RESUMEN

In areas where the zoonotic disease leptospirosis is endemic, reduced morbidity and mortality is strongly linked to quick initiation of renal replacement therapy.

RESUMEN

Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel syndrome (SCS). A multivariate analysis using running wheels was used to generate activity profiles for a variety of SCS models, uncovering unique locomotor patterns for the different nAChR mutants. Particularly, the αL251T and ɛL269F mutations exhibit decreased event distance, duration, and velocity over a period of 24 hours. Our approach suggests a robust relationship between the pathophysiology of SCS and locomotor activity.

Asunto(s)

Locomoción/genética , Locomoción/fisiología , Mutación , Receptores Nicotínicos/genética , Receptores Nicotínicos/metabolismo , Animales , Modelos Animales de Enfermedad , Análisis de la Marcha , Masculino , Ratones Endogámicos C57BL , Ratones Transgénicos , Trastornos del Movimiento/genética , Trastornos del Movimiento/metabolismo , Análisis Multivariante , Fenotipo , Especificidad de la Especie , Síndrome , Volición