RESUMEN

Se realizó un estudio observacional, descriptivo y transversal de 12 pacientes ingresados con diagnóstico de pulmón húmedo traumático en la Unidad de Cuidados Intensivos del Hospital Provincial Clinicoquirúrgico Docente Saturnino Lora de Santiago de Cuba durante el 2007, a los cuales se aplicó ventilación mecánica no invasiva según el protocolo establecido. En la casuística predominaron los pacientes jóvenes del sexo masculino. A las 24 horas del tratamiento con la mencionada ventilación disminuyeron las manifestaciones clínicas siguientes: frecuencias respiratoria y cardíaca, tiraje, cianosis, aleteo nasal y pausas al hablar. Los valores hemogasométricos obtenidos evidenciaron cambios favorables significativos. En un solo paciente se produjo rechazo de la interfase, no se presentaron grandes complicaciones y la evolución fue satisfactoria en 83,3 por ciento de la casuística. La terapéutica aplicada mejoró la relación ventilación-perfusión, así como incrementó la difusión de gases a través de la membrana alvéolo-capilar y la oxigenación tisular; pero las acciones de enfermería intensiva fueron vitales en ello(AU)

A descriptive, observational, and cross-sectional study of 12 patients with traumatic wet lung diagnosis hospitalized at the Intensive Care Unit from Saturnino Lora Provincial Clinical Surgical Teaching Hospital in Santiago de Cuba was carried out during the year 2007. Non-invasive mechanical ventilation was applied to those patients following the established protocol. Young male patients prevailed in the case material. Clinical manifestations, such as: respiratory and cardiac frequencies, chest indrawing, nasal flaring, and gaps in speech decreased when using the aforementioned ventilation after 24 hours. The obtained hemogasometric values showed significant and favorable changes. Interface rejection was observed in just one patient. There were no major complications and clinical course was satisfactory in 83,3 percent of the case material. The applied therapy allowed the improvement of the relationship between ventilation and perfusion, as well as the increase of gas diffusion through alveolar-capillary membrane and tissular oxygenation. Intensive nursing actions were vital to achieve these results(AU)

Asunto(s)

RESUMEN

Se realizó un estudio observacional, descriptivo y transversal de 12 pacientes ingresados con diagnóstico de pulmón húmedo traumático en la Unidad de Cuidados Intensivos del Hospital Provincial Clinicoquirúrgico Docente Saturnino Lora de Santiago de Cuba durante el 2007, a los cuales se aplicó ventilación mecánica no invasiva según el protocolo establecido. En la casuística predominaron los pacientes jóvenes del sexo masculino. A las 24 horas del tratamiento con la mencionada ventilación disminuyeron las manifestaciones clínicas siguientes: frecuencias respiratoria y cardíaca, tiraje, cianosis, aleteo nasal y pausas al hablar. Los valores hemogasométricos obtenidos evidenciaron cambios favorables significativos. En un solo paciente se produjo rechazo de la interfase, no se presentaron grandes complicaciones y la evolución fue satisfactoria en 83,3 por ciento de la casuística. La terapéutica aplicada mejoró la relación ventilación-perfusión, así como incrementó la difusión de gases a través de la membrana alvéolo-capilar y la oxigenación tisular; pero las acciones de enfermería intensiva fueron vitales en ello.

A descriptive, observational, and cross-sectional study of 12 patients with traumatic wet lung diagnosis hospitalized at the Intensive Care Unit from Saturnino Lora Provincial Clinical Surgical Teaching Hospital in Santiago de Cuba was carried out during the year 2007. Non-invasive mechanical ventilation was applied to those patients following the established protocol. Young male patients prevailed in the case material. Clinical manifestations, such as: respiratory and cardiac frequencies, chest indrawing, nasal flaring, and gaps in speech decreased when using the aforementioned ventilation after 24 hours. The obtained hemogasometric values showed significant and favorable changes. Interface rejection was observed in just one patient. There were no major complications and clinical course was satisfactory in 83,3 percent of the case material. The applied therapy allowed the improvement of the relationship between ventilation and perfusion, as well as the increase of gas diffusion through alveolar-capillary membrane and tissular oxygenation. Intensive nursing actions were vital to achieve these results.

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RESUMEN

A novel approach (TOMOCOMD-CARDD) to computer-aided "rational" drug design is illustrated. This approach is based on the calculation of the non-stochastic and stochastic linear indices of the molecular pseudograph's atom-adjacency matrix representing molecular structures. These TOMOCOMD-CARDD descriptors are introduced for the computational (virtual) screening and "rational" selection of new lead antibacterial agents using linear discrimination analysis. The two structure-based antibacterial-activity classification models, including non-stochastic and stochastic indices, classify correctly 91.61% and 90.75%, respectively, of 1525 chemicals in training sets. These models show high Matthews correlation coefficients (MCC=0.84 and 0.82). An external validation process was carried out to assess the robustness and predictive power of the model obtained. These QSAR models permit the correct classification of 91.49% and 89.31% of 505 compounds in an external test set, yielding MCCs of 0.84 and 0.79, respectively. The TOMOCOMD-CARDD approach compares satisfactorily with respect to nine of the most useful models for antimicrobial selection reported to date. Finally, an in silico screening of 87 new chemicals reported in the anti-infective field with antibacterial activities is developed showing the ability of the TOMOCOMD-CARDD models to identify new lead antibacterial compounds.

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RESUMEN

The TOpological MOlecular COMputer Design (TOMOCOMD-CARDD) approach has been introduced for the classification and design of antimicrobial agents using computer-aided molecular design. For this propose, atom, atom-type, and total quadratic indices have been generalized to codify chemical structure information. In this sense, stochastic quadratic indices have been introduced for the description of the molecular structure. These stochastic fingerprints are based on a simple model for the intramolecular movement of all valence-bond electrons. In this work, a complete data set containing 1006 antimicrobial agents is collected and presented. Two structure-based antibacterial activity classification models have been generated. The models (including nonstochastic and stochastic indices) classify correctly more than 90% of 1525 compounds in training sets. These models permit the correct classification of 92.28% and 89.31% of 505 compounds in an external test sets. The TOMOCOMD-CARDD approach, also, satisfactorily compares with respect to nine of the most useful models for antimicrobial selection reported to date. Finally, a virtual screening of 87 new compounds reported in the antiinfective field with antibacterial activities is developed showing the ability of the TOMOCOMD-CARDD models to identify new leads as antibacterial.

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