RESUMEN
The publication presents investigation evaluated of separate and combined effects of calcium pantothenate deficiency and cadmium (Cd2+) intoxication on rat reproductive function. The experi-ments were performed on 280 adult and 890 offspring of Wistar rats. Reproductive function was estimated by fertility study, prenatal and postnatal development of offspring. The separate and combined effects of and cadmium intoxication during the mating period and pregnancy had no effect on fertility and fecundity of rats, pre-and postimplantation loss, the survival of offspring, and not caused the abnormal development of skeleton and internal organs. However, in prenatal ontogeny of this effect was manifested by lower body weight and fetal growth, postnatal - underdevelopment of rat pups in all morphological and functional studied parameters and increasing number of stillbirths in the offspring.
Asunto(s)
Cadmio/toxicidad , Ácido Pantoténico/deficiencia , Preñez , Reproducción/efectos de los fármacos , Animales , Animales Recién Nacidos , Conducta Animal/efectos de los fármacos , Peso Corporal/efectos de los fármacos , Cadmio/administración & dosificación , Embrión de Mamíferos/efectos de los fármacos , Desarrollo Embrionario/efectos de los fármacos , Femenino , Fertilidad/efectos de los fármacos , Masculino , Exposición Materna , Fenómenos Fisiológicos de la Nutrición , Ácido Pantoténico/farmacología , Exposición Paterna , Embarazo , Efectos Tardíos de la Exposición Prenatal , Ratas , Ratas Wistar , Factores de Tiempo , Complejo Vitamínico B/farmacologíaRESUMEN
There are presented the results of a comparative assessment of the semi-synthetic casein diet, traditionally used by Institute of Nutrition RAMS, and the AIN-93 purified diet, offered by the American Institute of Nutrition, on growth and development of rats. A total of 60 male Wistar rats were used at 90-days experiment, rats were divided into two groups: first group received the semi-synthetic casein diet, the second group--AIN-93 diet. Analysis of integral, hematological and biochemical parameters revealed some differences between groups, but values of all studied parameters were within the physiological norm for Wistar rat. Based on the results of this experiment were suggested a new formulation of a diet for laboratory animals.
Asunto(s)
Envejecimiento , Alimentación Animal , Fenómenos Fisiológicos Nutricionales de los Animales , Dieta/normas , Necesidades Nutricionales , Envejecimiento/sangre , Envejecimiento/metabolismo , Animales , Peso Corporal , Masculino , Tamaño de los Órganos , Ratas , Ratas WistarRESUMEN
It has been shown that biotopes of upper respiratory system and intestine were contaminated with yeast in 44.6% of patients with leukaemia (of 112 examined ones). Their quantity exceeds the boundary value for practically healthy people and is > or = 10(2) KOE/ml in the nasal activity and fauces and < or = 10(4) KOE/g in the intestine. It was established that in patients with leucemia the mycotic complications are mainly caused by anamorphous yeast of ascomycetic affinity. Candida albicans, as well as C. glabrata, C. rugosa and Candida sp. play the leading role. The Candida genus species are mainly sensitive to amphotericine B, clotrisamol and nistatin.
Asunto(s)
Intestinos/microbiología , Leucemia/microbiología , Micosis/prevención & control , Infecciones Oportunistas/prevención & control , Sistema Respiratorio/microbiología , Levaduras/aislamiento & purificación , Adulto , Anciano , Antifúngicos/farmacología , Humanos , Leucemia/complicaciones , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Micosis/complicaciones , Micosis/microbiología , Infecciones Oportunistas/complicaciones , Infecciones Oportunistas/microbiología , Levaduras/efectos de los fármacos , Adulto JovenRESUMEN
This review paper describes the evolution of the ideas of periodontal tissue regeneration, starting with the concept of selective cellular repopulation, stimulation of resident precursor cells in the regeneration focus, up to the application of versatile potential of the stromal stem cells (SSC). Effects of stem cells isolated from an embryo, bone marrow, and adipose tissue, are described, as well as the immunophenotype of freshly isolated SSC, that of precultured vascular cell fraction as compared with the immunophenotype of SSC cultured during various time periods. The results of the study of the processes of proliferation and cell differentiation of SSC transplanted into the deep periodontal defects, are analyzed using proliferating cell nuclear antigen (PCNA) and green fluorescent protein. During the process of regeneration, the interaction of transplanted SSC with the local microenvironment is mediated by special membranous cell receptors. The coordination of cell behavior by means of adhesive and communicative contacts which provide a signal platform for the control of cellular functions, is discussed.
Asunto(s)
Pérdida de Hueso Alveolar/cirugía , Regeneración Ósea/fisiología , Trasplante de Células Madre , Células del Estroma/trasplante , Pérdida de Hueso Alveolar/patología , Animales , Diferenciación Celular/fisiología , HumanosRESUMEN
A new donor antidiphtheritic immunoglobulin produced in the Hematology and Transfusiology Institute of AMS of Ukraine and Donetsk transfusiology station is discussed in the article. The medication, antidiphtheritic horse serum had been used during the diphtheria epidemic, as a medication in Donetsk clinics. The medication meets requirements of State and International Standards and is registered in Ukraine.
Asunto(s)
Antitoxina Diftérica/uso terapéutico , Difteria/tratamiento farmacológico , Sueros Inmunes/inmunología , Inmunoglobulinas/uso terapéutico , Animales , Donantes de Sangre , Difteria/inmunología , Antitoxina Diftérica/administración & dosificación , Caballos , Humanos , Sueros Inmunes/administración & dosificación , Inmunoglobulinas/administración & dosificación , Inyecciones Intramusculares , UcraniaAsunto(s)
Difteria/prevención & control , Adolescente , Niño , Preescolar , Difteria/epidemiología , Difteria/inmunología , Difteria/terapia , Antitoxina Diftérica/uso terapéutico , Vacuna contra Difteria, Tétanos y Tos Ferina/inmunología , Brotes de Enfermedades/prevención & control , Humanos , InmunizaciónAsunto(s)
Malformaciones Arteriovenosas/diagnóstico , Enfermedades Intestinales/diagnóstico , Intestino Grueso/irrigación sanguínea , Adolescente , Malformaciones Arteriovenosas/complicaciones , Malformaciones Arteriovenosas/cirugía , Niño , Preescolar , Diagnóstico Diferencial , Femenino , Hemorragia Gastrointestinal/congénito , Hemorragia Gastrointestinal/diagnóstico , Hemorragia Gastrointestinal/etiología , Hemorragia Gastrointestinal/cirugía , Humanos , Lactante , Enfermedades Intestinales/complicaciones , Enfermedades Intestinales/congénito , Enfermedades Intestinales/cirugía , Intestino Grueso/cirugía , Masculino , RecurrenciaRESUMEN
Antiproteic donor plasma was included into the complex of treatment of 54 severely burned children, who had their clinical state, immunologic and hematologic indices been studied. A pronounced therapeutic effect of antiproteic immunotherapy was noted.
Asunto(s)
Quemaduras/terapia , Inmunoterapia/métodos , Plasma/inmunología , Proteínas/inmunología , Quemaduras/inmunología , Niño , HumanosRESUMEN
The authors describe a patient with abnormal development of the cervical vertebrae and the formation of a block typical of the Klippel-Weil syndrome, as well as craniovertebral synostosis with the complete absence of the atlantooccipital joint, a bizarre and complicated course of the canals of vertebral arteries and sublingual nerves. They also outline the mechanisms of the possible development in such conditions of neurological symptomatology and disorders of cerebral, spinal and radiculo-neural blood circulation.