RESUMEN
PURPOSE: Ictal piloerection is an infrequent seizure semiology that is commonly overlooked as an ictal epileptic manifestation. Piloerection is considered to be principally caused by temporal lobe activity although frontal and hypothalamic seizure origins have been reported. The described etiology has shown a wide variety of structural causes such as mesial temporal sclerosis, tumors, posttraumatic, cavernomas and cryptogenic epilepsies. METHODS: We retrospectively reviewed the incidence of ictal piloerection in the clinical records of patients who underwent video-EEG monitoring (VEEGM) between 2007 and 2013 in a multicenter cooperative study. All patients presented refractory epilepsies and were evaluated with a protocol that included brain MRI, neuropsychology and VEEGM. RESULTS: A total of 766 patients were evaluated in four tertiary centers in Spain. Five patients showed piloerection as principal seizure semiology (prevalence 0.65%). The mean age at seizure onset was 39.6 years and the average epilepsy duration was 5.2 years (range 2-14) before diagnosis. Four patients were additionally examined with FDG-PET and/or SPECT-SISCOM. All presented temporal lobe epilepsy (TLE), three right-sided and two left-sided. A typical unilateral hippocampal sclerosis was described in 3 cases. The etiology detected in all cases was limbic encephalitis. Three had LGI1, one anti-Hu, and another Ma2 antibodies. CONCLUSION: Our series describes a so far not well-recognized autoimmune association of pilomotor seizures to limbic encephalitis. This etiology should be ruled out through a comprehensive diagnostic work-up even in cases of long-lasting TLE with typical hippocampal atrophy on MRI.
Asunto(s)
Encefalitis Límbica/epidemiología , Encefalitis Límbica/fisiopatología , Piloerección/fisiología , Convulsiones/epidemiología , Convulsiones/fisiopatología , Adulto , Encéfalo/patología , Encéfalo/fisiopatología , Electroencefalografía , Femenino , Humanos , Incidencia , Encefalitis Límbica/patología , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Tomografía de Emisión de Positrones , Estudios Retrospectivos , Esclerosis , Convulsiones/patología , España/epidemiología , Tomografía Computarizada de Emisión de Fotón Único , Grabación en VideoRESUMEN
UNLABELLED: Vigabatrin (GVG) is an effective antiepileptic drug used for treating partial seizures in adults and children. Over the last years, an increasing number of articles have been published reporting visual field defects (VFD) associated with GVG therapy in adults. To date, however, only an small number of pediatric patients have been reported. This paper is a retrospective review of clinical review to evaluate the prevalence and features of VFD in pediatric patients on GVG monotherapy. METHODS: Fifteen children, on GVG therapy in the Department of Child Neurology, underwent visual field examination by static threshold automated perimetry using the Humphrey Field Analyzer Program 30-2. The age of these patients ranged from 6 to 18 years (12.4 +/- 3.6 years), 10 of them being male and five female. RESULTS: Three patients (20%) on GVG monotherapy showed VFD. These consisted in localised, bilateral, and relatively symmetrical, nasal field loss, with relative preservation of the temporal field within the central 30 degree area.
Asunto(s)
Anticonvulsivantes/efectos adversos , Vigabatrin/efectos adversos , Trastornos de la Visión/inducido químicamente , Trastornos de la Visión/fisiopatología , Campos Visuales/efectos de los fármacos , Adolescente , Automatización , Niño , Femenino , Humanos , Masculino , Estudios Retrospectivos , Trastornos de la Visión/diagnóstico , Pruebas del Campo VisualRESUMEN
El presente proyecto estudiara la factibilidad de una planta especializada en la obtencion de todo tipo de sillas de madera para exportacion. Actualmente esta empresa trabaja con madera Mara y se encuentra buscando maderas alternativas, cuenta con la maquinaria y equipo necesario y adecuado para este tipo de proceso productivo especializado. Los productos que esta empresa produce y piensa producir son: sillas y sillones coloniales Reina Ana, Chippendale, Sheraton, Jacobean, Louis XV, Georgian, Hepplewhite, Regencia, y todo tipo de sillas "en blanco" cuyo lote pedido por el cliente justifique su obtencion mediante el proceso productivo de la planta, estas se exportan a Estados Unidos, Mexico, Italia,canada, Japon y demas paises.