RESUMEN

Human and animal blood plasm precallikrein was studied as activated by the high-dispersed preparations of silica (aerosils) which carry on their surface various chemically grafted organic radicals. It is shown that hydrophilic silica containing -COOH, -HN2, -OH groups, contrary to the hydrophobic ones, are efficient in activating human plasm precallikrein. Precallikrein activation is dependent on concentration of hydrophilic aerosil, temperature and specific surface of the activator.

Asunto(s)

Calicreínas/fisiología , Precalicreína/fisiología , Dióxido de Silicio/farmacología , Aerosoles , Animales , Fenómenos Químicos , Química Física , Relación Dosis-Respuesta a Droga , Activación Enzimática/efectos de los fármacos , Humanos , Técnicas In Vitro , Tamaño de la Partícula , Propiedades de Superficie , Temperatura