RESUMEN
Extracts from several plants of the family Bignoniaceae from Panama were submitted to a rapid DPPH TLC test for the detection of radical-scavenging activity. The MeOH extract of the stems of Jacaranda caucana, a tree that grows from Costa Rica to Colombia, was selected due to its interesting activity and the lack of phytochemical studies on the polar extract. This extract was partitioned between ethyl acetate, butanol, and water. The EtOAc fraction afforded two new phenylethanoid glycosides (1, 2), along with protocatechuic acid, acteoside, and jionoside D. Further purifications yielded isoacteoside and martynoside. The BuOH fraction afforded a new rhamnosyl derivative of sisymbrifolin (8), a neolignan. The structures were determined by means of spectrometric methods, including 1D and 2D NMR experiments and MS analysis.
Asunto(s)
Antioxidantes/aislamiento & purificación , Antioxidantes/farmacología , Bignoniaceae/química , Depuradores de Radicales Libres/aislamiento & purificación , Depuradores de Radicales Libres/farmacología , Glucósidos/aislamiento & purificación , Glucósidos/farmacología , Glicósidos/aislamiento & purificación , Glicósidos/farmacología , Lignanos/aislamiento & purificación , Lignanos/farmacología , Fenoles/aislamiento & purificación , Fenoles/farmacología , Plantas Medicinales/química , Antioxidantes/química , Depuradores de Radicales Libres/química , Glucósidos/química , Glicósidos/química , Lignanos/química , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Panamá , Fenoles/química , Tallos de la Planta/químicaRESUMEN
Chemical investigation of the methanol extract from the leaves of Arrabidaea patellifera, a Bignoniaceae from Panama, afforded mangiferin, isomangiferin, and six new derivatives (3'-O-p-hydroxybenzoylmangiferin, 3'-O-trans-coumaroylmangiferin, 6'-O-trans-coumaroylmangiferin, 3'-O-trans-cinnamoylmangiferin, 3'-O-trans-caffeoylmangiferin, and 3'-O-benzoylmangiferin). All these compounds had antioxidant and radical-scavenging activities, and four of them were relatively active in vitro against Plasmodium falciparum. The structures were determined by spectrometric and chemical methods, including 1D and 2D NMR experiments and MS analysis.