RESUMEN
Analysis of the experience gained during the last pandemic of 'swine' influenza A (H1N1) sw1 is presented with reference to clinical studies and etiotropic therapy. The mechanism of development of severe pneumonia as a result of mutations at the binding site of hemagglutinin receptor enhancing a2'-3'-sialoside specificity and pneumotropism of the virus is described. The data on the efficiency of Ingavirin, a new Russian antiviral for the treatment of influenza, are reported.
Asunto(s)
Subtipo H1N1 del Virus de la Influenza A , Gripe Humana/tratamiento farmacológico , Gripe Humana/fisiopatología , Oseltamivir , Neumonía Viral/tratamiento farmacológico , Tropismo Viral/genética , Zanamivir , Antivirales/administración & dosificación , Antivirales/efectos adversos , Enfermedades Transmisibles Emergentes/virología , Farmacorresistencia Viral , Diagnóstico Precoz , Hemaglutinación por Virus/genética , Humanos , Subtipo H1N1 del Virus de la Influenza A/efectos de los fármacos , Subtipo H1N1 del Virus de la Influenza A/patogenicidad , Subtipo H1N1 del Virus de la Influenza A/fisiología , Vacunas contra la Influenza/uso terapéutico , Gripe Humana/epidemiología , Gripe Humana/virología , Oseltamivir/administración & dosificación , Oseltamivir/efectos adversos , Pandemias/prevención & control , Neumonía Viral/epidemiología , Neumonía Viral/fisiopatología , Neumonía Viral/virología , Pronóstico , Índice de Severidad de la Enfermedad , Interferencia Viral , Zanamivir/administración & dosificación , Zanamivir/efectos adversosRESUMEN
Intermediatory relationships between the cholinergic and dopaminergic neurotransmission systems were analyzed using published data and the original experimental results obtained on Daphnia magna Straus, a new test object. Based on these results, the antihaloperidol activity of a series of M- cholinoblocking agents with different receptor selectivities were studied in comparison to the new cholinoblocker pentifin exceeding in the activity the classical antiparkinsonian drugs such as cyclodol, amedin, and norakin.