RESUMEN

Alzheimer's disease is a neurodegenerative pathology whose pathognomonic hallmarks are increased generation of ß-amyloid (Aß) peptide, production of hyperphosphorylated (pTau), and neuroinflammation. The last is an alteration closely related to the progression of AD and although it is present in multiple neurodegenerative diseases, the pathophysiological events that characterize neuroinflammatory processes vary depending on the disease. In this article, we focus on mRNA and non-coding RNA alterations as part of the pathophysiological events characteristic of neuroinflammation in AD and the influence of these alterations on the course of the disease through interaction with multiple RNAs related to the generation of Aß, pTau, and neuroinflammation itself.

Asunto(s)

Enfermedad de Alzheimer , Enfermedades Neuroinflamatorias , ARN Mensajero , ARN no Traducido , Enfermedad de Alzheimer/genética , Enfermedad de Alzheimer/patología , Enfermedad de Alzheimer/metabolismo , Humanos , ARN Mensajero/metabolismo , ARN Mensajero/genética , ARN no Traducido/genética , ARN no Traducido/metabolismo , Animales , Enfermedades Neuroinflamatorias/metabolismo , Enfermedades Neuroinflamatorias/genética , Péptidos beta-Amiloides/metabolismo , Inflamación/genética , Inflamación/patología