LC5 treatment yielded a higher percentage (P < 0.05) of pronuclei formation compared to both UR treatments. The UR-LC5 treatment, however, obtained greater percentage (P < 0.05) than their control UR-Co. In conclusion, supplementation with L-carnitine in conventional-slow and ultra-rapid freezing improved sperm motility, plasma, and acrosome membranes integrity and fertilizing ability of dog epididymal spermatozoa.

3.
J Dairy Sci ; 2024 Jul 12.
Artículo en Inglés | MEDLINE | ID: mdl-39004125

RESUMEN

The adulteration of milk presents significant challenges in the food industry, promoting the need for efficient detection methods. This study introduces a potentiometric electronic tongue for rapid and accurate milk adulteration detection. Utilizing polymeric membranes integrated with various additives, the electronic tongue distinguishes between different milk types and detects common adulterants. Experimental results demonstrate its effectiveness in discriminating raw, pasteurized, and medicated cow milk, as well as goat milk. Moreover, it successfully identifies adulterants like water and bovine milk in goat milk samples. Chemometric analyses, including Principal Component Analysis and Partial Least Squares regression, correlate sensor responses with traditional milk parameters such as fat, protein, and lactose content with up to a 0.97 R2 on the validation step. Strong correlations validate the electronic tongue's potential for rapid milk quality assessment. This innovative approach offers a cost-effective, reliable solution for detecting milk adulteration in contrast with current techniques that require numerous, time consuming experiments.

4.
Biol Lett ; 20(6): 20240082, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38889773

RESUMEN

Floral longevity, the length of time a flower remains open and functional, is a phylogenetically conserved trait that balances floral costs against the rate at which flowers are pollinated. Floral symmetry has long been considered a key trait in floral evolution. Although zygomorphic (bilaterally symmetric) flowers typically receive fewer floral visitors than actinomorphic (radially symmetric) flowers, it is yet to be determined whether this could be associated with longer floral longevity. Using newly collected field data combined with data from the literature on 1452 species in 168 families, we assess whether floral longevity covaries with floral symmetry in a phylogenetic framework. We find that zygomorphic flowers last on average 1.1 days longer than actinomorphic flowers, a 26.5% increase in longevity, with considerable variation across both groups. Our results provide a basis to discuss the ecological and evolutionary costs of zygomorphy for plants. Despite these costs, zygomorphy has evolved numerous times throughout angiosperm history, and we discuss which rewards may outweigh the costs of slower pollination in zygomorphic flowers.


Asunto(s)
Evolución Biológica , Flores , Magnoliopsida , Filogenia , Polinización , Flores/anatomía & histología , Flores/fisiología , Magnoliopsida/fisiología , Magnoliopsida/anatomía & histología
5.
Rev Clin Esp (Barc) ; 224(7): 421-427, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38871291

RESUMEN

AIM: This work aims to evaluate whether electronic consultations (e-consults) are a clinically useful, safe tool for assessing patients between primary care and internal medicine. METHODS: This is a retrospective cohort study of all e-consults ordered by the Primary Care Department to the Internal Medicine Department between September 2019 and December 2023. The results of initial consultations, emergency department visits and subsequent admissions, and survival were assessed and complaints and claims filed were reviewed. RESULTS: A total of 11,434 e-consults were recorded (55.4% women) with a mean age of 62.1 (SD19.4) years and a wide range (15-102 years). The mean response time was 2.55 (SD 1.6) days. As a result of the e-consults, 5645 patients (49.4%) were given an in-person appointment. For the remaining 5789 (50.6%), a written response was provided. Among those given appointments, the time between the response and in-person appointment was less than five days (95% of cases). Compared to those not given appointments, in-person appointments were older (p < 0.0001), visited the emergency department more times (one month: p = 0.04; three months: p = 0.001), were admitted to the hospital more times (one month: p = 0.0001; three months: p = 0.0001), and had higher mortality at one year (12.7% vs. 9.8% p = 0.0001). In the Cox analysis, only in-person appointments (RR = 1.11; p = 0.04)) and age (RR = 1.09; p < 0.01) were independent factors of mortality. No complaints or claims of any kind were registered. CONCLUSIONS: These data suggest that e-consults are a clinically useful, safe tool for assessing patients referred from primary care to internal medicine departments.


Asunto(s)
Medicina Interna , Atención Primaria de Salud , Humanos , Femenino , Atención Primaria de Salud/estadística & datos numéricos , Persona de Mediana Edad , Masculino , Estudios Retrospectivos , Anciano , Adulto , Anciano de 80 o más Años , Adolescente , Adulto Joven , Servicio de Urgencia en Hospital/estadística & datos numéricos , Consulta Remota/estadística & datos numéricos , Accesibilidad a los Servicios de Salud
6.
Clín. investig. ginecol. obstet. (Ed. impr.) ; 51(2): [100948], Abri-Jun, 2024. ilus
Artículo en Español | IBECS | ID: ibc-232736

RESUMEN

La criobiología se enfoca en entender cómo reaccionan los materiales biológicos a temperaturas muy bajas. Este campo ha experimentado avances significativos, particularmente en el ámbito de la reproducción asistida, donde se han desarrollado programas para preservar la fertilidad. Estos desarrollos revisten importancia crítica para quienes exploran alternativas en materia de fertilidad y preservación de gametos. Por otro lado, la preservación de la fertilidad tiene como objetivo proteger la capacidad reproductiva de una persona por diferentes condiciones de salud, tratamientos médicos o razones sociales que la puedan comprometer. Las técnicas aceptadas para la preservación de fertilidad en humanos son la criopreservación de gametos y de embriones. Existe evidencia prometedora creciente sobre distintas técnicas experimentales dentro de este campo, como la crioconservación del tejido gonadal, o estrategias de maduración in vitro, así como nuevas metodologías en los protocolos criogénicos que supondrán una optimización de los resultados y un punto de inflexión dentro del campo de la reproducción asistida. Este trabajo tiene como objetivo explorar el estado del arte de las estrategias actuales ofrecidas a las mujeres en el contexto de preservación de la fertilidad, revisar los avances en criobiología y su papel en la evolución de este ámbito.(AU)


Cryobiology focuses on understanding how biological materials react to very low temperatures. This field has experienced significant advances, particularly in the field of assisted reproduction, where programs have been developed to preserve fertility. These developments are of critical importance for those exploring alternatives in fertility and gamete preservation. Fertility preservation aims to protect a person's reproductive capacity under various health conditions, medical treatments, and social reasons that may compromise it. Accepted techniques for human fertility preservation include the cryopreservation of gametes and embryos. There is growing promising evidence on different experimental techniques within this field, such as cryopreservation of gonadal tissue or in vitro maturation strategies, as well as new methodologies in cryogenic protocols that will optimize results and mark a turning point in the field of assisted reproduction. This work aims to explore the current state-of-the-art strategies offered to women in the context of fertility preservation, review advances in cryobiology, and its role in the evolution of this area.(AU)


Asunto(s)
Humanos , Femenino , Preservación de la Fertilidad , Criobiología , Ovario/fisiología , Vitrificación
7.
Clín. investig. ginecol. obstet. (Ed. impr.) ; 51(2): [100950], Abri-Jun, 2024. tab
Artículo en Español | IBECS | ID: ibc-232738

RESUMEN

La terapia hormonal de afirmación de género con testosterona (GAHT, por sus siglas en inglés) permite, a las personas transgénero del espectro masculino, modificar las características sexuales secundarias del sexo asignado al nacer, aliviando así los síntomas de la disforia de género durante el proceso denominado transición. Sin embargo, se debe tener presente que se desconoce, en la actualidad, el efecto de la GAHT sobre la fertilidad a largo plazo, y el potencial efecto gonadotóxico de la misma. La demanda de un correcto asesoramiento reproductivo y la opción de realizar técnicas de preservación de la fertilidad (PF) han aumentado de forma exponencial en los últimos años, comportando cambios profundos en el manejo clínico de estas personas. En este artículo se realiza una revisión bibliográfica sobre el efecto de la GAHT a nivel reproductivo y en la fertilidad, junto con las técnicas de PF disponibles en este colectivo, principalmente la vitrificación de ovocitos. Además, realizamos un análisis de los resultados reproductivos publicados hasta la fecha tras el uso de técnicas de preservación, y exponemos los últimos avances de laboratorio en relación con la criopreservación de tejido ovárico y la maduración in vitro de ovocitos, junto con las opciones de futuro en población transgénero del espectro masculino.(AU)


Gender affirming hormone therapy (GAHT) in transmasculine people (individuals who identify as men or on the masculine spectrum and were assigned female sex at birth) makes it possible to modify the secondary sexual characteristics of the sex assigned at birth, thus alleviating the symptoms of gender dysphoria, during the process called transition. However, it is necessary to highlight that the effect of GAHT on long-term fertility and its potential gonadotoxic effects are currently unknown. Knowledge of the effects of testosterone on fertility and reproduction has increased recently, whilst the request for comprehensive reproductive counselling and the option of performing fertility preservation (FP) techniques have increased exponentially in recent years, leading to profound changes in the clinical management of this population. In this review, we analyzed all the information published regarding the effect of GAHT on reproduction and the FP techniques available in this group, mainly oocyte vitrification. In addition, we carry out an exhaustive analysis of the reproductive results published to date after the use of preservation techniques and present the latest laboratory advances concerning ovarian tissue cryopreservation and in vitro oocyte maturation, together with future options in the transmasculine people.(AU)


Asunto(s)
Humanos , Femenino , Preservación de la Fertilidad , Personas Transgénero , Terapia de Reemplazo de Hormonas , Vitrificación , Técnicas de Maduración In Vitro de los Oocitos
8.
Rev Clin Esp (Barc) ; 224(5): 288-299, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38614320

RESUMEN

In recent years, the interest in cardiac amyloidosis has grown exponentially. However, there is a need to improve our understanding of amyloidosis in order to optimise early detection systems. Therefore, it is crucial to incorporate solutions to improve the suspicion, diagnosis and follow-up of cardiac amyloidosis. In this sense, we designed a tool following the different phases to reach the diagnosis of cardiac amyloidosis, as well as an optimal follow-up: a) clinical suspicion, where the importance of the "red flags" to suspect it and activate the diagnostic process is highlighted; 2) diagnosis, where the diagnostic algorithm is mainly outlined; and 3) follow-up of confirmed patients. This is a practical resource that will be of great use to all professionals caring for patients with suspected or confirmed cardiac amyloidosis, to improve its early detection, as well as to optimise its accurate diagnosis and optimal follow-up.


Asunto(s)
Amiloidosis , Cardiomiopatías , Humanos , Amiloidosis/diagnóstico , Amiloidosis/terapia , Cardiomiopatías/diagnóstico , Cardiomiopatías/terapia , Algoritmos , Cardiopatías/diagnóstico , Cardiopatías/terapia
10.
Neurosci Biobehav Rev ; 159: 105572, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38320657

RESUMEN

BACKGROUND: Internet Addiction (IA) refers to excessive or uncontrolled behaviors related to Internet access, causing impairment or distress. Similarly, Smartphone Addiction (SPA) involves the excessive use of smartphones, disrupting users' daily lives. Cognitive control plays a relevant role in the development of IA and SPA, with executive functions and rewards processing being particularly important. OBJECTIVE: This study aims to provide a synthesis of scientific evidence on the differential effects of IA and SPA on cognition in young adults and adolescents, using fMRI. METHODS: Relevant articles published between 2013 and May 2023 were identified following the PRISMA protocol. RESULTS: Included studies (n = 21) revealed that both behavioral addictions were associated with impairments in cognitive control related to reward processing (ACC, insula, amygdala) and executive function (DLPFC, frontal, parietal lobes) in adolescents and young adults. CONCLUSION: These findings provide evidence for neuroanatomical similarities between IA and SPA in young adults and adolescents related to executive functions and rewards processing. However, differential effects of SPA and IA on cognitive control were not found in this study. Future research should explore the relationship between these addictions with other cognitive domains to further expand our understanding within this field. While both IA and SPA involve the excessive use of online technology, SPA could involve a higher risk, given that smartphones allow internet connectivity anytime.


Asunto(s)
Función Ejecutiva , Trastorno de Adicción a Internet , Imagen por Resonancia Magnética , Teléfono Inteligente , Humanos , Adolescente , Trastorno de Adicción a Internet/fisiopatología , Trastorno de Adicción a Internet/diagnóstico por imagen , Adulto Joven , Función Ejecutiva/fisiología , Conducta Adictiva/fisiopatología , Conducta Adictiva/diagnóstico por imagen , Encéfalo/fisiopatología , Encéfalo/diagnóstico por imagen , Recompensa , Cognición/fisiología , Internet
11.
New Microbes New Infect ; 56: 101200, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-38162836

RESUMEN

Non-O1, non-O139 Vibrio cholerae (NOVC) is an emergent pathogen that mainly causes gastroenteritis. Also, it causes ear, wound infections, and bacteremia but the nervous system is rarely affected. We report on a case of NOVC meningoencephalitis in an infant that recovered after antimicrobial therapy but later presented neurologic sequelae.

12.
Acta Trop ; 248: 107014, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37696485

RESUMEN

Could tropical forest conversion shape sand fly (Diptera: Phlebotominae) biting rhythms and Leishmania infection rates? Using a Shannon trap, we estimated the bite rate and infection prevalence among anthropophilic sand flies at sites with different land use in southern Mexico. We estimated the expected monthly infection rate of the Leishmania parasite along the gradient and generated information on the biting rhythm of sand flies in a poorly characterized cutaneous leishmaniasis endemic region. We used generalized mixed linear and mixed additives models to evaluate differences in the biting rate, nocturnal activity, and inoculation rate of female sand flies, as well as their relationship with the loss of forest cover and environmental disparities recorded throughout the study area. Our results show that the loss of forest cover influences the biting rhythm of sand fly species and the potential number of infectious bites with Leishmania, but the greatest entomological and potential epidemiological risk continues to be associated with sylvatic areas (amplification events). Despite this, we detected that the effect of forest cover (%) on the entomological exposure seems to be also dependent on the sand fly species, and that, albeit to a lesser extent, Leishmania parasite is circulating in disturbed landscapes through generalist and competent sand fly vector species. We also found that land use change did not affect the nocturnal activity, however we detected that important vector species were active most of the time. Contrary to our expectation, temperature and humidity did not shape the biting rhythm of sand fly species. We discuss the limitations and epidemiological implications of our findings regarding the risk of contracting leishmaniasis in southern Mexico.


Asunto(s)
Mordeduras y Picaduras , Leishmania , Leishmaniasis Cutánea , Phlebotomus , Psychodidae , Animales , Femenino , Psychodidae/parasitología , México/epidemiología , Insectos Vectores/parasitología , Leishmaniasis Cutánea/epidemiología
14.
Front Robot AI ; 10: 1127496, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37064576

RESUMEN

Space resource utilisation is opening a new space era. The scientific proof of the presence of water ice on the south pole of the Moon, the recent advances in oxygen extraction from lunar regolith, and its use as a material to build shelters are positioning the Moon, again, at the centre of important space programs. These worldwide programs, led by ARTEMIS, expect robotics to be the disrupting technology enabling humankind's next giant leap. However, Moon robots require a high level of autonomy to perform lunar exploration tasks more efficiently without being constantly controlled from Earth. Furthermore, having more than one robotic system will increase the resilience and robustness of the global system, improving its success rate, as well as providing additional redundancy. This paper introduces the Resilient Exploration and Lunar Mapping System, developed with a scalable architecture for semi-autonomous lunar mapping. It leverages Visual Simultaneous Localization and Mapping techniques on multiple rovers to map large lunar environments. Several resilience mechanisms are implemented, such as two-agent redundancy, delay invariant communications, a multi-master architecture different control modes. This study presents the experimental results of REALMS with two robots and its potential to be scaled to a larger number of robots, increasing the map coverage and system redundancy. The system's performance is verified and validated in a lunar analogue facility, and a larger lunar environment during the European Space Agency (ESA)-European Space Resources Innovation Centre Space Resources Challenge. The results of the different experiments show the efficiency of REALMS and the benefits of using semi-autonomous systems.

16.
BMC Cardiovasc Disord ; 23(1): 13, 2023 01 12.
Artículo en Inglés | MEDLINE | ID: mdl-36635626

RESUMEN

BACKGROUND: Right ventricular (RV) dysfunction in patients with non-ischemic dilated cardiomyopathy (NICM) is associated with cardiovascular events. To analyze the feasibility of assessing RV myocardial deformation by feature tracking (FT)-cardiac magnetic resonance (CMR), and its usefulness as a prognostic marker. METHODS: Retrospective study of NICM patients undergoing CMR. Longitudinal FT-RV free wall (LFT-RVFW) and fractional area change (FAC) were obtained. Correlation with standard RV parameters was studied. An association with combined event (heart failure (HF), ICD implantation or cardiovascular death) was assessed using a logistic regression model. RESULTS: 98 patients (64 ± 13 years) were included. Left ventricular (LV) systolic function (LVEF 29.5 ± 9.6%, 47% with LVEF ≥ 30%) and RV (RVEF 52.2 ± 14.6%, 72% with RVEF ≥ 45%). Follow-up of 38 ± 17 months, 26.5% presented at least one admission for HF. An excellent correlation of LFT-RVFW (r = 0.82) and FAC (r = 0.83) with RVEF was evident. No association of RV-FT parameters with prognosis entire study population was found. However, in patients with LVEF ≥ 30%, admissions for HF were associated with lower LFT-RVFW (-21.6 ± 6.6% vs -31.3 ± 10%; p = 0.006) and FAC (36.6 ± 9.6% vs 50.5 ± 13.4%; p < 0.001) values. Similar differences were observed when only patients with RVEF ≥ 45% were considered. An LFT-RVFW cut-off point of -19.5% and FAC of 36.5% showed good prognostic performance. Decreased LFT-RVFW or FAC represented an independent predictor of combined event in patients with LVEF ≥ 30%. CONCLUSIONS: In NICM patients without severe LV dysfunction, decreased values of LFT-RVFW and/or FAC were associated with HF admissions, independently of RVEF.


Asunto(s)
Cardiomiopatía Dilatada , Insuficiencia Cardíaca , Disfunción Ventricular Derecha , Humanos , Estudios Retrospectivos , Imagen por Resonancia Cinemagnética , Disfunción Ventricular Derecha/diagnóstico por imagen , Disfunción Ventricular Derecha/etiología , Cardiomiopatía Dilatada/diagnóstico por imagen , Espectroscopía de Resonancia Magnética , Función Ventricular Derecha , Volumen Sistólico
17.
Scand J Rheumatol ; 52(3): 268-275, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-35343366

RESUMEN

OBJECTIVE: To investigate the relationship between pain extent, as a clinical sign of central sensitization, and clinical, psychological, and pressure sensitivity in women with fibromyalgia syndrome (FMS). METHOD: In this study, 126 females with FMS completed demographic (age, gender, body mass index, height, weight), clinical (pain history, and pain intensity at rest and during daily living activities), psychological (depression and anxiety levels), and neurophysiological [pressure pain threshold (PPT)] assessments. The Central Sensitization Inventory (CSI) was also used to collect self-reported symptoms of sensitization. Pain extent and frequency maps were obtained from pain drawings using customized software. After conducting a multivariable correlation analysis to determine the relationships between variables, a stepwise linear regression model analysis was performed to identify variables associated with pain extent. RESULTS: Pain extent was positively associated with age (r = 0.17), years with pain (r = 0.27), pain during daily life activities (r = 0.27), and CSI (r = 0.42) (all p < 0.05). The stepwise regression analysis revealed that 27.8% of the pain extent was explained by CSI, age, and years with pain. CONCLUSIONS: This study found that larger pain extent was associated with self-reported outcomes, i.e. CSI, but not neurophysiological outcomes, i.e. PPTs, of sensitization in women with FMS. Older age and a longer history with pain symptoms were also associated with larger pain extent.


Asunto(s)
Fibromialgia , Humanos , Femenino , Fibromialgia/diagnóstico , Fibromialgia/psicología , Umbral del Dolor/fisiología , Sensibilización del Sistema Nervioso Central , Dimensión del Dolor , Autoinforme
18.
Eur Rev Med Pharmacol Sci ; 26(18): 6700-6724, 2022 09.
Artículo en Inglés | MEDLINE | ID: mdl-36196720

RESUMEN

EMMPRIN, also known as Basigin or CD147, is a transmembrane glycoprotein member of the immunoglobulin superfamily. It is expressed basally in cells that regulate physiological processes of the cardiovascular, nervous, and immune systems. However, EMMPRIN is also capable of interacting with different proteins, like VEGFR, SMAD4, Integrin, MCT, CyPA, GLUT1, CAIV, Annexin II, Cav-1, CAML, etc., and regulating signaling pathways that stimulate the cell processes of proliferation, apoptosis, metabolism, adhesion, invasion, migration, metastasis, tumor immune response, and angiogenesis processes, which favors the development of different types of cancer. EMMPRIN is the first protein reported that favors cancer development due to its ability to interact with extracellular, intracellular, and membrane proteins. In conclusion, EMMPRIN regulates several proteins associated with the development of tumor processes. Therefore, blocking the expression of EMMPRIN can be a therapeutic target, and the analysis of its expression can be used as an important biomarker in cancer.


Asunto(s)
Basigina , Neoplasias , Anexina A2 , Basigina/metabolismo , Transportador de Glucosa de Tipo 1 , Humanos , Integrinas/metabolismo , Proteínas de la Membrana/metabolismo , Neoplasias/patología
19.
J Helminthol ; 96: e77, 2022 Oct 21.
Artículo en Inglés | MEDLINE | ID: mdl-36268741

RESUMEN

In order to identify types of forage that inhibit pasture contamination, an evaluation was performed of the effect of the forage legumes Trifolium repens (white clover), Trifolium pratense (red clover) and Lotus corniculatus (bird's-foot-trefoil) on the survival and migration of infective larvae (L3) of gastrointestinal nematodes (GIN) of sheep. An experimental area of 441 m2 was divided into four blocks, subdivided into areas of 1.20 × 1.20 in which the three forage legumes were separately overseeded. After growth of the forage in each subdivision, experimental units were established that were later artificially contaminated with sheep faeces containing GIN eggs. Between October and December 2018, pasture, faecal and soil samples were collected on four occasions during weeks 1, 2, 4 and 8 after the deposition of faeces. In week 6, the forage legumes in all the experimental units were mown to simulate grazing. The number of L3 was quantified to determine their survival in the pasture, faeces and soil. In addition, the horizontal migration of L3 was measured at two distances from the faecal pellets (10 and 30 cm), as well as their vertical migration at two heights of the plant stems, that is, lower half and upper half. Larvae vertical migration was affected by the forage species (P < 0.001), in that bird's-foot-trefoil contained fewer larvae in the upper stratum. Bird's-foot-trefoil restricted the migration of L3 to the upper stratum of the plant, which could potentially decrease the risk of infection by intestinal nematodes in grazing sheep.


Asunto(s)
Fabaceae , Helmintos , Nematodos , Enfermedades de las Ovejas , Ovinos , Animales , Heces , Larva , Verduras , Suelo
20.
Arch. Soc. Esp. Oftalmol ; 97(10): 543-548, Oct. 2022.
Artículo en Español | IBECS | ID: ibc-209648

RESUMEN

Objetivo general Evaluar la precisión y validez de imágenes vía teléfono inteligente en comparación con el sistema RetCam® para el diagnóstico de retinopatía del prematuro (ROP). Metodología Estudio observacional, de corte longitudinal y enmascarado realizado en el hospital Dr. Elías Santana. Se incluyeron infantes con peso al nacer ≤ 1.500 g, edad gestacional ≤ 30 semanas y/o pacientes expuestos a factores de riesgo o complicaciones ligadas a ROP. Estos sujetos fueron tamizados empleando imágenes vía teléfono inteligente o RetCam®, ambos comparados con la fondoscopía convencional. Se utilizó la clasificación de ICROP para la estadificación. Los resultados principales analizados fueron sensibilidad, especificidad, valores predictivos e índice kappa. Resultados Se obtuvieron 915 imágenes (n = 121), distribuidas en grupo teléfono inteligente (50,4%) y grupo RetCam® (49,6%) entre agosto del 2020 y marzo del 2021. Los sujetos que presentaron ROP tuvieron menor edad gestacional (30,2 sem ± 2.8), peso al nacer (1.361 g ± 398) y mayor exposición a oxigenoterapia (12,8 días ± 11,3). El grupo RetCam® presentó sensibilidad = 80%, especificidad = 78%, valor predictivo positivo = 90% e índice kappa = 0,70. El grupo teléfono inteligente presentó sensibilidad = 88%, especificidad = 90%, valor predictivo positivo = 93,75% e índice kappa = 0,81. Conclusiones Ambos métodos diagnósticos fueron precisos para identificar ROP. El grupo teléfono inteligente obtuvo resultados superiores con una excelente resolución, representando un método costo-efectivo para crear un impacto global en la reducción de la ceguera prevenible en población pediátrica (AU)


General objective To evaluate the accuracy and validity of images with smartphone compared to the RetCam® system for the diagnosis of retinopathy of prematurity (ROP). Methodology Observational, longitudinal and masked study carried out at the Dr. Elías Santana hospital. Infants with birth weight ≤ 1500 g, gestational age ≤ 30 weeks and/or patients exposed to risk factors or complications linked to ROP were included. These subjects were screened using images with smartphone or RetCam®, both compared to conventional fundoscopy. The ICROP classification was used for staging. The main results analyzed were sensitivity, specificity, positive predictive values and kappa index. Results 915 images (n = 121) were obtained, distributed in smartphone group (50.4%) and RetCam® group (49.6%) between August 2020 and March 2021. Subjects with ROP had lower gestational age (30.2 sem ± 2.8), birth weight (1361 g ± 398), and greater exposure to oxygen therapy (12.8 days ± 11.3). The RetCam® group presented sensitivity = 80%, specificity = 78%, positive predictive value = 90% and kappa index = 0.70. The smartphone group presented sensitivity = 88%, specificity = 90%, positive predictive value = 93.75% and kappa index = 0.81. Conclusions Both diagnostic methods were accurate to identify ROP. The smartphone group obtained superior results with excellent resolution, representing a cost-effective method to create a global impact on reducing preventable blindness in the pediatric population (AU)


Asunto(s)
Humanos , Recién Nacido , Retinopatía de la Prematuridad/diagnóstico por imagen , Telemedicina/métodos , Recien Nacido Prematuro , Estudios Longitudinales , Edad Gestacional , Peso al Nacer , Tamizaje Neonatal , Reproducibilidad de los Resultados
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