RESUMEN

Three new cytotoxic 3,6-disubstituted indoles (1-3) were isolated from the mycelium of a strain identified as Streptomyces sp. (BL-49-58-005), which was separated from a Mexican marine invertebrate, and their structures established by analysis of NMR and mass spectral data. GI(50) values for 1 and 2 in cytotoxic bioassays against a panel of 14 different tumor cell lines were estimated at micromolar range, while compound 3 showed no activity in the same assays.

Asunto(s)

Antineoplásicos/aislamiento & purificación , Indoles/aislamiento & purificación , Streptomyces/química , Antineoplásicos/química , Antineoplásicos/farmacología , Línea Celular Tumoral/efectos de los fármacos , Neoplasias del Colon , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Indoles/química , Indoles/farmacología , Concentración 50 Inhibidora , Leucemia , Masculino , México , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Neoplasias Pancreáticas , Neoplasias de la Próstata