RESUMEN

Coagulation parameters were studied in rabbits during and after intravenous infusion of suspensions of dispersed fluorochemicals. Blood samples from rabbits given dispersed perfluorobutyltetrahydrofurane or perfluorotributylamine showed thrombocytopenia, prolongation of activated partial thromboplastin time, and decreases in Factors X and XI. The possible presence of an inhibitor of coagulation was suggested by the prolongation of prothrombin time when measured with serial dilutions of thromboplastin reagent. These abnormalities were not found in whole blood or platelet-rich plasma after incubation in vitro with dispersed fluorochemical.

Asunto(s)

Trastornos de la Coagulación Sanguínea/inducido químicamente , Butilaminas/efectos adversos , Fluorocarburos/efectos adversos , Furanos/efectos adversos , Hidrocarburos Fluorados/efectos adversos , Animales , Anticoagulantes/sangre , Plaquetas/citología , Presión Sanguínea , Recuento de Células , Factor IX/análisis , Factor V/análisis , Factor VIII/análisis , Factor X/análisis , Factor XI/análisis , Factor XII/análisis , Productos de Degradación de Fibrina-Fibrinógeno/análisis , Humanos , Conejos , Albúmina Sérica Bovina