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BACKGROUND: The age at onset (AO) of Machado-Joseph disease (SCA3/MJD), a disorder due to an expanded CAG repeat (CAGexp) in ATXN3, is quite variable and the role of environmental factors is still unknown. Caffeine was associated with protective effects against other neurodegenerative diseases, and against SCA3/MJD in transgenic mouse models. We aimed to evaluate whether caffeine consumption and its interaction with variants of caffeine signaling/metabolization genes impact the AO of this disease. METHODS: a questionnaire on caffeine consumption was applied to adult patients and unrelated controls living in Rio Grande do Sul, Brazil. AO and CAGexp were previously determined. SNPs rs5751876 (ADORA2A), rs2298383 (ADORA2A), rs762551 (CYP1A2) and rs478597 (NOS1) were genotyped. AO of subgroups were compared, adjusting the CAGexp to 75 repeats (p < 0.05). RESULTS: 171/179 cases and 98/100 controls consumed caffeine. Cases with high and low caffeine consumption (more or less than 314.5 mg of caffeine/day) had mean (SD) AO of 35.05 (11.44) and 35.43 (10.08) years (p = 0.40). The mean (SD) AO of the subgroups produced by the presence or absence of caffeine-enhancing alleles in ADORA2A (T allele at rs5751876 and rs2298383), CYP1A2 (C allele) and NOS1 (C allele) were all similar (p between 0.069 and 0.516). DISCUSSION: Caffeine consumption was not related to changes in the AO of SCA3/MJD, either alone or in interaction with protective genotypes at ADORA2A, CYP1A2 and NOS1.

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A construção dos eixos que compõem a chamada do Dossiê "Psicanálise e Política: a insistência do Real" provocou debate instigante entre os cinco editores deste número da Revista "Estudos e Pesquisa em Psicologia".

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BACKGROUND: Tungiasis is a disease associated with extreme poverty. We aimed to evaluate the prevalence of tungiasis in six different settlements of the Sanumás indigenous community in a remote area in the Auaris region, Yanomami territory, Brazil. METHODS: We conducted an observational study to detect clinical and epidemiological factors associated with tungiasis using a cross-sectional strategy and multivariate logistic regression. Soil analysis was performed by visual and microscopic methods. RESULTS: We examined 555 persons, 45 of whom had active tungiasis; 18 cases were classified as mild, 16 as moderate and 11 as severe. The disease was significantly more prevalent in children than in adults (odds ratio (OR) 15.77; 95% confidence interval (CI) = 5.34-67.91; p < 0.001). Soil infestation was significantly related to the occurrence of human tungiasis (OR = 12.29; 95% CI = 3.75-45.88). The sex and GPS location of the houses were not related to the occurrence of tungiasis. CONCLUSIONS: We conclude that tungiasis is an important problem in the Sanumás community, especially for children. We suggest that interruption of the off-host transmission cycle, together with regular treatment [human and animal interventions], must be prioritized to achieve control of tungiasis in indigenous populations.

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Introdução: O crescimento e o desenvolvimento são eixos referenciais para todas as atividades de atenção à criança e ao adolescente. Patologias podem prejudicar o desenvolvimento motor, cognitivo, social e psicológico. A procura pelas clínicas escolas de fisioterapia vem aumentando, visto que facilitam as demandas da população e oferecem serviço de qualidade. Objetivos: Traçar o perfil dos pacientes pediátricos atendidos no decorrer do ano de 2020 a julho de 2021, na clínica escola de fisioterapia (UNIFESO), na cidade de Teresópolis. Métodos: Trata-se de uma análise descritiva, retrospectiva e quantitativa do perfil dos pacientes atendidos no ambulatório de fisioterapia, no setor de pediatria, no período de 2020 a julho de 2021, através das variáveis: faixa etária, gênero, endereço, bairro, diagnóstico clínico, tempo de tratamento e utilização de cadeiras de rodas. Resultados: A maior prevalência dos assistidos é residente do bairro Meudon-Teresópolis/RJ. A maioria das crianças foram do sexo feminino, tendo diagnóstico clínico de maior incidência o atraso neuropsicomotor. A fisioterapia motora teve dominância nos atendimentos. Conclusão: A partir da análise dos dados, serão adotadas medidas de estruturação da ficha de avaliação da pediatria, proporcionando um atendimento mais eficaz e baseado na literatura científica.

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Objetivo: avaliar a qualidade de vida e a relação com o risco de suicídio. Métodos: estudo transversal com graduandos de uma universidade pública do Brasil. A qualidade de vida foi mensurada pelo WHOQOL-Bref. Um modelo hierarquizado foi testado através de regressão linear simples. A associação da qualidade de vida com risco de suicídio foi avaliada pela Regressão de Poisson. Resultados: participaram 996 estudantes com escore médio de qualidade de vida de 61,0±13,8. Sexo feminino, cor da pele não branca, orientação sexual não heterossexual, mais pobres, com insegurança alimentar, que utilizam transporte público, com medo de violência no bairro, histórico de discriminação e insatisfeitos com o curso de graduação tiveram pior qualidade de vida, que levou à probabilidade 11 vezes maior de risco de suicídio. Conclusão: o nível de qualidade de vida da amostra estudada foi baixo, estando associado a maior vulnerabilidade socioeconômica, o que contribui para o aumento no risco de suicídio. Sugere-se o fortalecimento dos serviços de assistência estudantil das universidades como forma de promover maior qualidade de vida por meio de ações de promoção de bem-estar social, o que poderá produzir efeitos na saúde mental dos estudantes

Objective: to evaluate the quality of life and the relationship with the risk of suicide. Methods: crosssectional study with undergraduates from a public university in Brazil. Quality of life was measured by the WHOQOL-Bref. A hierarchical model was tested using simple linear regression. The association of quality of life with suicide risk was assessed by Poisson regression. Results: 996 students participated with an average quality of life score of 61.0±13.8. Female gender, non-white, non-heterosexual sexual orientation, poorer, food insecure, using public transport, fear of violence in the neighborhood, history of discrimination and dissatisfied with the undergraduate course had a worse quality of life, which led to an 11-fold increased likelihood of suicide risk. Conclusion: the level of quality of life of the sample studied was low, being associated with greater socioeconomic vulnerability, which contributes to the increased risk of suicide. It is suggested to strengthen student assistance servi-ces at universities to promote improvements in quality of life through actions to promote social wellbeing, which may have effects on students' mental health

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BACKGROUND: Cannabinoid-based therapy has been shown to be promising and is emerging as crucial for the treatment of cognitive deficits, mental illnesses, and many diseases considered incurable. There is a need to find an appropriate therapy for Alzheimer's disease, and cannabinoid-based therapy appears to be a feasible possibility. CASE PRESENTATION: This report addresses the beneficial effect of cannabinoids in microdoses on improving memory and brain functions of a patient with mild-stage Alzheimer's disease. The patient is a 75-year-old white man presenting with main symptoms of memory deficit, spatial and temporal disorientation, and limited daily activity. The experimental therapeutic intervention was carried out for 22 months with microdoses of a cannabis extract containing cannabinoids. Clinical evaluations using Mini-Mental State Examination and Alzheimer's Disease Assessment Scale-Cognitive Subscale were performed. CONCLUSIONS: Here we provide original evidence that cannabinoid microdosing could be effective as an Alzheimer's disease treatment while preventing major side effects. This is an important step toward dissociating cannabinoids' health-improving effects from potential narcotic-related limitations.

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BACKGROUND: Strategies to minimize dynamic hyperinflation (DH) and dyspnea, such as slow chest compression (SCC), are relevant in people with chronic obstructive pulmonary disease (COPD). OBJECTIVES: To analyze the acute effects of SCC after exercise on DH and dyspnea in people with COPD and to identify responders to the technique. METHODS: This is a cross-over study with 40 patients. Two six-minute step tests (6MSTs) were performed followed by a one-minute application of SCC (6MSTSCC) or rest (6MSTCONTROL), at random. End-expiratory lung volume (EELV) and dyspnea were assessed. A difference ≥76 ml in ΔEELV between SCC and control characterized the responders. RESULTS: The performance in 6MSTSCC and 6MSTCONTROL were similar. There was a greater reduction in EELV after 6MSTSCC compared to 6MSTCONTROL (124 ± 193 ml vs. 174 ± 183 ml; p = .049), while there was no difference in change in dyspnea between the SCC and control groups. Twenty-one participants were SCC responders and had higher functional residual capacity [FRC: 5.36 ± 1.09 vs. 4.58 ± 0.94; p = .02; cutoff point: 4.56; sensitivity = 76%; specificity = 53%; AUC = 0.71 (95%CI: 0.54 to 0.87); p = .02]. CONCLUSION: SCC applied immediately after exercise reduced DH, but did not reduce dyspnea in people with COPD. The technique is beneficial only for some patients and FRC can help to identify them.

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Although health-related quality of life (HRQoL) has been increasingly valued in healthcare and in clinical trials, there is scarce information about it in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). This study describes the HRQoL results obtained from ataxic SCA3/MJD subjects, and their non-ataxic offspring included in the BIGPRO (Biomarkers and genetic modifiers in a study of presymptomatic and symptomatic SCA3/MJD carriers) study. Demographic data, clinical scales, and HRQoL instruments EQ-5D-3L and SF-36 were collected. Subjects at 50% risk were genotyped in a double-blind manner. The time left until the onset of the disease was estimated for mutation carriers with a SARA < 3 and combined with disease duration of ataxic subjects (TimeToAfterOnset). Analyses were performed using PASW Statistics version 18.0, R version 4.0.0, and G*Power 3.1, and p < 0.05 was considered statistically significant. Twenty-three ataxic carriers, 33 pre-ataxic carriers, and 21 controls were enrolled. Significant differences between ataxic carriers and controls were seen in EQ-VAS, EQ-5D Index, and in some domains of EQ-5D-3L and SF-36. EQ-5D Index showed the best effect size between ataxic and controls (Cohen's d = 2.423). Stepwise changes were seen in pre-ataxic subjects, although not statistically significant. TimeToAfterOnset correlated with EQ-5D Index, EQ-VAS, and SF-36 Physical functioning, Role Physical, Pain, and General Health. EQ-5D Index and EQ-VAS correlated with clinical scales in the ataxic group. These results suggest that HRQoL worsens among carriers since pre-ataxic stages and that they might encompass the underlying disease process. In this cohort, SF-36 Physical Functioning, SF-36 General health, and especially EQ-5D Index and EQ-VAS were the best HRQoL instruments to be used as ancillary evidence to support biological and social meanings for future interventions.

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Background: A paramount factor in the control of neglected tropical diseases from both medical and social aspects is education. New strategies must be constantly pursued to test and provide educational information related to diseases affecting vulnerable populations. We applied the Q method as a model to measure educational neglect based on the burden of disseminated tungiasis. Methods: Using a saturation method for sample size calculation, we recruited students and healthcare professionals to evaluate and classify 27 statements related to the prevention, control and treatment of tungiasis. After quantitative analysis, the Q method was applied based on the paired use of the centroid method and Varimax rotation, and 4 factors were extracted representing the main sets of viewpoints among the participants. Results: We included 119 healthcare professionals with different academic degrees. Statements classified by specialists with a + agreement were also classified as a + agreement by most of the participants. However, we detected 5 important disagreements related to the topical treatment of tungiasis and control of the disease in the environment and animals. The Q method showed that almost no consensus was detected for four statements. The classification of each statement was not related to the participants' academic degree. Conclusions: There is significant educational neglect related to tungiasis prevention and treatment in healthcare sciences in Brazil. We conclude that the Q method may be an interesting strategy alone or associated with quantitative strategies for detecting educational limitations related to neglected diseases. In countries where neglected diseases are endemic, a detailed study evaluating the quality of education related to these diseases must be prioritized.

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Resumo Este artigo compreende oito cartas trocadas entre as autoras ao longo do mês de abril de 2020, tendo por eixo norteador o tema das análises online. Em uma retomada metodológica da produção teórica pela via das correspondências, amplamente utilizada entre Freud e seus interlocutores, propõe uma tessitura em ato de conceitos-acontecimentos em torno do atendimento mediado pelas tecnologias da informação e da comunicação, bem como dos deslocamentos no estatuto da escuta clínica, que reverberam especialmente sobre o inconsciente, a presença do analista e a questão do registro. A escrita epistolar possibilitou uma elaboração afetuosa e desinstitucionalizada, rompendo com a lógica academicista, sem perder o rigor conceitual do campo freudo-lacaniano na interlocução com outros autores. As discussões apresentadas refletem sobre quais vidas são passíveis de escuta nas análises, online ou não, em variados desdobramentos que circunscrevem uma clínica do contemporâneo.

Abstract This essay consists of eight letters exchanged between the authors over the course of April 2020, on the topic of online analysis. Resuming the methodological approach of theoretical production via correspondence, widely used by Freud and his interlocutors, the article weaves concepts-events regarding psychological care mediated by information and communication technologies, as well as shifts in the status of clinical listening, which reverberate especially on the unconscious, the presence of the analyst and issue of recording. The epistolary writing enabled an affectionate and deinstitutionalized elaboration, breaking with academic logic, without losing the conceptual rigor of the Freudian-Lacanian field in dialogue with other authors. The discussions presented reflect on which lives can be heard in analysis, online or otherwise, in varying unfoldings that circumscribe a contemporary clinic.

Resumen Este artículo consta de ocho cartas intercambiadas entre las autoras durante el mes de abril de 2020, teniendo como eje central el tema de los análisis en línea. En una retomada metodológica de la producción teórica a través de las correspondencias, ampliamente utilizadas entre Freud y sus interlocutores, se propone una costura en acto de conceptos acontecimientos sobre la atención mediada por las tecnologías de la información y la comunicación, así como de los desplazamientos en el estatuto de la escucha clínica, que repercute especialmente en el inconsciente, la presencia del analista y la cuestión del registro. La escritura epistolar posibilitó una elaboración afectuosa y no institucional, rompiendo con la lógica academicista, sin perder el rigor conceptual con el campo freudo-lacaniano en la interlocución con otros autores. Las discusiones que se presentan aquí reflexionan sobre cuáles vidas son susceptibles de escucha en los análisis, en línea o no, en diversos desplazamientos en materia de una clínica de la contemporaneidad.

Résumé Cet essai comprend huit lettres échangées entre les autrices au cours du mois d'avril 2020, sur le thème de l'analyse en ligne. Reprenant l'approche méthodologique de la production théorique par correspondance, largement utilisée par Freud et ses interlocuteurs, l'article tisse des concepts-événements concernant le soin psychologique médiatisé par les technologies de l'information et de la communication, ainsi que des déplacements du statut de l'écoute clinique, qui se répercutent notamment sur l'inconscient, la présence de l'analyste et la question de l'enregistrement. L'écriture épistolaire a permis une élaboration affectueuse et désinstitutionnalisée, en rupture avec la logique académique, sans perdre la rigueur conceptuelle du champ freudo-lacanien en dialogue avec d'autres auteurs. Les discussions présentées réfléchissent sur les vies qui peuvent être entendues en analyse, en ligne ou non, dans des déroulements divers qui circonscrivent une clinique du contemporain.

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OBJECTIVE: The aim was to investigate the acute effect of kinesthetic motor imagery of the 2-minute walk test on hemodynamic and cardiopulmonary variables in patients with heart failure. METHODS: Twenty participants were recruited for the analysis of these variables before and after the execution and imagination of the 2-minute walk test, with the number of laps executed and imagined being recorded. RESULTS: The main results observed showed that (1) there was no difference in the number of laps executed and imagined (p=0.41), indicating that the participants actually imagined the test and (2) the motor imagery of the 2-minute walk test immediately increased (p<0.001) the heart and respiratory rates. CONCLUSION: The motor imagery seems to have acute effects on the cardiopulmonary anticipatory responses of a patient with heart failure.

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The high levels of biodiversity in the Amazon are maintained mostly due to its composition as a natural mosaic of different habitats, including both unflooded and flooded forests, campinaranas, and savannahs. Here, we compared multiple dimensions of α- and ß- bat biodiversity between four natural Amazonian habitats (savannah, campinarana, forest patches, and continuous forest). In addition, we explored the extent to which bat communities in the different habitats are nested within one another, and compared the community-level functional uniqueness and community-weighted mean traits between habitats. Our results show that taxonomic, functional and phylogenetic α-diversity of bats is higher in continuous forest than in any of the other habitat types. The continuous forest also harbours more unique species, and indeed, the bat community assemblages in the less-complex habitats, including forest patches, campinarana and savannahs, are taxonomic, functional and phylogenetic sub-sets of the assemblage found in the continuous forest. By examining ß-diversity partitions and species composition, we are able to shed light on the mechanisms behind the variation in diversity between the four habitat types, which reflect a process of environmental sorting along a habitat gradient going from a more complex to a less complex habitat. We conclude that nesting patterns along the mosaic of habitats are determined by differences in complexity between habitats and that taxonomic and functional uniqueness contribute to overall regional bat diversity and functionality. Ongoing human-induced disturbances of these habitats could provoke an unprecedented loss of bat diversity and functionality with negative consequences for biodiversity and ecosystem services.

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BACKGROUND: Tungiasis is a neglected disease caused by Tunga penetrans that can be complicated by secondary infections and local tissue destruction. Adequate treatment is important, especially in vulnerable populations; potential treatment options proposed range from surgical extraction to the use of oral and topical medications. We aimed to perform a systematic review to assess the efficacy of topical, oral and surgical interventions for the treatment of tungiasis. METHODOLOGY/PRINCIPAL FINDINGS: The present review is registered in PROSPERO (CRD42021234741). On September 1, 2020, we searched PubMed, EMBASE, Scopus, Web of Science, Science Direct, Scielo and LILACS BVS. We included clinical trials and longitudinal observational studies that evaluated any topical, systemic or mechanical treatment for tungiasis. We used the Revised Cochrane Risk of Bias (RoB) Tool for Randomized Trials for clinical trial analysis. Qualitative and quantitative descriptive syntheses were performed. Our search strategy resulted in 3376 references. Subsequently, 2568 titles/abstracts and 114 full texts were screened. We finally included 19 articles; 9 were classified as clinical trials. Two and 3 articles presented low and some RoB, respectively, according to the tool. Only two articles tested the efficacy of oral medications (niridazole, ivermectin), with discouraging results. Six clinical trials evaluated topical products for the treatment of tungiasis; 2 evaluated dimeticone-based compounds and reported positive results in lesion reduction and cure. None reported significant adverse reactions. Surgical extraction was evaluated only in observational studies. CONCLUSIONS/SIGNIFICANCE: We conclude that, although surgical extraction is the most commonly used treatment, there is sufficient evidence supporting the use of occlusive agents, especially manufactured dimeticone-based products.

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Calpain-mediated proteolysis has been proposed to modulate the pathogenesis of spinocerebellar ataxia type 3, also known as Machado-Joseph disease (SCA3/MJD), a disorder due to a CAG repeat expansion (CAGexp) at ATXN3. We aimed to investigate if single-nucleotide polymorphisms (SNPs) at calpain gene CAPN2 and at calpastatin gene CAST modulate the age at onset (AO) and disease progression in SCA3/MJD. A total of 287 SCA3/MJD symptomatic subjects (151 families) were included. AO was analyzed and controlled by the CAG repeat length of expanded allele and family. Candidate polymorphisms were chosen based on the literature and on a priori criteria. The CAG repeat length and SNPs were genotyped according to standard methods. AO of carriers of AA and AG + GGrs1559085 genotypes in CAST and with the median value of 75 repeats at the expanded allele were 34.23 (33.07-35.38) and 36.42 years (34.50-38.34), respectively (p = 0.049, mixed model treating the expanded CAG repeat size as fixed effect and family as random effect). Carriers of haplotype Crs27852/Grs1559085 had mean AO of 37.23 (12.76) and 33.42 years (12.20) (p = 0.047, Student's t test). Our data suggest an association between allele Grs1559085 and haplotype Crs27852/Grs1559085 at CAST and variations in the AO of SCA3/MJD subjects, independent from the effects of the CAGexp and family. The present results support the potential role of calpain cleavage pathway over modulation of SCA3/MJD phenotype.

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BACKGROUND: The pathological burden of spinocerebellar ataxia type 3, also known as Machado-Joseph disease (SCA3/MJD), accumulates before the beginning of symptoms. Our study aims at validating biomarkers for disease progression since pre-ataxic periods. We report on baseline findings of clinical scales and oculomotor neurophysiology. METHODS: Ataxic (Scale for the Assessment and Rating of Ataxia > 2.5) and at 50% risk subjects were included. The latter were subdivided into noncarriers, pre-ataxic carriers near (PAN), or pre-ataxic carriers far from (PAFF) ataxia onset (AO), with 4 years from the predicted age at onset being the cutoff. The subjects were assessed by Neurological Examination Score for Spinocerebellar Ataxia (NESSCA), International Cooperative Ataxia Rating Scale (ICARS), Inventory of Non-Ataxic Signs (INAScount), Composite Cerebellar Functions Score and SCA Functional Index, and video-oculography, including the regression slope of vestibulo-ocular reflex gain (VORr), main sequence of volitional and reflexive vertical saccades, slow-phase velocity of central and gaze-evoked (SPV-GE) nystagmus, and vertical pursuit gain. Correction for multiple comparisons was performed; the threshold for statistical significance was P < 0.05. RESULTS: A total of 35 ataxic, 14 PAN, 24 PAFF, and 22 noncarriers were included. All variables showed significant differences between groups and correlated to time to onset or time after onset, among all 73 SCA3/MJD carriers; none significantly changed with age in controls. NESSCA, ICARS, INAScount, VORr, main sequence of volitional saccades, and SPV-GE not only distinguished PAN from controls but also correlated with time left to AO. CONCLUSIONS: Clinical scales and video-oculography variables were already altered in pre-ataxic SCA3/MJD carriers and worsened with time. NESSCA, ICARS, INAScount, VORr, main sequence of vertical volitional saccades, and SPV-GE are good candidates to measure preclinical changes in SCA3/MJD. © 2021 International Parkinson and Movement Disorder Society.

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BACKGROUND: Functional capacity assessment is important in patients with chronic obstructive pulmonary disease (COPD). It can be performed by the six-minute walk test (6MWT) on a 30-meter track. However, such space is not always available in clinical settings. OBJECTIVES: To compare the performance between the 6MWT on a 30- (6MWT30) and 20-meter (6MWT20) track; to evaluate the validity and reliability of the 6MWT30 and the 6MWT20; and to determine for which patients track length has the greatest impact on performance. METHODS: Patients with COPD randomly performed two 6MWT30 and two 6MWT20 on two different days and were also assessed using the COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) scale. RESULTS: Thirty patients (23 men; mean ±â€¯standard deviation FEV1%pred: 45.6 ±â€¯12.1) participated in the study. They walked a greater distance on the 6MWT30 than on the 6MWT20 [mean difference: 22.1 m (95% CI: 12, 32 m)]. The longer the 6MWT30 distance, the greater the difference between the 2 tests (r = 0.51; p = 0.004). The 6MWT20 showed high reliability [ICC: 0.96 (95% CI: 0.77, 0.99)] and the results were associated with the distance walked on the 6MWT30 (r = 0.86), CAT (r = -0.53), and mMRC (r = -0.62). Patients who walked ≥430 m in the 6MWT30 presented a difference between the tests greater than those who walked <430 m (34.5 ±â€¯23.3 m vs. 12.6 ±â€¯24.1 m; respectively; p = 0.01). CONCLUSIONS: Performance was higher on the 6MWT30, with the difference increasing as performance improved. Therefore, the 6MWT20 is valid and reliable to evaluate functional capacity but should not be considered interchangeable with the 6MWT30, especially for the less disabled patients with COPD.

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O que causa nossa comoção diante de uma morte? Por que Clarice Lispector conta os tiros que mataram Mineirinho e uma parcela da população conta os dias da morte de Marielle Franco? Essas são indagações que guiam um olhar psicanalítico para a comoção exposta na crônica Mineirinho, de Clarice, oportunidade em que se realiza um entrelaçamento da psicanálise com a obra literária. Além dessa abordagem, busca-se uma relação entre a narrativa da crônica e o conceito de comoção e vida precária em Judith Butler. Há também um diálogo entre o que traz Butler e a ética trágica da psicanálise.(AU)

What causes our commotion before death? Why does Clarice Lispector count how many shots killed Mineirinho and part of the population counts the days since Marielle Franco’s death? These are questions that guide the psychoanalytical look at the commotion exposed in Clarice’s chronicle Mineirinho, when there is an interlacing between psychoanalysis and the literary work. Beyond this approach, there is a search for a relation between the chronicle and the concepts of commotion and precarious life as defined by Judith Butler. There is also a dialogue between what Butler brings and the tragic ethics of psychoanalysis.(AU)

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O objetivo do trabalho foi avaliar diferentes níveis de inclusão de farelo de algodão na alimentação de codornas japonesas. Foram utilizadas 240 codornas japonesas distribuídas em delineamento inteiramente casualizado com cinco tratamentos e seis repetições, com oito codornas por repetição. Os tratamentos utilizados foram: dieta basal com 0% de farelo de algodão; inclusão de 4% de farelo de algodão; 8% de farelo de algodão; 12% de farelo de algodão e 16% de farelo de algodão. Foram avaliados o consumo de ração individual (g/ave/dia), taxa de postura (%), conversão alimentar por dúzia de ovos (kg/dz), conversão alimentar por massa de ovos (kg/kg), viabilidade das aves, ganho de peso. As variáveis para a qualidade do ovo foram: peso do ovo (g), peso da gema (g), peso da casca (g) peso do albúmen, participação percentual da gema, casca e albúmen, gravidade específica (g/cm3). Para consumo individual de ração (g/ave/dia), peso de gema (g), albúmen, percentual da gema, casca e albúmen houve influência (P<0,05) do farelo de algodão na dieta, para as demais variáveis não foi observada diferença significativa (P>0,05). O farelo de algodão pode ser adicionado na dieta de codornas japonesas, sem prejudicar o desempenho e a qualidade dos ovos.(AU)

The objective of this study was to evaluate different levels of inclusion of cottonseed meal in the diet of Japanese quail. Twenty Japanese quails were used in a completely randomized design consisting of five treatments and six replicates, with eight quails per replicate. The treatments used were: basal diet with 0% cottonseed meal; inclusion of 4% cottonseed meal, 8% cottonseed meal, 12% cottonseed meal, and 16% cottonseed meal. Feed intake per egg mass (kg/dz), feed conversion per egg mass (kg/kg), viability of birds, and weight gain were evaluated. The egg quality variables were: egg weight (g), yolk weight (g), eggshell weight (g) albumen weight, percentage of yolk, eggshell and albumen, and specific gravity (g/cm3). Cottonseed meal in the diet influenced (P<0.05) individual feed intake (g/bird/day), yolk weight (g), albumen, and percentage of yolk, eggshell and albumen. No significant difference was observed for the other variables (P>0.05). Cottonseed meal can be added to the diet of Japanese quail without compromising performance or egg quality.(AU)

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Spinocerebellar ataxias (SCAs) comprise a heterogeneous group of autosomal dominant disorders. The relative frequency of the different SCA subtypes varies broadly among different geographical and ethnic groups as result of genetic drifts. This review aims to provide an update regarding SCA founders in the American continents and the Caribbean as well as to discuss characteristics of these populations. Clusters of SCAs were detected in Eastern regions of Cuba for SCA2, in South Brazil for SCA3/MJD, and in Southeast regions of Mexico for SCA7. Prevalence rates were obtained and reached 154 (municipality of Báguano, Cuba), 166 (General Câmara, Brazil), and 423 (Tlaltetela, Mexico) patients/100,000 for SCA2, SCA3/MJD, and SCA7, respectively. In contrast, the scattered families with spinocerebellar ataxia type 10 (SCA10) reported all over North and South Americas have been associated to a common Native American ancestry that may have risen in East Asia and migrated to Americas 10,000 to 20,000 years ago. The comprehensive review showed that for each of these SCAs corresponded at least the development of one study group with a large production of scientific evidence often generalizable to all carriers of these conditions. Clusters of SCA populations in the American continents and the Caribbean provide unusual opportunity to gain insights into clinical and genetic characteristics of these disorders. Furthermore, the presence of large populations of patients living close to study centers can favor the development of meaningful clinical trials, which will impact on therapies and on quality of life of SCA carriers worldwide.

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