RESUMEN
In humans, most clinical variables follow biological rhythms approaching to a mathematical function defined by the cosmic-climatic rhythm. Chronophysiology, chronopathology, chronopharmacology, chronotherapy and phototherapy have common elements frequently studied in a disperse manner, thus making it difficult a global understanding of clinical chronobiology as a unitary and well-characterized discipline. This review focuses on medical chronobiology, which is much more technical since it only gathers those directives of clinical chronobiology having a health-care impact on daily practice.
Asunto(s)
Trastornos Cronobiológicos/terapia , Fenómenos Cronobiológicos/fisiología , Cronoterapia/métodos , Enfermedad Aguda , Enfermedad Crónica , Ensayos Clínicos como Asunto , HumanosRESUMEN
El paracetamol figura entre los fármacos más comunes de la Atención Farmacéutica. En los últimos años las autoridades sanitarias de varios países occidentales han advertido de los riesgos del paracetamol asociados a un uso inadecuado, así como de la gravedad de las intoxicaciones por paracetamol. En Gran Bretaña, en 1998, se legislaron unas medidas restrictivas para evitar el fácil acceso y racionalizar su uso. Publicaciones recientes han valorado tales medidas como muy positivas. Esta revisión pretende revisar el problema del uso indiscriminado del fármaco en cuestión en nuestro país y el papel de la Atención Farmacéutica en el manejo racional desde una perspectiva objetiva, sustentada por la evidencia científica (AU)
Paracetamol is one of the most common drugs of the Pharmaceutical care. In the last years health authorities in several western countries warned about the risks of paracetamol associated to an inadequate use, as well as about the severity of paracetamol poisoning. In Great Britain, in 1998, restrictive measures were legislated to avoid the easy access and to rationalize their use. Recent publications have evaluated such measures very positively. This revision tries to review the problem of the indiscriminate use of this compound, in our country and, the role of the Pharmaceutical Care in the rational management from an evidence based perspective (AU)