RESUMEN
The use of n-3 polyunsaturated fatty acids in surgical patients has risen by the fact that this may attenuate systemic and acute inflammatory responses secondary to surgical trauma through modulation of inflammatory mediators and cell membrane interactions. Moreover, the inclusion of n-3 fatty acids in clinical trials as part of the therapy in patients, who expect to undergo a surgical stress, suggests benefits on clinical progress. Therefore, the objective of this article is to review data from n-3 polyunsaturated fatty acid effects on biochemical parameters and on reduced length of hospitalization, number of infections, and mortality as main clinical outcomes in human surgical patients.
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Ácidos Grasos Insaturados/uso terapéutico , Complicaciones Posoperatorias/tratamiento farmacológico , Estrés Fisiológico/efectos de los fármacos , Procedimientos Quirúrgicos Operativos , Hospitalización , Humanos , Mediadores de Inflamación/metabolismo , Complicaciones Posoperatorias/metabolismo , Complicaciones Posoperatorias/mortalidad , Síndrome de Respuesta Inflamatoria Sistémica/tratamiento farmacológico , Síndrome de Respuesta Inflamatoria Sistémica/metabolismo , Síndrome de Respuesta Inflamatoria Sistémica/mortalidadRESUMEN
Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimate quantitatively the current state of the knowledge concerning the neuroprotective effect of drugs inhibiting glutamate release and to attempt to resolve the apparent controversy in relation to the neuroprotective properties of these drugs, a meta-analysis was performed. It identified a significant difference between drugs blocking glutamate release and controls. Therefore, we hypothesize that inhibition of presynaptic glutamate release could be a major goal in neuroprotection when ischemic brain damage is present and that meta-analysia could be a useful tool for preclinical studies,
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Isquemia Encefálica/metabolismo , Ácido Glutámico/metabolismo , Fármacos Neuroprotectores/farmacología , Sinapsis/efectos de los fármacos , Humanos , Metaanálisis como AsuntoRESUMEN
BACKGROUND: Experimental undernutrition in animals, during the critical brain development period, produces retardation of brain growth as well as a number of different morphologic and functional abnormalities in neurons, mainly in the dendritic synaptic apparatus. These alterations are the cause of the poor neurointegrative development that occurs in experimental malnutrition. Severe malnutrition during early postnatal life in humans is known to produce similar neurointegrative disorders as well as mental retardation, but there are very few studies describing the morphology of the dendritic apparatus in infants suffering from this condition. OBJECTIVE: To study the dendritic spine density and morphology in dendrites from cortical neurons in infants dying from severe malnutrition. METHODOLOGY: Brain sections from the somestesic, motor, and occipital cortical areas of 13 infants who died of severe malnutrition and 7 eutrophic infants who died of other causes were studied by means of the rapid Golgi method. Apical dendritic spines from neurons of the fifth cortical layer were studied and counted in all sections. RESULTS: Apical dendrites were significantly shorter in malnourished infants than in the control group (581.54 +/- 54.32 microm in severe malnutrition vs 846.3 microm in normal infants). The number of dendritic spines per dendrite was also significantly diminished (185.3 +/- 36.1 in malnourished vs 374.3 +/- 41.6 in eutrophic infants). There were marked morphologic abnormalities in the dendritic spines of infants dying of severe malnutrition that were classified as dysplastic. CONCLUSIONS: Short apical dendrites, fewer spines, and dendritic spine abnormalities occur in severe infant malnutrition. These anatomic anomalies might be related to the neuropsychological deficits that occur in these children.
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Corteza Cerebral/patología , Dendritas/patología , Desnutrición Proteico-Calórica/patología , Estudios de Casos y Controles , Corteza Cerebral/citología , Preescolar , Femenino , Humanos , Lactante , MasculinoRESUMEN
Rheumatic heart disease is common in the undeveloped world; Chagas disease, a typical rural parasitic condition started to affect urban areas. Both have a relatively high incidence and prevalence in Latin America, however, we could not find a report of patients with coincidental rheumatic heart disease and Chagas disease. Herein we report the first documented case.
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Cardiomiopatía Chagásica/diagnóstico , Cardiopatía Reumática/diagnóstico , Adulto , Estenosis de la Válvula Aórtica/diagnóstico , Estenosis de la Válvula Aórtica/patología , Estenosis de la Válvula Aórtica/cirugía , Cardiomiopatía Chagásica/patología , Cardiomiopatía Chagásica/cirugía , Resultado Fatal , Insuficiencia Cardíaca/diagnóstico , Insuficiencia Cardíaca/patología , Insuficiencia Cardíaca/cirugía , Humanos , Masculino , Estenosis de la Válvula Mitral/diagnóstico , Estenosis de la Válvula Mitral/patología , Estenosis de la Válvula Mitral/cirugía , Miocardio/patología , Cardiopatía Reumática/patología , Cardiopatía Reumática/cirugíaAsunto(s)
Encéfalo/metabolismo , Ácido gamma-Aminobutírico/fisiología , Canales de Calcio/fisiología , Cloruros/metabolismo , Canales Iónicos/efectos de los fármacos , Canales Iónicos/fisiología , Potenciales de la Membrana , Fármacos Neuroprotectores/farmacología , Progesterona/metabolismo , Receptores de GABA-A/efectos de los fármacos , Receptores de GABA-A/metabolismo , Receptores de GABA-B/efectos de los fármacos , Receptores de GABA-B/metabolismo , Sodio/metabolismo , Agua/metabolismoRESUMEN
INTRODUCTION AND OBJECTIVES: Personal contact has been lost in medical training due to the increase in numbers of medical students but not of teachers. This fact has impaired training in medical specialties. This is the reason that the Hospital for Cardiology has developed a program of tutelary training. In this paper we present our initial evaluation of this program. METHODS: The inclusive criteria for tutors and students have been defined as have the procedures to develop the program. After three months, 20 residents involved in the tutelary training program were randomly analyzed. Academic activities, clinical practice, research activities and extra-academic activities were evaluated. RESULTS: Currently there are 14 tutors. 50% of residents have developed research projects, 60% has increased academic activities, 50% has improved clinical practice and 65% has defined their postgraduate research projects. CONCLUSIONS: It was concluded that tutelary training in Cardiology and Cardiothoracic Surgery is a useful alternative to improve quality of graduates in these specialties.