RESUMEN

Chondroitin sulphate was used to isolate from plasma a system that clotted with Russell's viper venom, brain extract and activated contact factors. Clotting appeared to depend on concomitant change in C4, C3 and C1s in the system. Brain extract additionally reacted with C9. Reconstitution of specifically defective plasmas suggested a specific role for each of these complement components in clotting.

Asunto(s)

Coagulación Sanguínea , Proteínas del Sistema Complemento/metabolismo , Reacciones Antígeno-Anticuerpo , Plaquetas/efectos de los fármacos , Sulfatos de Condroitina , Coagulantes/farmacología , Proteínas Inactivadoras del Complemento 1/metabolismo , Complemento C3/metabolismo , Complemento C4/metabolismo , Complemento C5/metabolismo , Complemento C9/metabolismo , Humanos , Técnicas In Vitro