RESUMEN
Complexes of Zn2+ with deprotonated suphonylurea as ligands have been synthesized and characterized. Deprotonated sulphonylurea act as bidentate ligands using one nitrogen and one oxygen atom (the ureido oxygen) to bind Zn2+ forming K[Zn(suphonylurea)3]. Using the MMX89 program, a model for K[Zn(ClC6H4SO2NCONHC3H7)3] compound is proposed. Conductometric and potentiometric studies in methanol, for d10 metal-sulphonylurea complexes, demonstrated that zinc, cadmium and silver complexes are 1:1 electrolytes and are protonated in the range 4.2-5.6 pH. UV-Vis study shows no interaction between metal and protonated sulphonylureas in methanol solutions. At 7.34 pH the form of Zn complexes which act as a hypoglycemic agent is [ZnL3]-. Test for hypoglycemic activity reduced glycemia to a statistically significant degree compared to the corresponding free ligands.