RESUMEN
This study assessed unmet service needs of rural older adults with Alzheimer's disease (AD) and identified factors that were related to these needs. Data were collected from 109 informal caregivers of AD patients. Over half of the patients experienced unmet service needs in 1 or more areas of activities of daily functioning. Informal caregiver burden and patient's gender and functional status were significantly related to patients' unmet service needs. Patients' use of formal services was marginally related to their unmet service needs. To better address patients' service needs, a comprehensive needs assessment should be conducted with both patients and their caregivers.
Asunto(s)
Envejecimiento , Enfermedad de Alzheimer/terapia , Cuidadores , Necesidades y Demandas de Servicios de Salud , Población Rural , Actividades Cotidianas , Factores de Edad , Anciano , Anciano de 80 o más Años , Femenino , Accesibilidad a los Servicios de Salud , Servicios de Salud para Ancianos , Humanos , Masculino , Persona de Mediana Edad , Análisis de Regresión , Servicio SocialRESUMEN
We determined whether pentobarbital anesthetic is required to culture postmortem adult rat neurons. Pentobarbital treatment resulted in two-fold increases in neuron survival in culture after 2 and 4 h postmortem compared to non-anesthetic controls, but was not as effective as simple postmortem treatment on ice and therefore not essential.
Asunto(s)
Corteza Cerebral/citología , Neuronas/efectos de los fármacos , Pentobarbital/farmacología , Cambios Post Mortem , Adyuvantes Anestésicos/farmacología , Animales , Técnicas de Cultivo de Célula , Supervivencia Celular/efectos de los fármacos , Proteína Ácida Fibrilar de la Glía/metabolismo , Hielo , Inmunohistoquímica/métodos , Masculino , Neuronas/citología , Fosfopiruvato Hidratasa/metabolismo , Ratas , Factores de TiempoRESUMEN
This article describes the development of the protocol for the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Alzheimer's disease trial, which was developed in collaboration with the National Institute of Mental Health to assess the effectiveness of atypical antipsychotics for psychosis and/or agitation occurring in outpatients with Alzheimer's disease. The article provides a detailed description of the methodology used in the trial as well as the clinical outcomes and effectiveness measures incorporated into it, discussing the most salient issues encountered in developing the design of the trial, as well as the unique features of the trial.