RESUMEN
Growth-restricted fetuses are at risk of hypoxemia, acidemia, and stillbirth because of progressive placental dysfunction. Current fetal well-being, neonatal risks following delivery, and the anticipated rate of fetal deterioration are the major management considerations in fetal growth restriction. Surveillance has to quantify the fetal risks accurately to determine the delivery threshold and identify the testing frequency most likely to capture future deterioration and prevent stillbirth. From the second trimester onward, the biophysical profile score correlates over 90% with the current fetal pH, and a normal score predicts a pH >7.25 with a 100% positive predictive value; an abnormal score on the other hand predicts current fetal acidemia with similar certainty. Between 30% and 70% of growth-restricted fetuses with a nonreactive heart rate require biophysical profile scoring to verify fetal well-being, and an abnormal score in 8% to 27% identifies the need for delivery, which is not suspected by Doppler findings. Future fetal well-being is not predicted by the biophysical profile score, which emphasizes the importance of umbilical artery Doppler and amniotic fluid volume to determine surveillance frequency. Studies with integrated surveillance strategies that combine frequent heart rate monitoring with biophysical profile scoring and Doppler report better outcomes and stillbirth rates of between 0% and 4%, compared with those between 8% and 11% with empirically determined surveillance frequency. The variations in clinical behavior and management challenges across gestational age are better addressed when biophysical profile scoring is integrated into the surveillance of fetal growth restriction. This review aims to provide guidance on biophysical profile scoring in the in- and outpatient management of fetal growth restriction.
Asunto(s)
Retardo del Crecimiento Fetal , Placenta , Líquido Amniótico , Femenino , Retardo del Crecimiento Fetal/diagnóstico por imagen , Humanos , Recién Nacido , Embarazo , Ultrasonografía , Arterias Umbilicales/diagnóstico por imagenRESUMEN
PURPOSE OF REVIEW: Recognition of the fetus at risk for death or damage in utero, quantifying the risk, balancing fetal risk against the risk of neonatal complications from immaturity and determining optimal time and mode of intervention, is a cornerstone of modern perinatal medicine. Antepartum fetal testing is essential in making these crucial decisions. The art and science of fetal assessment is fluid. In this treatise, the evolution of testing is reviewed, test accuracy results examined and suggestions for future applications are considered. RECENT FINDINGS: Composite testing of a range of fetal biophysical variables is an excellent predictor of fetal acidemia and risk of death or damage. Confusion regarding the optimal means of measuring one of these variables, amniotic fluid volume, has been addressed in the literature and contemporary studies from several independent sources indicate that the amniotic fluid index method should be abandoned in favor of the maximal vertical pocket method. It is becoming increasingly more evident that a spectrum of fetal testing modalities based on interrogation of different aspects of fetal adaptive responses to adversity is preferable in fetal testing. Further it is evident that in some fetal diseases, such as intrauterine growth restriction, fetal condition may change acutely and accordingly best outcome is achieved by much more frequent testing. The question of whether intervention for fetal compromise can prevent subsequent neurological sequelae remains open. SUMMARY: There has been remarkable advancement in identifying the fetus at risk. The concept of multispectral combined fetal testing including acute biophysical variables, amniotic fluid volume and arterial and venous Doppler flow velocity waveforms is established.
Asunto(s)
Monitoreo Fetal/métodos , Atención Perinatal , Diagnóstico Prenatal/métodos , Líquido Amniótico/fisiología , Arterias/fisiología , Fenómenos Biofísicos , Velocidad del Flujo Sanguíneo , Femenino , Sufrimiento Fetal/diagnóstico , Hipoxia Fetal/diagnóstico , Feto/irrigación sanguínea , Humanos , Embarazo , Medición de Riesgo , Factores de Riesgo , Ultrasonografía Doppler , Ultrasonografía Prenatal , Venas/fisiologíaRESUMEN
BACKGROUND: Haemophilus influenzae is a rare cause of intrauterine infection, with the potential to cause severe morbidity and mortality in the perinate. CASE: An 18-year-old primigravida presented at 32 weeks' gestation with sudden-onset abdominal pain and abrupt cessation of fetal movements. Intrauterine fetal death was confirmed. At necropsy the fetus had multiorgan hemorrhage. H influenzae was cultured from the amniotic membranes and ear canal fluid. The mother was readmitted on postpartum day 2 with fever. Her blood cultures were also positive for H influenzae. CONCLUSION: H influenzae may cause ascending fetal infection and death and may cause maternal sepsis by fetomaternal transmission.