RESUMEN
The outbreak of cholera eltor in Yuzhno-Sakhalinsk has been analyzed. The fact of the import of this infection from China and its transmission mainly by the water route due to the intensive contamination of environmental objects has been substantiated. The effective purification decontamination of sewage water plays decisive role on the system of anticholera measures. The conclusion on the necessity of increasing the effectiveness of measures for the sanitary protection of the territory has been made.
Asunto(s)
Cólera/epidemiología , Brotes de Enfermedades , Cólera/transmisión , Humanos , Siberia/epidemiología , Microbiología del Agua , Abastecimiento de Agua/normasRESUMEN
The authors investigated in CBA mice the suppressor cell formation in spleen, induced by injection of a supraoptimal dose of sheep red blood cells and assessed their activity in a passive transfer experiment in animals with liver injury, caused by carbon tetrachloride treatment. The influence of liver explants from mice, treated with carbon tetrachloride, on antigen-induced cells, cultivated together in diffusion chambers, was also studied. It was shown that carbon tetrachloride administration inhibited the antigen-induced suppressor cells formation in murine spleen. Splenocytes, containing antigen-induced suppressor cells from mice treated with carbon tetrachloride, transferred to syngeneic mice together with an immunogeneic dose of sheep red blood cells, caused a smaller decrease of the number of antibody-forming cells in the spleen of recipients than cells from normal mice. The liver explant damaged by carbon tetrachloride, influenced splenocytes, containing antigen-induced suppressor cells (AISC). This influence depended on the degree of liver injury. These data demonstrate the role of liver injury modifying the suppressor activity of splenocytes. The decrease of suppressor cell activity may be one of the mechanisms of enhanced antibody formation in patients with liver diseases.