RESUMEN
Perfusion of the cochlear perilymphatic space was performed in guinea pigs with complete or partial removal of K+, Na+ or Ca++ from the solution. The most obvious changes of the endocochlear potential occurred in the deficiency of Na+ in the perilymph: i. e., after a short increase the potential steadily diminished in accordance with the degree of Na+ deficit in the perilymph. The deficit of K+ in the perilymph caused a lesser and reversible reduction of the potential. The absence of Ca++ in the perilymph did not affect the potential.
Asunto(s)
Cóclea/fisiología , Electrólitos/metabolismo , Líquidos Laberínticos/metabolismo , Perilinfa/metabolismo , Animales , Calcio/metabolismo , Endolinfa/fisiología , Cobayas , Potenciales de la Membrana , Perfusión , Potasio/metabolismo , Sodio/metabolismoAsunto(s)
Cóclea/fisiología , Sulfato de Dihidroestreptomicina/farmacología , Ácido Etacrínico/farmacología , Adenosina Trifosfato/farmacología , Animales , Potenciales Microfónicos de la Cóclea/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Ácido Edético/farmacología , Endolinfa/fisiología , CobayasRESUMEN
Effects of dihydrostreptomycin, etacrine acid and ATPh on the endocochlear potential in guinea-pigs depended on the dosage and means of administration. Dihydrostreptomycin suppressed the potential only when perfusing the perilymphatic space or being microinjected into the endolymphatic duct. I. v. administration of etacrine acid suppressed the potential with its following partial restoration. I.v. administration of ATPh in large doses suppressed the potential for a short period but did not prevent the ototoxic effect of etacrine acid. ATPh in small doses did not suppress the potential but exerted the protective effect.