RESUMEN
Gorlin's syndrome is a relatively rare generalized disorder. Its diagnosis in childhood is usually through oral abnormalities. Some of the most frequent clinical features of this syndrome are discovered through radiographs commonly used in orthodontia. Thus, the orthodontist may be able to contribute to its diagnosis. The article shows three clinical cases that illustrate the role that the orthodontist may play in diagnosis of this syndrome.
Asunto(s)
Síndrome del Nevo Basocelular/diagnóstico , Neoplasias Maxilomandibulares/diagnóstico , Ortodoncia , Síndrome del Nevo Basocelular/complicaciones , Síndrome del Nevo Basocelular/patología , Niño , Femenino , Humanos , Anomalías Maxilomandibulares/etiología , Quistes Maxilomandibulares/diagnóstico por imagen , Quistes Maxilomandibulares/etiología , Masculino , Radiografía PanorámicaRESUMEN
Popular customs with regard to tooth replacement are closely linked to magical ideas. The most important ones--such as throwing the tooth on the roof, giving it to mice or hiding it in different places--occur in places which are very far distant from one another, indicating that these customs originate from ancestral cultures.
Asunto(s)
Atención Dental para Niños/psicología , Folclore , Exfoliación Dental/psicología , Animales , Niño , Preescolar , Humanos , Magia , Ratones , Diente PrimarioRESUMEN
In primary cultures of mouse Leydig cells, testosterone represses the cAMP-induced de novo synthesis of P450 17 alpha-hydroxylase/C17-20 lyase (P450c17) protein and the accumulation of P450c17 mRNA, via an androgen receptor (AR)-mediated mechanism. To examine the mechanism by which androgens repress the cAMP-induced expression of the mouse Cyp17 gene, constructs containing 5'-flanking sequences of the mouse Cyp17 linked to the chloramphenicol acetyltransferase (CAT) reporter gene were cotransfected into MA-10 tumor Leydig cells with a mouse AR expression plasmid. In the presence of dihydrotestosterone, the cAMP-induced expression of a reporter construct containing -1021 bp of Cyp17 promoter sequences was repressed. In contrast, no repression by dihydrotestosterone was observed when the -1021 bp Cyp17-CAT construct was cotransfected with a human AR expression plasmid missing the second zinc finger of the DNA-binding domain, indicating that DNA binding is involved in AR-mediated repression of Cyp17 expression. Analysis of deletions -346 bp of 5'-flanking region of the mouse Cyp17 promoter are sufficient to confer androgen repression of the cAMP-induced expression of Cyp17. Deoxyribonuclease I footprinting analysis indicated that the AR interacts with sequences between -330. and -278 bp of the Cyp17 promoter. This region overlaps with the previously identified cAMP-responsive region located between -346 and -245 bp of the Cyp17 promoter. These results suggest that AR-mediated repression involves binding of the AR to sequences in the cAMP-responsive region of the Cyp17 promoter, possibly interfering with the binding of the protein(s) that mediate cAMP induction of Cyp17.