RESUMEN
The functional interhemispheric asymmetry of brain in patients with systemic rheumatic diseases was estimated by measuring brain direct current potentials. It is shown that different types of functional interhemispheric asymmetry correspond to different stages of systemic rheumatic diseases. At early stages, the left hemisphere asymmetry dominates, at expressed stages, the right hemisphere asymmetry is prevalent, and the terminal stage is characterized by the loss of functional interhemispheric asymmetry.
Asunto(s)
Encéfalo/patología , Enfermedades Reumáticas/patología , Encéfalo/fisiopatología , Femenino , Lateralidad Funcional , Humanos , Masculino , Potenciales de la Membrana , Enfermedades Reumáticas/fisiopatologíaRESUMEN
We studied the slow electrical activity of the brain in people subjected to irradiation as a result of the Chernobyl accident and in healthy donors. The mean constant potential, which is an index of energy metabolism in different regions of the cerebral cortex, is reliably lower in eliminators, as compared to the donors, thus suggesting a postradiation energy deficiency of the brain. The structure of correlations between the constant potential indices is different: the number of significant correlations in the group of eliminators is lower by 30% than in the group of donors, thus suggesting disturbed intercentral relations in the CNS under the conditions of postradiation energy deficiency of the brain.
Asunto(s)
Encéfalo/efectos de la radiación , Centrales Eléctricas , Liberación de Radiactividad Peligrosa , Encéfalo/fisiología , Electrodos , Electroencefalografía/instrumentación , Electroencefalografía/métodos , Electroencefalografía/efectos de la radiación , Electroencefalografía/estadística & datos numéricos , Metabolismo Energético/fisiología , Metabolismo Energético/efectos de la radiación , Humanos , Masculino , Persona de Mediana Edad , UcraniaRESUMEN
The data obtained upon examination of patients with systemic rheumatic diseases were analyzed by the methods of multiple regression and step-by-step discriminant analysis. Is was shown that the activity of autoimmune process correlates with the parameters of distribution of constant potential level in the brain of each patient, irrespective of diagnosis. The scatter of potential values was the most important predictor of activity. An increase in the activity of the autoimmune process correlated with a decrease in the scatter of potential values at recording points; the cerebral cortex became equipotential.
Asunto(s)
Autoinmunidad , Encéfalo/fisiopatología , Enfermedades Reumáticas/inmunología , Potenciales de Acción , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Reumáticas/fisiopatologíaRESUMEN
Neuroimmune interactions in systemic rheumatic diseases were studied. The state of the central nervous system was assessed from the parameters of constant brain potentials, and the state of the immune system, from a complex of immunobiochemical parameters. The highest multiple correlation coefficients were revealed between the immunobiochemical parameters and the parameters of the constant brain potential, which characterize linear and standard deviations of potentials in temporal zones from potentials at other points of recording. The results are discussed in terms of structural and functional integration of the immune and nervous systems.
Asunto(s)
Autoinmunidad , Encéfalo/fisiopatología , Enfermedades Reumáticas/inmunología , Potenciales de Acción , Adolescente , Adulto , Biomarcadores , Femenino , Humanos , Masculino , Enfermedades Reumáticas/fisiopatologíaRESUMEN
The activity of serum complement proteins and the level of steady brain potential in patients with systemic lupus erythematosus and rheumatoid arthritis were determined. The statistical analysis indicated that there is a correlation between the parameters of the complement system and neurophysiological characteristics. The differences between rheumatoid arthritis and systemic lupus erythematosus are observed in the mean values of activity of complement proteins and the steady potential, their dispersions, and the structure of correlations between immunological and neurophysiological parameters.
Asunto(s)
Artritis Reumatoide/fisiopatología , Encéfalo/fisiopatología , Proteínas del Sistema Complemento/metabolismo , Lupus Eritematoso Sistémico/fisiopatología , Potenciales de la Membrana , Artritis Reumatoide/sangre , Humanos , Lupus Eritematoso Sistémico/sangreRESUMEN
The level of the brain permanent potential as a physiological criterion of the functional interhemisphere asymmetry, as well as immunological and biochemical characteristics of peripheral blood in patients with systemic rheumatic diseases were studied. It was found that the distribution of the characteristics of immune response in patients with different types of interhemisphere asymmetry. Significant differences were observed for average values of biochemical and immunological characteristics, their dispersions, as well as for the structure of relationships between the type of the interhemisphere asymmetry and immunobiochemical characteristics.
Asunto(s)
Encéfalo/fisiopatología , Enfermedades Reumáticas/inmunología , Adolescente , Adulto , Femenino , Lateralidad Funcional , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Reumáticas/sangre , Enfermedades Reumáticas/fisiopatologíaRESUMEN
The paper is concerned with analysis of the results of combined investigation of 54 patients with focal liver lesions. USI, CT, angiography and radionuclide scintigraphy were performed. The diagnostic efficacy of USI and CT was 94.4 and 90.7%, respectively, that of scintigraphy was 68.5%, that of angiography was 55.5%. A scheme of the effective use of radiation methods in the diagnosis of sizable formations of the liver was worked out.