RESUMEN
The study was carried out on twenty nine geriatric patients with malnutrition of variable aetiology. The effectiveness of a temporary parenteral nutritional supplement was evaluated both clinically and by means of some metabolic indexes: nitrogen balance, serum albumin, blood electrolytes, acid-base parameters, hemocytometry. The treatment was devoid of metabolic complications, and promoted a positive nitrogen balance as well as clinical improvement in most patients.
Asunto(s)
Trastornos Nutricionales/dietoterapia , Nutrición Parenteral Total , Anciano , Anciano de 80 o más Años , Peso Corporal , Estudios de Evaluación como Asunto , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Trastornos Nutricionales/etiología , Trastornos Nutricionales/metabolismo , Factores de TiempoRESUMEN
The age effect on the kinetics of piroxicam at the steady-state after oral administration of piroxicam beta-cyclodextrin was evaluated. The mean plasma concentration of piroxicam at the steady-state was significantly higher in elderly subjects (9.30 +/- 0.69 micrograms/ml mean +/- s.e.) than in younger adults (6.24 +/- 0.58 micrograms/ml mean +/- s.e.). Even though the distribution volume tended to be lower in elderly subjects (106.37 ml/kg), it did not show substantial differences in the two groups whereas the correlation between clearance and age was significant (p less than 0.05). It is therefore confirmed that piroxicam beta-cyclodextrin has the same pharmacokinetic behaviour at the steady-state in elderly subjects, as the active principle in a non-complexed form.