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1.
Nat Commun ; 11(1): 5217, 2020 10 15.
Artículo en Inglés | MEDLINE | ID: mdl-33060608

RESUMEN

The thin and flexible nature of optical fibres often makes them the ideal technology to view biological processes in-vivo, but current microendoscopic approaches are limited in spatial resolution. Here, we demonstrate a route to high resolution microendoscopy using a multicore fibre (MCF) with an adiabatic multimode-to-single-mode "photonic lantern" transition formed at the distal end by tapering. We show that distinct multimode patterns of light can be projected from the output of the lantern by individually exciting the single-mode MCF cores, and that these patterns are highly stable to fibre movement. This capability is then exploited to demonstrate a form of single-pixel imaging, where a single pixel detector is used to detect the fraction of light transmitted through the object for each multimode pattern. A custom computational imaging algorithm we call SARA-COIL is used to reconstruct the object using only the pre-measured multimode patterns themselves and the detector signals.

2.
Sensors (Basel) ; 20(2)2020 Jan 10.
Artículo en Inglés | MEDLINE | ID: mdl-31936827

RESUMEN

This paper demonstrates how research at the intersection of physics, engineering, biology and medicine can be presented in an interactive and educational way to a non-scientific audience. Interdisciplinary research with a focus on prevalent diseases provides a relatable context that can be used to engage with the public. Respiratory diseases are significant contributors to avoidable morbidity and mortality and have a growing social and economic impact. With the aim of improving lung disease understanding, new techniques in fibre-based optical endomicroscopy have been recently developed. Here, we present a novel engagement activity that resembles a bench-to-bedside pathway. The activity comprises an inexpensive educational tool (<$70) adapted from a clinical optical endomicroscopy system and tutorials that cover state-of-the-art research. The activity was co-created by high school science teachers and researchers in a collaborative way that can be implemented into any engagement development process.


Asunto(s)
Técnicas Biosensibles , Conducta Cooperativa , Fibras Ópticas , Investigación Biomédica , Humanos , Enfermedades Pulmonares/diagnóstico , Microscopía , Investigación Biomédica Traslacional
3.
Sci Total Environ ; 695: 133831, 2019 Dec 10.
Artículo en Inglés | MEDLINE | ID: mdl-31422328

RESUMEN

This article deals with stakeholders' interactions and institutional capacity influencing water resource management where competitive demands co-exist. For the case study area of Axios Delta, Northern Greece, a water deficit in the agricultural sector, an unmet environmental flow and a reduced capacity for urban supply during drought conditions are observed. An egocentric network analysis based on desk-study and a series of semi-structured stakeholder interviews reveals how weak stakeholder ties lead to ineffective multilevel governance and, as a result, low water efficiency practices. There is a lack of understanding of other users' priorities as well as of the risks related to climate change and/or seasonal variability. This is reflected in the flat rate abstraction licence for agricultural purposes which reduces environmental flow to below acceptable standards. There is no transboundary cooperation between Greece and the Republic of North Macedonia which hinders an integrated management approach. A limited exchange of information to support an evidence-based allocation plan is observed. Suitable interventions identified through a DPSIR approach are evaluated in a multi-criteria analysis considering cost effectiveness, delivered benefits as well as ease of implementation. Suitable technical practices include the development of a local and catchment-scale monitoring network for surface water and groundwater, climate-adaptive agriculture and treated-water reclamation. Updated management policies involve the institutional prioritisation of environmental flow through an adaptive allocation plan as well as the strengthening of transboundary cooperation. This research shows how the coordination of aggregated diverging interests in multilevel multi-stakeholder environments appears to be key in supporting positive water budgets in an uncertain climate future.

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