RESUMEN
OBJECTIVE: The aim of this article is to compare the diagnosis, obtained through different methods and indicators, of nutritional risk in patients with cancer. METHODS: It was assessed nutritional risk in of 144 oncology patients was assessed, making use of Subjective Global Assessment (SGA, Detsky 1987), Malnutrition Universal Screening Tool (MUST, 2003), Body Mass Index (BMI) and Serum Albumin. STATISTICAL ANALYSIS: Kappa, chi-square and McNemar tests. RESULTS: It was found a high prevalence of malnutrition (MUST, 78.32%; SGA, 77.08%; serum albumin level< 3.5 g/dL, 45.60%; BMI < 20.0 kg/m(2), 36.11%) in patients with cancer. In general, there was a higher prevalence in patients with Gastrointestinal Tract Cancer (72.22%), with the stomach cancer being the most common one (29.17%). Tumors of the digestive tract presented with higher nutritional risk according to SGA (p < 0.0001), MUST (p < 0.01), BMI (p < 0,05) and serum albumin level < 3,0 g/dL (p < 0.05); these patients have twenty three times more chances of nutritional risk than patients with cancer in other organs. The patients that have also metastasis presented greater nutritional impairment, according to MUST (p < 0.05) and serum albumin level< 3,0 g/dl (p < 0,01). According to this study, we demonstrate that there is no difference between the Diagnosis of Nutritional Risk, according to MUST and SGA. However, these values are different when confronted with the ones of serum albumin level and BMI. CONCLUSION: The MUST and the Serum Albumin proved to be sensitive methods for the identification of nutritional risk in patients with metastatic cancer. The SGA and MUST tests are good diagnostic tests which presented convergence of results.
Asunto(s)
Desnutrición/diagnóstico , Desnutrición/etiología , Neoplasias/complicaciones , Estudios Transversales , Técnicas y Procedimientos Diagnósticos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Albúmina Sérica/análisisRESUMEN
The purposes of this study were to determine: a) the incorporation of labeled [3H] arachidonic acid on the intestinal mucosa, the liver and plasma, after 1,3 and 5 hours of administration, b) preferential incorporation by different tissues, c) and the effects on experimental rats with thioacetamide-induced cirrhosis, after four weeks of a dietary supplementation with nucleotides and long-chain polyunsaturated fatty acids. 209 female Wistar rats were divided into two groups (control and TAA group). The TAA group was given 300 mg of thioacetamide/L, in their drinking water for four months. After this period, a sample of 6 rats were taken from each group and examined, to evaluate the biochemical and histological changes of the experimental model, and 36 rats were taken to determine the incorporation of radioactivity by the groups. The rest of the animals were divided into four subgroups. Each group, receiving a supplementary diet with only long-chain polyunsaturated fatty acids and/or nucleotides or neither, for 4 weeks. After four months of thioacetamide, the incorporation of the [3H] arachidonic acid showed: a) an increased within 3 h in the intestinal mucosa, b) a decreased in the liver after 3 to 5 h c) and a drastic decrease in the plasma after 3 to 5 h. With a dietary supplementation of long-chain polyunsaturated fatty acids and nucleotides combined, there was a decrease of accumulate [3H] arachidonic acid in the intestine and a increase in the liver and plasma. The simultaneous supply of dietary polyunsaturated fatty acids and nucleotides was beneficial in the reversal of abnormalities of the lipid metabolism, in this experimental model of liver cirrhosis.