RESUMEN
Amino acid composition, structure, and physicochemical properties of a low-molecular-weight glycoprotein from cattle blood serum (SGP) were studied. The content of carbohydrates (represented by mannose-rich oligosaccharides) amounted to 45-50 wt %. The value of specific partial heat of SGP, measured by differential scanning calorimetry (DSC), equaled 1.8 J/g.K, which is characteristic of unfolded proteins. Circular dichroic (CD) spectra of SGP led us to conclude that it is not highly structured and that it occurs in the shape of a statistical globule. The protein was deglycated using anhydrous trifluoromethane sulfonate (TFMS), after which its amino acid composition and the sequence of a fragment were determined. The results indicate that SGP is a protein not studied previously.
Asunto(s)
Proteínas Sanguíneas/análisis , Proteínas Sanguíneas/química , Glicoproteínas/química , Animales , Proteínas Sanguíneas/aislamiento & purificación , Rastreo Diferencial de Calorimetría , Bovinos , Glicoproteínas/análisis , Glicoproteínas/aislamiento & purificación , Conformación Proteica , Análisis de SecuenciaRESUMEN
The paper discusses the efficacy of rehabilitation of 108 patients with rheumatic fever with the use of radon baths, of them in 36 in conjunction with homologous immunoglobulin. The patients were treated in a local balneological hospital. Balneotherapy has been shown to have a beneficial effect on the humoral and cellular immune response, and on factors of the body non-specific resistance in patients with unstable clinicolaboratory characteristics after the treatment for protracted rheumocarditis with minimal activity and latent course. The number of relapses and intercurrent infections were found to be decreased, and the working ability to be improved. The most pronounced effect was recorded in a group of patients who received radon baths and homologous immunoglobulin.