RESUMEN
The rapid spread of the SARS-CoV-2 Variant of Concern (VOC) Gamma in Amazonas during early 2021 fueled a second large COVID-19 epidemic wave and raised concern about the potential role of reinfections. Very few cases of reinfection associated with the VOC Gamma have been reported to date, and their potential impact on clinical, immunological, and virological parameters remains largely unexplored. Here we describe 25 cases of SARS-CoV-2 reinfection in Brazil. SARS-CoV-2 genomic analysis confirmed that individuals were primo-infected with distinct viral lineages between March and December 2020 (B.1.1, B.1.1.28, B.1.1.33, B.1.195, and P.2) and reinfected with the VOC Gamma between 3 to 12 months after primo-infection. We found a similar mean cycle threshold (Ct) value and limited intra-host viral diversity in both primo-infection and reinfection samples. Sera of 14 patients tested 10-75 days after reinfection displayed detectable neutralizing antibodies (NAb) titers against SARS-CoV-2 variants that circulated before (B.1.*), during (Gamma), and after (Delta and Omicron) the second epidemic wave in Brazil. All individuals had milder or no symptoms after reinfection, and none required hospitalization. These findings demonstrate that individuals reinfected with the VOC Gamma may display relatively high RNA viral loads at the upper respiratory tract after reinfection, thus contributing to onward viral transmissions. Despite this, our study points to a low overall risk of severe Gamma reinfections, supporting that the abrupt increase in hospital admissions and deaths observed in Amazonas and other Brazilian states during the Gamma wave was mostly driven by primary infections. Our findings also indicate that most individuals analyzed developed a high anti-SARS-CoV-2 NAb response after reinfection that may provide some protection against reinfection or disease by different SARS-CoV-2 variants.
Asunto(s)
COVID-19 , SARS-CoV-2 , Humanos , SARS-CoV-2/genética , Brasil/epidemiología , COVID-19/epidemiología , Diversidad de Anticuerpos , Rayos gamma , Reinfección , Gravedad del PacienteRESUMEN
Atualmente, as hiperlipidemias säo um dos principais fatores de risco para o infarto no miocárdio. Um dos objetivos básicos da pesquisa mundial sobre riscos cardiovasculares tem sido definiras médias de níveis lipídicos séricos e a prevalência de todos os tipos de hiperlipidemias na sociedade. O presente estudo, näo é um estudo randomizado. Tem por finalidade mostrar o comportamento dos triglicérides em 4359 pacientes examinados de janeiro a outubro de 1999. Os resultados indicam que o sexo feminino apresenta padräo de anormalidade a partir da faixa etáriaaa de 25 a 29 anos e no sexo masculino, a partir da de 20 a 24 anos de idade, o que vem sugerir, a necessidade de um controle mais efetivo, até que se determine o motivo desta alterabilidade. Os dados foram colhidos diretamente dos livros de registro de resultados do Laboratório de Bioquímica Clínica do Laboratório Central do Estado do Amazonas