RESUMEN

Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.

Asunto(s)

Cloroquina/farmacología , Resistencia a Medicamentos , Malaria Falciparum/epidemiología , Malaria Falciparum/parasitología , Carga de Parásitos , Plasmodium falciparum/efectos de los fármacos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Cloroquina/uso terapéutico , Femenino , Humanos , Lactante , Malaria Falciparum/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Vigilancia en Salud Pública , Adulto Joven , Zimbabwe/epidemiología