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Alkyldimethylbenzylammonium chlorides (ADBACs), classified as second-generation quaternary ammonium compounds, are extensively employed across various sectors, encompassing veterinary medicine, food production, pharmaceuticals, cosmetics, ophthalmology, and agriculture. Consequently, significant volumes of ADBAC C12-C16 are discharged into the environment, posing a threat to aquatic organisms. Regrettably, comprehensive data regarding the toxicological characteristics of these compounds remain scarce. This research aimed to determine whether or not ADBAC C12-C16, at environmentally relevant concentrations (0.4, 0.8, and 1.6 µg/L), may instigate oxidative stress and alter the expression of apoptosis-related genes in the liver, brain, gut, and gills of Danio rerio adults (5-6 months). The findings revealed that ADBAC C12-C16 elicited an oxidative stress response across all examined organs following 96 h of exposure. Nonetheless, the magnitude of this response varied among organs, with the gills exhibiting the highest degree of susceptibility, followed by the gut, liver, and brain, in descending order. Only the gut and gills of the examined organs displayed a concentration-dependent reduction in the activity of superoxide dismutase (SOD) and catalase (CAT). Akin to the oxidative stress response, all organs exhibited a marked increase in bax, blc2, casp3, and p53 expression levels. However, the gills and gut manifested a distinctive suppression in the expression of nrf1 and nrf2. Our Principal Component Analysis (PCA) confirmed that SOD, CAT, nrf1, and nrf2 were negatively correlated to oxidative damage biomarkers and apoptosis-related genes in the gills and gut; meanwhile, in the remaining organs, all biomarkers were extensively correlated. From the above, it can be concluded that ADBAC C12-C16 in low and environmental concentrations may threaten the health of freshwater fish.

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The remote monitoring of vital signs and healthcare provision has become an urgent necessity due to the impact of the COVID-19 pandemic on the world. Blood oxygen level, heart rate, and body temperature data are crucial for managing the disease and ensuring timely medical care. This study proposes a low-cost wearable device employing non-contact sensors to monitor, process, and visualize critical variables, focusing on body temperature measurement as a key health indicator. The wearable device developed offers a non-invasive and continuous method to gather wrist and forehead temperature data. However, since there is a discrepancy between wrist and actual forehead temperature, this study incorporates statistical methods and machine learning to estimate the core forehead temperature from the wrist. This research collects 2130 samples from 30 volunteers, and both the statistical least squares method and machine learning via linear regression are applied to analyze these data. It is observed that all models achieve a significant fit, but the third-degree polynomial model stands out in both approaches. It achieves an R2 value of 0.9769 in the statistical analysis and 0.9791 in machine learning.

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PURPOSE: Multiple myeloma (MM) is a highly heterogeneous, incurable disease most frequently diagnosed in the elderly. Therefore, data on clinical characteristics and outcomes in the very young population are scarce. PATIENTS AND METHODS: We analyzed clinical characteristics, response to treatment, and survival in 103 patients with newly diagnosed MM age 40 years or younger compared with 256 patients age 41-50 years and 957 patients age 51 years or older. RESULTS: There were no statistical differences in sex, isotype, International Scoring System, renal involvement, hypercalcemia, anemia, dialysis, bony lesions, extramedullary disease, and lactate dehydrogenase (LDH). The most used regimen in young patients was cyclophosphamide, bortezomib, dexamethasone, followed by cyclophosphamide, thalidomide, dexamethasone and bortezomib, thalidomide, dexamethasone. Of the patients age 40 years or younger, only 53% received autologous stem-cell transplant (ASCT) and 71.1% received maintenance. There were no differences in overall survival (OS) in the three patient cohorts. In the multivariate analysis, only high LDH, high cytogenetic risk, and ASCT were statistically associated with survival. CONCLUSION: In conclusion, younger patients with MM in Latin America have similar clinical characteristics, responses, and OS compared with the elderly.

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According to the literature, biobehavioural interventions or combined strategies would reduce the risk of HIV infection by more than 7,000 new cases each day, which would contribute to the battle facing Latin America, where despite the high incidence and prevalence of HIV in the region, access to PrEP (pre-exposure prophylaxis) is very limited. The objective of this research was, consistent with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), to conduct a scoping review to assess the evidence of available outcome data on biobehavioural interventions and programs to address gaps in the PrEP continuum of care in Latin America. The search was conducted in the databases EBSCOhost, WoS, Scopus, and ProQuest, and include all studies published from 2010 to 2021. One hundred eighty-six studies were identified and evaluated according to the eligibility criteria in six stages starting with the elimination of duplicates until the selection of studies that met the previously mentioned criteria; at the end five studies were chosen which were submitted to the methodological quality assessment including compliance with ethical guidelines. Results show that biobehavioural interventions promoting PrEP in Latin America are effective in increasing condom use, decreasing HIV risk, and increasing PrEP awareness, uptake, adherence, and retention. The limited number of interventions in the PrEP continuum of care indicates a need for the uptake of dissemination and implementation science (D&I) frameworks. D&I could help facilitate the translation of evidence-based practices, interventions, and policies to address the HIV crisis in Latin America.

Según la literatura, las intervenciones bioconductuales o estrategias combinadas reducirían el riesgo de infección por VIH en más de 7000 nuevos casos cada día, lo que contribuiría a la batalla que enfrenta América Latina, región en la que, a pesar de la alta incidencia y prevalencia del VIH, el acceso a la PrEP (profilaxis preexposición) es muy limitado. De acuerdo con las directrices de PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), el objetivo de esta investigación fue realizar una revisión de alcance para evaluar la evidencia de los datos de resultados disponibles sobre intervenciones bioconductuales y programas para abordar las brechas en el continuo de atención de PrEP en América Latina. La búsqueda se realizó en las bases de datos EBSCOhost, WoS, Scopus y ProQuest, e incluyó todos los estudios publicados de 2010 a 2021. Se identificaron ciento ochenta y seis estudios, y se evaluaron de acuerdo con los criterios de elegibilidad en seis etapas, iniciando por la eliminación de duplicados hasta la selección de estudios que cumplieran los criterios previamente mencionados; al final se eligieron cinco estudios, los cuales fueron sometidos a la evaluación de calidad metodológica, incluyendo el cumplimiento de los lineamientos éticos. Los resultados muestran que las intervenciones bioconductuales que promueven la PrEP en América Latina son efectivas para aumentar el uso del condón, disminuir el riesgo de VIH y aumentar la conciencia, la aceptación, la adherencia y la retención de la PrEP. El número limitado de intervenciones en el continuo de atención de la PrEP indica la necesidad de adoptar marcos científicos de difusión e implementación (D&I); marcos que podrían ayudar a facilitar la traducción de prácticas, intervenciones y políticas basadas en la evidencia para abordar la crisis del VIH en América Latina.

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According to the literature, biobehavioural interventions or combined strategies would reduce the risk of HIV infection by more than 7,000 new cases each day, which would contribute to the battle facing Latin America, where despite the high incidence and prevalence of HIV in the region, access to PrEP (pre-exposure prophylaxis) is very limited. The objective of this research was, consistent with the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), to conduct a scoping review to assess the evidence of available outcome data on biobehavioural interventions and programs to address gaps in the PrEP continuum of care in Latin America. The search was conducted in the databases EBSCOhost, WoS, Scopus, and ProQuest, and include all studies published from 2010 to 2021. One hundred eighty-six studies were identified and evaluated according to the eligibility criteria in six stages starting with the elimination of duplicates until the selection of studies that met the previously mentioned criteria; at the end five studies were chosen which were submitted to the methodological quality assessment including compliance with ethical guidelines. Results show that biobehavioural interventions promoting PrEP in Latin America are effective in increasing condom use, decreasing HIV risk, and increasing PrEP awareness, uptake, adherence, and retention. The limited number of interventions in the PrEP continuum of care indicates a need for the uptake of dissemination and implementation science (D&I) frameworks. D&I could help facilitate the translation of evidence-based practices, interventions, and policies to address the HIV crisis in Latin America.

Según la literatura, las intervenciones bioconductuales o estrategias combinadas reducirían el riesgo de infección por VIH en más de 7000 nuevos casos cada día, lo que contribuiría a la batalla que enfrenta América Latina, región en la que, a pesar de la alta incidencia y prevalencia del VIH, el acceso a la PrEP (profilaxis preexposición) es muy limitado. De acuerdo con las directrices de PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), el objetivo de esta investigación fue realizar una revisión de alcance para evaluar la evidencia de los datos de resultados disponibles sobre intervenciones bioconductuales y programas para abordar las brechas en el continuo de atención de PrEP en América Latina. La búsqueda se realizó en las bases de datos EBSCOhost, WoS, Scopus y ProQuest, e incluyó todos los estudios publicados de 2010 a 2021. Se identificaron ciento ochenta y seis estudios, y se evaluaron de acuerdo con los criterios de elegibilidad en seis etapas, iniciando por la eliminación de duplicados hasta la selección de estudios que cumplieran los criterios previamente mencionados; al final se eligieron cinco estudios, los cuales fueron sometidos a la evaluación de calidad metodológica, incluyendo el cumplimiento de los lineamientos éticos. Los resultados muestran que las intervenciones bioconductuales que promueven la PrEP en América Latina son efectivas para aumentar el uso del condón, disminuir el riesgo de VIH y aumentar la conciencia, la aceptación, la adherencia y la retención de la PrEP. El número limitado de intervenciones en el continuo de atención de la PrEP indica la necesidad de adoptar marcos científicos de difusión e implementación (D&I); marcos que podrían ayudar a facilitar la traducción de prácticas, intervenciones y políticas basadas en la evidencia para abordar la crisis del VIH en América Latina.

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In a context that has tended towards globalization, in which obtaining economic resources is usually the driving force of societies, information resources have frequently been treated as private goods for which one must pay. A strategy for the above has been open and free access to information, a factor of great importance for the construction of more open media.

En un contexto que ha tendido a lo globalizado, en el que la obtención de recursos económicos suele ser el motor de las sociedades, los recursos de información han sido tratados con frecuencia como bienes privados por los que hay que pagar. Una estrategia a lo anterior ha sido el acceso abierto y gratuito a la información, un factor de gran importancia para la construcción de medios más abiertos.

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RESUMEN Objetivo: Describir, de acuerdo con la literatura actual, las características clínico-demográficas y los tratamientos farmacológicos y no farmacológicos en los cambios cognitivos desarrollados después de la infección por el SARS-CoV-2. Material y métodos: Realizamos una búsqueda no sistemática en Medline (PubMed), con el objetivo de encontrar información sobre conceptos actualizados en definiciones clínicas, fisiopatología, características clínicas y estrategias terapéuticas, para lo cual se utilizó términos MeSH y se consideró artículos publicados desde el año 2020 sobre el deterioro cognitivo post-COVID-19. Resultados: Los factores de riesgo asociados incluyen sexo femenino, enfermedades crónicas, tabaquismo y antecedentes de hospitalización. Dentro de los dominios cognitivos más afectados se encuentran la memoria, la atención y las funciones ejecutivas. Los dominios cognitivos menos afectados son el lenguaje y las habilidades visoespaciales. Los estudios de neuroimagen han demostrado ser de utilidad para determinar correlaciones anatómicas con el deterioro cognitivo. Las terapias farmacológicas y otras estrategias no farmacológicas no cuentan con suficiente nivel de evidencia para demostrar su efectividad contra el deterioro cognitivo. La rehabilitación cognitiva y la psicoterapia pueden ayudar a mejorar el deterioro cognitivo y también algunos síntomas neuropsiquiátricos. Conclusiones: La caracterización de las definiciones y el espectro clínico-cognitivo como complicación post-COVID-19 están más estructurados en la actualidad; sin embargo, aún no se cuenta con suficiente nivel de evidencia para poder desarrollar guías de tratamiento estandarizadas para el deterioro cognitivo. El manejo interdisciplinario con rehabilitación neurocognitiva, fármacos, neuromodulación y otras terapias podría aportar mejoras en el pronóstico del déficit cognitivo.

ABSTRACT The objective of this review is to describe, in accordance with the current literature, the demographic-clinical characteristics, pharmacological and non-pharmacological treatments in the cognitive changes developed after infection by the SARS-CoV-2. Method, we conducted a non-systematic search in MEDLINE (PubMed) with the aim of finding bibliography including original studies describing current concepts in clinical definitions, pathophysiology, clinical features and therapeutic strategies. Utilizing MeSH terminology, including articles published since 2020. Results, associated risk factors of cognitive decline include female sex, chronic diseases, smoking, and history of hospitalization. Frequently affected cognitive domains are memory, attention, and executive function. Less commonly, language and visuospatial function is reported. Functional and structural imaging has demonstrated anatomical correlations with cognitive symptoms. Current pharmacological strategies lack enough evidence in terms of efficacy and effectiveness to design therapeutic guidelines. Cognitive rehabilitation and psychotherapy have demonstrated some benefits improving the cognitive decline and neuropsychiatric symptoms. Conclusions, characterization of post-COVID-19 syndromes definitions and clinical features is improving. However, the current level of evidence is insufficient for the development of treatment guidelines specific for cognitive decline. An interdisciplinary approach including cognitive rehabilitation, drugs, neuromodulation and other therapies could improve the outcome.

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The Revisa Médica del IMSS is considered a track of national and international scientific dissemination that presents the results of clinical research carried out within the Institute. Altmetrics, or alternative metrics, emerged as an alternative to citation-based metrics and allow authors to visualize the impact of their works that have not received citations to identify the characteristics of the readers who consult their published article. It is important that scientific journals have accurate information from their readers, as it will provide them with an overview of the use of the information produced in their area of expertise or in their institution. This editorial explores the characteristics of the readers of the Revista Médica del IMSS through the analysis of alternative metrics available in the Dimensions database.

La Revista Médica del IMSS es considerada como un medio de divulgación científica nacional e internacional que presenta los resultados de la investigación clínica realizada dentro del Instituto. Las Altmetrics, o métricas alternativas, surgieron como una alternativa a las métricas basadas en citación y permiten a los autores visibilizar el impacto de sus trabajos que no han recibido citas para identificar las características de los lectores que consultan su artículo publicado. Es importante que las revistas científicas cuenten con información precisa de sus lectores, pues les brindará un panorama sobre el uso de la información que se produce en su área de especialidad o en su institución. En este editorial se exploran las características de los lectores de la Revista Médica del IMSS a través del análisis de las métricas alternativas disponibles en la base de datos Dimensions.

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En este editorial se exploran los posibles riesgos que representa el uso de la inteligencia artificial para la elaboración de trabajos académicos y científicos. Además, se presenta una lista de riesgos para la investigación científica elaborada por la plataforma ChatGPT con el objetivo de explorar su precisión en la generación de textos.

This editorial explores the possible risks posed by the use of artificial intelligence for the preparation of academic and scientific work. Additionally, a list of risks for scientific research is presented by the ChatGPT platform with the aim of exploring its accuracy in generating texts.

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Antimicrobials are routinely used in human and veterinary medicine. With repeated exposure, antimicrobials promote antibiotic resistance, which poses a threat to public health. In this study, we aimed to determine the susceptibility patterns, virulence factors, and phylogroups of E. coli isolates during the killing process in a bovine slaughterhouse. We analyzed 336 samples (from water, surfaces, carcasses, and feces), and 83.3% (280/336) were positive for E. coli. The most common phenotypic resistances that we detected were 50.7% (142/280) for tetracycline, 44.2% (124/280) for cephalothin, 34.6% (97/280) for streptomycin, and 36.7% (103/280) for ampicillin. A total of 82.4% of the isolates had resistance for at least one antimicrobial, and 37.5% presented multiresistance. We detected a total of 69 different phenotypic resistance patterns. We detected six other resistance-related genes, the most prevalent being tetA (22.5%) and strB (15.7%). The prevalence values of the virulence genes were 5.4% in hlyA, 1.4% in stx1, and 0.7% in stx2. The frequencies of the pathogenic strains (B2 and D) were 32.8% (92/280) and 67.1% (188/280) as commensals A and B1, respectively. E. coli isolates with pathogenic potential and multiresistance may represent an important source of dissemination and a risk to consumers.

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The Revista Médica del IMSS faces the challenge of maintaining the visibility of its articles within the science communication process through indexing in bibliographic databases that make the scientific articles published available to readers, thanks to automation and constant development of information search and retrieval systems. Indexing represents the main means by which a reader will consult your articles regardless of their geographic location, their educational specialization, their affiliation, and even their native language. Likewise, it allows the generation of bibliometric indicators, which are used to evaluate scientific production.

La Revista Médica del IMSS enfrenta el reto de mantener la visibilidad de sus artículos dentro del proceso de comunicación de la ciencia a través de la indización en bases de datos bibliográficas, las cuales ponen al alcance de los lectores los artículos científicos que publica gracias a la automatización y desarrollo constante de los sistemas de búsqueda y recuperación de información. La indización representa el principal medio por el cual un lector consultará sus artículos, independientemente de su ubicación geográfica, la especialización de su formación, su afiliación e, incluso, su idioma natal. Así también, permite la generación de indicadores bibliométricos, los cuales son usados para evaluar la producción científica.

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Las intervenciones profesionales de los trabajadores sociales y los bibliotecarios durante la pandemia por COVID-19 convergieron en el empleo de las tecnologías de la información para satisfacer necesidades de información tanto de personal médico como de los pacientes y sus familias. La colaboración de estos dos profesionales reforzaría significativamente el equipo multidisciplinario de la salud a partir de la mejora de los canales de flujo de información que se llevan a cabo en el ámbito hospitalario, el fomento a la atención humanizada en salud y las acciones de inclusión social en las bibliotecas para brindar mayores y mejores oportunidades, así como recursos a población vulnerable.

The professional interventions of social workers and librarians during the COVID-19 pandemic converged in the use of information technologies to meet the information needs of both medical personnel and patients and their families. The collaboration of these two professionals would significantly strengthen the multidisciplinary health team by improving the information flow channels that are carried out in the hospital, promoting humanized health care and carrying out social inclusion actions in libraries to provide greater and better opportunities and resources for the vulnerable population.

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Psychosocial, social and structural conditions have rarely been studied among transgender women in the U.S.-Mexico Border. This study used Photovoice methodology to empower migrant transgender women of color (TWC) to reflect on realities from their own perspectives and experiences and promote critical dialogue, knowledge, and community action. Sixteen participants documented their daily experiences through photography, engaged in photo-discussions to assess needs and identify opportunities, and developed a community-informed Call to Action. Four major themes emerged from the participants' photographs, discussions, and engagement: (1) mental health, (2) migration experiences and challenges, (3) stigma, discrimination, and resiliency, and (4) impact of the COVID-19 pandemic. Through active community engagement, a Call to Action was developed. A binational advisory committee of decision makers and scholars reviewed a set of recommendations to better respond to the needs of TWC in the U.S.-Mexico Border. Photovoice served as an empowerment tool for TWC to assess the myriad of syndemic conditions, including mental health, stigma, discrimination and COVID-19, affecting them daily and identify initiatives for change.

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In the information units that make up the Instituto Mexicano del Seguro Social (IMSS) Library System, the task of guiding and training users on the use of information is a complex process, due to the specificity of the users' information needs. The information systems that are used in the Institute require the personal librarian to have specific information skills for access, evaluation, organization and use of information through information technologies. However, there are important challenges, such as the lack of definition of the professional profile of the medical librarian, because it is essential for the staff to efficiently satisfy the demands and needs of users according to their various profiles.

En las unidades de información que integran el Sistema Bibliotecario del Instituto Mexicano del Seguro Social (IMSS), la tarea de orientar y formar a los usuarios sobre el uso de información es un proceso complejo, debido a la especificidad de las necesidades de información de los usuarios. Los sistemas de información que son utilizados en el Instituto exigen al personal bibliotecario contar con competencias informativas específicas para el acceso, evaluación, organización y uso de la información por medio de las tecnologías de la información. Sin embargo, existen grandes retos, como la carencia de la definición del perfil profesional del bibliotecario médico, ya que es indispensable para que el personal logre satisfacer de forma eficiente las demandas y necesidades de los usuarios de acuerdo con sus diversos perfiles.

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En las unidades de información que integran el Sistema Bibliotecario del Instituto Mexicano del Seguro Social (IMSS), la tarea de orientar y formar a los usuarios sobre el uso de información es un proceso complejo, debido a la especificidad de las necesidades de información de los usuarios. Los sistemas de información que son utilizados en el Instituto exigen al personal bibliotecario contar con competencias informativas específicas para el acceso, evaluación, organización y uso de la información por medio de las tecnologías de la información. Sin embargo, existen grandes retos, como la carencia de la definición del perfil profesional del bibliotecario médico, ya que es indispensable para que el personal logre satisfacer de forma eficiente las demandas y necesidades de los usuarios de acuerdo con sus diversos perfiles.

In the information units that make up the Instituto Mexicano del Seguro Social (IMSS) Library System, the task of guiding and training users on the use of information is a complex process, due to the specificity of the users' information needs. The information systems that are used in the Institute require the personal librarian to have specific information skills for access, evaluation, organization and use of information through information technologies. However, there are important challenges, such as the lack of definition of the professional profile of the medical librarian, because it is essential for the staff to efficiently satisfy the demands and needs of users according to their various profiles.

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The COVID-19 pandemic caused various effects in the world, among them the saturation of information in the traditional media, as well as in those of scientific dissemination, due to the accelerated production of informative material. At the Mexican Institute for Social Security (Instituto Mexicano del Seguro Social), librarians have contributed to the careful selection of documents as they are in charge of providing specialized information services to health personnel in order to support them in academic, educational, teaching and research activities. In the context of physical distancing, the need for up-to-date and accurate information on the new coronavirus became a priority. In this sense, librarians have focused their efforts to carry out strategies that would allow to provide specialized information services remotely, reinforcing reference services such as bibliographic alert and Selective Information Dissemination, to reach users in a timely manner, simple and agile, updated, reliable and quality information on COVID-19. These services have been well received by users, but it is still necessary to systematize the provision of information services to identify which documents are of greatest interest and usefulness.

La pandemia por COVID-19 ocasionó diversas afectaciones en el mundo, entre ellas la saturación de información en los medios de comunicación tradicionales y en los de divulgación científica, debido a la producción acelerada de material informativo. En el Instituto Mexicano del Seguro Social, el personal bibliotecario ha contribuido a la selección cuidadosa de documentos, ya que brinda servicios de información especializada al personal de salud para apoyarlo en actividades académicas, educativas, docentes y de investigación. En el contexto del distanciamiento físico, la necesidad de contar con información actualizada y veraz sobre el nuevo coronavirus se convirtió en una prioridad. En este sentido, el personal bibliotecario enfocó sus esfuerzos en llevar a cabo estrategias que permitieran brindar servicios de información especializada vía remota al reforzar los servicios de referencia, como la alerta bibliográfica y la Diseminación Selectiva de Información, a fin de hacer llegar a los usuarios, de forma oportuna, sencilla y ágil, información actualizada, confiable y de calidad sobre la COVID-19. Estos servicios han sido bien recibidos por los usuarios, pero aún es necesario sistematizar el otorgamiento de servicios de información para identificar cuáles documentos son de mayor interés y utilidad.

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La pandemia por COVID-19 ocasionó diversas afectaciones en el mundo, entre ellas la saturación de información en los medios de comunicación tradicionales y en los de divulgación científica, debido a la producción acelerada de material informativo. En el Instituto Mexicano del Seguro Social, el personal bibliotecario ha contribuido a la selección cuidadosa de documentos, ya que brinda servicios de información especializada al personal de salud para apoyarlo en actividades académicas, educativas, docentes y de investigación. En el contexto del distanciamiento fìsico, la necesidad de contar con información actualizada y veraz sobre el nuevo coronavirus se convirtió en una prioridad. En este sentido, el personal bibliotecario enfocó sus esfuerzos en llevar a cabo estrategias que permitieran brindar servicios de información especializada vía remota al reforzar los servicios de referencia, como la alerta bibliográfica y la Diseminación Selectiva de Información, a fin de hacer llegar a los usuarios, de forma oportuna, sencilla y ágil, información actualizada, confiable y de calidad sobre la COVID-19. Estos servicios han sido bien recibidos por los usuarios, pero aún es necesario sistematizar el otorgamiento de servicios de información para identificar cuáles documentos son de mayor interés y utilidad.

The COVID-19 pandemic caused various effects in the world, among them the saturation of information in the traditional media, as well as in those of scientific dissemination, due to the accelerated production of informative material. At the Mexican Institute for Social Security (Instituto Mexicano del Seguro Social), librarians have contributed to the careful selection of documents as they are in charge of providing specialized information services to health personnel in order to support them in academic, educational, teaching and research activities. In the context of physical distancing, the need for up-to-date and accurate information on the new coronavirus became a priority. In this sense, librarians have focused their efforts to carry out strategies that would allow to provide specialized information services remotely, reinforcing reference services such as bibliographic alert and Selective Information Dissemination, to reach users in a timely manner, simple and agile, updated, reliable and quality information on COVID-19. These services have been well received by users, but it is still necessary to systematize the provision of information services to identify which documents are of greatest interest and usefulness.

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What is the role of keywords in a scholarly article? What are they for? Are keywords and descriptors the same? In this editorial those and other questions related to the use of keywords are answered, in order for the authors of scholarly articles to choose them properly so that they can guide their potential readers and increase the visibility of their article, which can lead to its citation.

¿Cuál es la función de las palabras clave en un artículo científico? ¿Para qué sirven? ¿Son lo mismo que los descriptores? En el presente editorial se responden esas y otras preguntas relacionadas con el uso de las palabras clave, a fin de que los autores de artículos científicos las elijan de una mejor manera para guiar a sus potenciales lectores y aumentar la visibilidad de su artículo, lo cual puede incrementar las probabilidades de que sea citado.

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¿Cuál es la función de las palabras clave en un artículo científico? ¿Para qué sirven? ¿Son lo mismo que los descriptores? En el pre- sente editorial se responden esas y otras preguntas relacionadas con el uso de las palabras clave, a fin de que los autores de artí- culos científicos las elijan de una mejor manera para guiar a sus potenciales lectores y aumentar la visibilidad de su artículo, lo cual puede incrementar las probabilidades de que sea citado.

What is the role of keywords in a scholarly article? What are they for? Are keywords and descriptors the same? In this editorial those and other questions related to the use of keywords are answered, in order for the authors of scholarly articles to choose them properly so that they can guide their potential readers and increase the visibility of their article, which can lead to its citation.

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Since determining the structure of the DNA double helix, the study of genes and genomes has revolutionized contemporary science; with the decoding of the human genome, new findings have been achieved, including the ability that humans have developed to modify genetic sequences in vitro. The discovery of gene modification mechanisms, such as the CRISPR-Cas system (Clustered Regularly Interspaced Short Palindromic Repeats) and Cas (CRISPR associated). Derived from the latest discoveries in genetics, the idea that science has no limits has exploded. However, improvements in genetic engineering allowed access to new possibilities to save lives or generate new treatment options for diseases that are not treatable by using genes and their modification in the genome. With this greater knowledge, the immediate question is who governs the limits of genetic science? The first answer would be the intervention of a legislative branch, with adequate scientific advice, from which the logical answer, bioethics, should result. This term was introduced for the first time by Van Rensselaer Potter, who in 1970 combined the Greek words bios and ethos, Bio-Ethik, which determined the study of the morality of human behavior in science. The approach to this term was introduced to avoid the natural tension that results from the scientific technical development and the ethics of limits. Therefore, associating the use of biotechnology through the CRISPR-Cas system and the regulation through bioethics, aims to monitor the use of techniques and technology, with benefits for humanity, without altering fundamental rights, acting with moral and ethical principles.