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Rev Biol Trop ; 39(2): 311-4, 1991 Nov.
Artículo en Español | MEDLINE | ID: mdl-1844159

RESUMEN

Hemolytic activity of eight Peruvian snake venoms from the families Viperidae and Elapidae (Bothrops atrox, B. pictus, B. hyoprorus, B. bilineatus, B. neuwedii, Lachesis m. muta, Crotalus d. terrificus, Micrurus tschudi), and three Brazilian viperids (B. jararacussu, B. alternatus and C. d. collilineatus) is described. None of the venoms caused direct lysis on washed human erythrocytes. However, all of them caused indirect hemolysis provided that the incubation medium contains an exogenous source of lecithin. Venom of Micrurus tschudi was the most hemolytic (HD50 2.8 ug/ml) while that of B. bilineatus was the least (HD50 681.3 ug/ml). Only six of eleven venoms showed parallel curves of hemolytic activity, and the HD50 varied from 198 to 681 ug/ml and the following decreasing order of hemolytic activity was obtained: L. muta, C. d. terrificus, C. d. collilineatus, B. hyoprorus, B. bilineatus, B. alternatus.


Asunto(s)
Venenos Elapídicos/farmacología , Hemólisis , Venenos de Víboras/farmacología , Animales , Proteínas Cardiotóxicas de Elápidos/farmacología , Humanos , Fosfolipasas A/farmacología , Análisis de Regresión
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