RESUMEN

Neonatal neuroblastoma may require chemotherapy either due to mass effect or unfavourable cytogenetics. This case focuses on using pharmacokinetic (PK) guided chemotherapy to treat neonatal neuroblastoma. A newborn baby was noted to have left leg immobility. Imaging showed a retroperitoneal tumour with spinal canal extension causing spinal cord compression. PK-guided carboplatin was given after conventionally dosed chemotherapy demonstrated no improvement. After initiation of PK therapy, clinical and radiological improvement was seen. We discuss our decision to use PK-guided chemotherapy despite guidelines recommending weight-based dosing and discuss the benefits in terms of clinical efficacy without increased toxicity.

Asunto(s)

Carboplatino , Recien Nacido Prematuro , Neuroblastoma , Neoplasias Retroperitoneales , Compresión de la Médula Espinal , Carboplatino/administración & dosificación , Carboplatino/farmacocinética , Femenino , Humanos , Recién Nacido , Neuroblastoma/diagnóstico por imagen , Neuroblastoma/tratamiento farmacológico , Neuroblastoma/metabolismo , Neoplasias Retroperitoneales/diagnóstico por imagen , Neoplasias Retroperitoneales/tratamiento farmacológico , Neoplasias Retroperitoneales/metabolismo , Compresión de la Médula Espinal/diagnóstico por imagen , Compresión de la Médula Espinal/tratamiento farmacológico , Compresión de la Médula Espinal/metabolismo