RESUMEN
Leukoencephalomyelopathy is a nonspecific lesion characterized by widespread vacuolation of central nervous system white matter. It is mainly of genetic basis, occurring in young pure breed dogs. This report describes a neurodegenerative disease associated to demyelination in an adult mixed breed female dog. After 20 days in a kennel with12 other dogs, the dog showed progressive nervous signs with ataxia and inability to maintain balance. No other dog was affected. After 15 days, the animal was euthanized in extremis and necropsied. No macroscopic lesions of diagnostic relevance were present. Microscopically, status espongiosus was observed in white matter throughout the length of theneuroaxis, from frontal brain lobe to lumbar spinal cord. Specific stains of Kluver Barrera and immunohistochemistry for the detection of phosphorylated and non-phosphorylated neurofilaments, microglia, astrocytosis, oligodendrocytosis and myelin proteins in brain and spinal cord sections showed demyelination, axonal fragmentation and degeneration, microgliosis and decrease of oligodendrocytes. The anatomopathological study and epidemiological data suggests a primary demyelination due to decrease in number and function of oligodendrocytes, which is probably of genetic basis with lateonset.
Asunto(s)
Femenino , Animales , Perros , Enfermedades Desmielinizantes del Sistema Nervioso Central Hereditarias , Enfermedades Desmielinizantes del Sistema Nervioso Central Hereditarias , Enfermedades de los Perros/etiología , Médula Espinal/patologíaRESUMEN
Leukoencephalomyelopathy is a nonspecific lesion characterized by widespread vacuolation of central nervous system white matter. It is mainly of genetic basis, occurring in young pure breed dogs. This report describes a neurodegenerative disease associated to demyelination in an adult mixed breed female dog. After 20 days in a kennel with12 other dogs, the dog showed progressive nervous signs with ataxia and inability to maintain balance. No other dog was affected. After 15 days, the animal was euthanized in extremis and necropsied. No macroscopic lesions of diagnostic relevance were present. Microscopically, status espongiosus was observed in white matter throughout the length of theneuroaxis, from frontal brain lobe to lumbar spinal cord. Specific stains of Kluver Barrera and immunohistochemistry for the detection of phosphorylated and non-phosphorylated neurofilaments, microglia, astrocytosis, oligodendrocytosis and myelin proteins in brain and spinal cord sections showed demyelination, axonal fragmentation and degeneration, microgliosis and decrease of oligodendrocytes. The anatomopathological study and epidemiological data suggests a primary demyelination due to decrease in number and function of oligodendrocytes, which is probably of genetic basis with lateonset.(AU)
Asunto(s)
Animales , Femenino , Perros , Enfermedades Desmielinizantes del Sistema Nervioso Central Hereditarias/patología , Enfermedades Desmielinizantes del Sistema Nervioso Central Hereditarias/veterinaria , Enfermedades de los Perros/etiología , Médula Espinal/patologíaRESUMEN
Urgent endoscopic retrograde cholangiopancreatography in acute pancreatitis allows to detect associated biliary disease, display the bilio-pancreatic anatomy to plan optional early surgery and offer an alternative in the treatment with endoscopic sphincterotomy and/or infundibulotomy, in cases of choledocholithiasis and impacted stone at the ampulla of Vater. In relation to the prevalence of biliary lesions in the etiology of acute pancreatitis, the urgent ERCP is a safe and useful procedure that offer diagnosis and treatment, so therefore, it must be considered during the evaluation of patients with acute pancreatitis.