RESUMEN
The authors have repeatedly examined the functional capacity of suprarenal cortex in patients on long-term dialysis by means of ACTH stimulation test. Out of 148 examinations, normal reaction was found in 111 cases, partially insufficient in 16 cases, and fully insufficient in 21 cases. Primary suprarenal insufficiency is considered for the reason of insufficient production of cortisol which develops due to enforced changes of regulatory mechanism in glucocorticoids production as a reaction on repeated long-term losses of cortisol through semipermeable membrane. According to the authors, the mentioned facts are of great significance since they may result in changes which influence the survival of patients on long-term dialysis in a negative way.
Asunto(s)
Corteza Suprarrenal/fisiopatología , Fallo Renal Crónico/terapia , Diálisis Renal , 11-Hidroxicorticoesteroides/sangre , Pruebas de Función de la Corteza Suprarrenal , Hormona Adrenocorticotrópica , Femenino , Humanos , Fallo Renal Crónico/sangre , Fallo Renal Crónico/fisiopatología , MasculinoAsunto(s)
Lesión Renal Aguda/terapia , Diálisis Renal/métodos , Adolescente , Adulto , Checoslovaquia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Estudios RetrospectivosAsunto(s)
Lesión Renal Aguda/diagnóstico por imagen , Angiografía/métodos , Fallo Renal Crónico/diagnóstico por imagen , Ultrasonografía , Lesión Renal Aguda/diagnóstico , Lesión Renal Aguda/patología , Biopsia/métodos , Humanos , Fallo Renal Crónico/diagnóstico , Fallo Renal Crónico/patología , Magnificación Radiográfica/métodosRESUMEN
Authors studied serotonin (5-hydroxytryptamin) in blood in patients with severe renal failure. Changes of serotonin in platelets and plasma in renal failure possibly play a part in clotting disorders of uremia. The authors found increased levels of serotonin in the patients, who suffered from acute and chronic renal failure. 15 patients were dialysed in regular dialysis treatment. Serotonin increased in blood after each dialysis. Platelets remained unchanged during hemodialysis. The authors discuss these new findings and correlate the above mentioned changes with electrolytes and some other laboratory findings.