RESUMEN
Two cases are described of infants in whom paroxysmal supraventricular tachycardia was the first clinical manifestation of an underlaying dilatating cardiomyopathy. To stop the tachycardia in such cases drugs without inotropic negative effect are recommended.
Asunto(s)
Cardiomiopatía Dilatada/diagnóstico , Taquicardia Paroxística/etiología , Amiodarona/uso terapéutico , Bloqueo de Rama/etiología , Cardiomiopatía Dilatada/complicaciones , Glicósidos Digitálicos/uso terapéutico , Femenino , Humanos , Lactante , Taquicardia Paroxística/tratamiento farmacológicoRESUMEN
The case histories of two children (aged two months) affected by myocarditis showing an atypical band of serum creatine kinase (EC 2.7.3.2; CK) in the CK isoenzyme electrophoretic pattern are reported. The electrophoretic mobility on cellulose acetate of the atypical iso-CK band and its greater relative molecular mass, the lack of binding with immunoglobulins and the result of CK-BB determination by RIA, allowed us to identify the band with an oligomeric form of the mitochondrial isoenzyme. One child died 2 days after admission, while in the other it was possible to demonstrate reduction and disappearance of the atypical band in concomitance with a marked clinical improvement. Our findings suggest that the oligomeric form of mitochondrial-CK is released in conditions of serious heart muscle damage, and that it may be an indicator of myocardial cellular necrosis in pediatric patients.
Asunto(s)
Creatina Quinasa/sangre , Miocarditis/diagnóstico , Pruebas Enzimáticas Clínicas , Femenino , Humanos , Inmunoglobulinas/análisis , Lactante , Isoenzimas , Masculino , Miocarditis/sangre , Miocarditis/inmunología , Valores de ReferenciaRESUMEN
Feces samples of 35 children, aged between 3 and 24 months (mean age 12 months), were analyzed. Sixteen children who had no therapy were considered as "control samples"; an antibiotic therapy was administered to 8 subjects for at least 5 days for extraintestinal pathology (ampicillin, orally, at a dose of 100 mg/kg/die in three doses). Finally, the same antibiotic therapy with the addition, from the beginning over 5 days, of the oral preparation of Bacillus subtilis spores (4 X 10(9) die) was administered to 11 patients. During antibiotic therapy, the number of stools per day increased, but not for those patients taking B. subtilis spores. Regarding the bacterial flora, the subjects treated with antibiotic therapy alone showed a significant decrease of all aerobic species, except for fungi, anaerobic total count and aerobic cocci. After oral bacteriotherapy together with ampicillin, we observed an increase of saccharolytic flora, aerobic and anaerobic, while proteolytic flora did not show any changes.