RESUMEN
BACKGROUND: The severe neurologic tumor known as glioblastoma (GBM), also referred to as a grade IV astrocytoma, is rapidly progressive and debilitating. Supratotal resection (SpTR) is an emerging concept within glioma surgery, which aims to achieve a more extensive resection of the tumor than is possible with conventional techniques. METHODS: We performed a language-independent search of PubMed, Scopus, and Cochrane CENTRAL to identify all available literature up to August 2022 of patients undergoing SpTR assessing survival outcomes in comparison to other surgical modalities. RESULTS: After screening for exclusion, a total of 13 studies, all retrospective in design, were identified and included in our meta-analysis. SpTR was associated with significantly increased overall survival (hazard ratio 0.77, 95% CI 0.71-0.84; P < 0.01, I2 = 96%) and progression-free survival (hazard ratio 0.2, 95% CI 0.07-0.56; P = 0.002, I2 = 88%). CONCLUSION: SpTR is associated with greater overall survival and PFS when compared with other glioblastoma surgeries like GTR or SubTR.
Asunto(s)
Astrocitoma , Neoplasias Encefálicas , Glioblastoma , Glioma , Humanos , Glioblastoma/cirugía , Estudios Retrospectivos , Neoplasias Encefálicas/cirugía , Astrocitoma/cirugía , Glioma/cirugía , Procedimientos Neuroquirúrgicos/métodosRESUMEN
OBJECTIVE: To investigate the prevalence of malnutrition in children aged <5 years, and find out the risk factors associated with malnutrition in a rural setting. METHODS: The survey-based cross-sectional study was conducted from October 2017 to March 2018 in four Tehsils of district Tharparkar, Sindh, Pakistan, and comprised children of either gender aged <5 years who were randomly selected and assessed for weight and height using the World Health Organisation Anthro-2007 tool to obtain Z-score. Data was analysed using SPPS Version 18. RESULTS: Of the 597 subjects, 299(50.1%) were girls and 298(49.9%) were boys. Overall, 219(36.7%) were aged 12-23 months and 63(10.5%) were aged 48-59 months. Stunting was found in 485(81.1%) subjects, wasting 112(18.2%) and 342(57.3%) were underweight. The causes of malnutrition included age 6-11 months, number of siblings, monthly income <6000 rupees and duration of breast feeding <12 months (p<0.05). CONCLUSIONS: Higher prevalence of malnutrition was found in children aged <5 years in district Tharparkar.