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Background: Breast cancer is a highly predominant destructive disease among women characterised with varied tumour biology, molecular subgroups and diverse clinicopathological specifications. The potentiality of machine learning to transform complex medical data into meaningful knowledge has led to its application in breast cancer detection and prognostic evaluation. Objective: The emergence of data-driven diagnostic model for assisting clinicians in diagnostic decision making has gained an increasing curiosity in breast cancer identification and analysis. This motivated us to develop a breast cancer data-driven model for subtype classification more accurately. Method: In this article, we proposed a firefly-support vector machine (SVM) breast cancer predictive model that uses clinicopathological and demographic data gathered from various tertiary care cancer hospitals or oncological centres to distinguish between patients with triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (non-TNBC). Results: The results of the firefly-support vector machine (firefly-SVM) predictive model were distinguished from the traditional grid search-support vector machine (Grid-SVM) model, particle swarm optimisation-support vector machine (PSO-SVM) and genetic algorithm-support vector machine (GA-SVM) hybrid models through hyperparameter tuning. The findings show that the recommended firefly-SVM classification model outperformed other existing models in terms of prediction accuracy (93.4%, 86.6%, 69.6%) for automated SVM parameter selection. The effectiveness of the prediction model was also evaluated using well-known metrics, such as the F1-score, mean square error, area under the ROC curve, logarithmic loss and precision-recall curve. Conclusion: Firefly-SVM predictive model may be treated as an alternate tool for breast cancer subgroup classification that would benefit the clinicians for managing the patient with proper treatment and diagnostic outcome.
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A global pandemic scenario is witnessed worldwide owing to the menace of the rapid outbreak of the deadly COVID-19 virus. To save mankind from this apocalyptic onslaught, it is essential to curb the fast spreading of this dreadful virus. Moreover, the absence of specialized drugs has made the scenario even more badly and thus an early-stage adoption of necessary precautionary measures would provide requisite supportive treatment for its prevention. The prime objective of this article is to use radiological images as a tool to help in early diagnosis. The interval type 2 fuzzy clustering is blended with the concept of superpixels, and metaheuristics to efficiently segment the radiological images. Despite noise sensitivity of watershed-based approach, it is adopted for superpixel computation owing to its simplicity where the noise problem is handled by the important edge information of the gradient image is preserved with the help of morphological opening and closing based reconstruction operations. The traditional objective function of the fuzzy c-means clustering algorithm is modified to incorporate the spatial information from the neighboring superpixel-based local window. The computational overhead associated with the processing of a huge amount of spatial information is reduced by incorporating the concept of superpixels and the optimal clusters are determined by a modified version of the flower pollination algorithm. Although the proposed approach performs well but should not be considered as an alternative to gold standard detection tests of COVID-19. Experimental results are found to be promising enough to deploy this approach for real-life applications.
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BACKGROUND: Breast cancer is the most prevailing heterogeneous disease among females characterized with distinct molecular subtypes and varied clinicopathological features. With the emergence of various artificial intelligence techniques especially machine learning, the breast cancer research has attained new heights in cancer detection and prognosis. OBJECTIVE: Recent development in computer driven diagnostic system has enabled the clinicians to improve the accuracy in detecting various types of breast tumors. Our study is to develop a computer driven diagnostic system which will enable the clinicians to improve the accuracy in detecting various types of breast tumors. METHODS: In this article, we proposed a breast cancer classification model based on the hybridization of machine learning approaches for classifying triple-negative breast cancer and non-triple negative breast cancer patients with clinicopathological features collected from multiple tertiary care hospitals/centers. RESULTS: The results of genetic algorithm and support vector machine (GA-SVM) hybrid model was compared with classics feature selection SVM hybrid models like support vector machine-recursive feature elimination (SVM-RFE), LASSO-SVM, Grid-SVM, and linear SVM. The classification results obtained from GA-SVM hybrid model outperformed the other compared models when applied on two distinct hospital-based datasets of patients investigated with breast cancer in North West of African subcontinent. To validate the predictive model accuracy, 10-fold cross-validation method was applied on all models with the same multicentered datasets. The model performance was evaluated with well-known metrics like mean squared error, logarithmic loss, F1-score, area under the ROC curve, and the precision-recall curve. CONCLUSION: The hybrid machine learning model can be employed for breast cancer subtypes classification that could help the medical practitioners in better treatment planning and disease outcome.
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Neoplasias de la Mama , Femenino , Humanos , Inteligencia Artificial , Aprendizaje Automático , Máquina de Vectores de Soporte , AlgoritmosRESUMEN
COVID-19 causes an ongoing worldwide pandemic situation. The non-discovery of specialized drugs and/or any other kind of medicines makes the situation worse. Early diagnosis of this disease will be certainly helpful to start the treatment early and also to bring down the dire spread of this highly infectious virus. This article describes the proposed novel unsupervised segmentation method to segment the radiological image samples of the chest area that are accumulated from the COVID-19 infected patients. The proposed approach is helpful for physicians, medical technologists, and other related experts in the quick and early diagnosis of COVID-19 infection. The proposed approach will be the SUFEMO (SUperpixel based Fuzzy Electromagnetism-like Optimization). This approach is developed depending on some well-known theories like the Electromagnetism-like optimization algorithm, the type-2 fuzzy logic, and the superpixels. The proposed approach brings down the processing burden that is required to deal with a considerably large amount of spatial information by assimilating the notion of the superpixel. In this work, the EMO approach is modified by utilizing the type 2 fuzzy framework. The EMO approach updates the cluster centers without using the cluster center updation equation. This approach is independent of the choice of the initial cluster centers. To decrease the related computational overhead of handling a lot of spatial data, a novel superpixel-based approach is proposed in which the noise-sensitiveness of the watershed-based superpixel formation approach is dealt with by computing the nearby minima from the gradient image. Also, to take advantage of the superpixels, the fuzzy objective function is modified. The proposed approach was evaluated using both qualitatively and quantitatively using 310 chest CT scan images that are gathered from various sources. Four standard cluster validity indices are taken into consideration to quantify the results. It is observed that the proposed approach gives better performance compared to some of the state-of-the-art approaches in terms of both qualitative and quantitative outcomes. On average, the proposed approach attains Davies-Bouldin index value of 1.812008792, Xie-Beni index value of 1.683281, Dunn index value 2.588595748, and ß index value 3.142069236 for 5 clusters. Apart from this, the proposed approach is also found to be superior with regard to the rate of convergence. Rigorous experiments prove the effectiveness of the proposed approach and establish the real-life applicability of the proposed method for the initial filtering of the COVID-19 patients.
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Due to the absence of any specialized drugs, the novel coronavirus disease 2019 or COVID-19 is one of the biggest threats to mankind Although the RT-PCR test is the gold standard to confirm the presence of this virus, some radiological investigations find some important features from the CT scans of the chest region, which are helpful to identify the suspected COVID-19 patients. This article proposes a novel fuzzy superpixel-based unsupervised clustering approach that can be useful to automatically process the CT scan images without any manual annotation and helpful in the easy interpretation. The proposed approach is based on artificial cell swarm optimization and will be known as the SUFACSO (SUperpixel based Fuzzy Artificial Cell Swarm Optimization) and implemented in the Matlab environment. The proposed approach uses a novel superpixel computation method which is helpful to effectively represent the pixel intensity information which is beneficial for the optimization process. Superpixels are further clustered using the proposed fuzzy artificial cell swarm optimization approach. So, a twofold contribution can be observed in this work which is helpful to quickly diagnose the patients in an unsupervised manner so that, the suspected persons can be isolated at an early phase to combat the spread of the COVID-19 virus and it is the major clinical impact of this work. Both qualitative and quantitative experimental results show the effectiveness of the proposed approach and also establish it as an effective computer-aided tool to fight against the COVID-19 virus. Four well-known cluster validity measures Davies-Bouldin, Dunn, Xie-Beni, and ß index are used to quantify the segmented results and it is observed that the proposed approach not only performs well but also outperforms some of the standard approaches. On average, the proposed approach achieves 1.709792, 1.473037, 1.752433, 1.709912 values of the Xie-Beni index for 3, 5,7, and 9 clusters respectively and these values are significantly lesser compared to the other state-of-the-art approaches. The general direction of this research is worthwhile pursuing leading, eventually, to a contribution to the community.
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Coronavirus disease 2019 or COVID-19 is one of the biggest challenges which are being faced by mankind. Researchers are continuously trying to discover a vaccine or medicine for this highly infectious disease but, proper success is not achieved to date. Many countries are suffering from this disease and trying to find some solution that can prevent the dramatic spread of this virus. Although the mortality rate is not very high, the highly infectious nature of this virus makes it a global threat. RT-PCR test is the only means to confirm the presence of this virus to date. Only precautionary measures like early screening, frequent hand wash, social distancing use of masks, and other protective equipment can prevent us from this virus. Some researches show that the radiological images can be quite helpful for the early screening purpose because some features of the radiological images indicate the presence of the COVID-19 virus and therefore, it can serve as an effective screening tool. Automated analysis of these radiological images can help the physicians and other domain experts to study and screen the suspected patients easily and reliably within the stipulated amount of time. This method may not replace the traditional RT-PCR method for detection but, it can be helpful to filter the suspected patients from the rest of the community that can effectively reduce the spread in the of this virus. A novel method is proposed in this work to segment the radiological images for the better explication of the COVID-19 radiological images. The proposed method will be known as SuFMoFPA (Superpixel based Fuzzy Modified Flower Pollination Algorithm). The type 2 fuzzy clustering system is blended with this proposed approach to get the better-segmented outcome. Obtained results are quite promising and outperforming some of the standard approaches which are encouraging for the practical uses of the proposed approach to screening the COVID-19 patients.
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Computer-aided radiological image interpretation systems can be helpful to reshape the overall workflow of the COVID-19 diagnosis process. This article describes an unsupervised CT scan image segmentation approach. This approach begins by performing a morphological reconstruction operation that is useful to remove the effect of the external disturbances on the infected regions and to locate different regions of interest precisely. The optimal size of the structuring element is selected using the Edge Content-based contrast matrix approach. After performing the opening by using the morphological reconstruction operation, further noise is eliminated using the closing-based morphological reconstruction operation. The original pixel space is restored and the obtained image is divided into some non-overlapping smaller blocks and the mean intensity value for each block is computed that is used as the local threshold value for the binarization purpose. It is preferable to manually determine the range of the infected region. If a region is greater than the upper bound then that region will be considered as an exceptional region and processed separately. Three standard metrics MSE, PSNR, and SSIM are used to quantify the outcomes. Both quantitative and qualitative comparisons prove the efficiency and real-life adaptability of this approach. The proposed approach is evaluated with the help of 400 different images and on average, the proposed approach achieves MSE 307.1888625, PSNR 23.7246505, and SSIM 0.831718459. Moreover, the comparative study shows that the proposed approach outperforms some of the standard methods and obtained results are encouraging to support the battle against the COVID-19.
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The absence of dedicated vaccines or drugs makes the COVID-19 a global pandemic, and early diagnosis can be an effective prevention mechanism. RT-PCR test is considered as one of the gold standards worldwide to confirm the presence of COVID-19 infection reliably. Radiological images can also be used for the same purpose to some extent. Easy and no contact acquisition of the radiological images makes it a suitable alternative and this work can help to locate and interpret some prominent features for the screening purpose. One major challenge of this domain is the absence of appropriately annotated ground truth data. Motivated from this, a novel unsupervised machine learning-based method called SUFMACS (SUperpixel based Fuzzy Memetic Advanced Cuckoo Search) is proposed to efficiently interpret and segment the COVID-19 radiological images. This approach adapts the superpixel approach to reduce a large amount of spatial information. The original cuckoo search approach is modified and the Luus-Jaakola heuristic method is incorporated with McCulloch's approach. This modified cuckoo search approach is used to optimize the fuzzy modified objective function. This objective function exploits the advantages of the superpixel. Both CT scan and X-ray images are investigated in detail. Both qualitative and quantitative outcomes are quite promising and prove the efficiency and the real-life applicability of the proposed approach.
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In this work, a new unsupervised classification approach is proposed for the biomedical image segmentation. The proposed method will be known as Fuzzy Electromagnetism Optimization (FEMO). As the name suggests, the proposed approach is based on the electromagnetism-like optimization (EMO) method. The EMO method is extended, modified, and combined with the modified type 2 fuzzy C-Means algorithm to improve its efficiency especially for biomedical image segmentation. The proposed FEMO method uses fuzzy membership and the electromagnetism-like optimization method to locate the optimal positions for the cluster centers. The proposed FEMO approach does not have any dependency on the initial selection of the cluster centers. Moreover, this method is suitable for the biomedical images of different modalities. This method is compared with some standard metaheuristics and evolutionary methods (e.g. Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Electromagnetism-like optimization (EMO), Ant Colony Optimization (ACO), etc.) based image segmentation approaches. Four different indices Davies-Bouldin, Xie-Beni, Dunn and ß index are used for the comparison and evaluation purpose. For the GA, PSO, ACO, EMO and the proposed FEMO approach, the optimal average value of the Davies-Bouldin index is 1.833578359 (8 clusters), 1.669359475 (3 clusters), 1.623119284 (3 clusters), 1.647743907 (4 clusters) and 1.456889343 (3 clusters) respectively. It shows that the proposed approach can efficiently determine the optimal clusters. Moreover, the results of the other quantitative indices are quite promising for the proposed approach compared to the other approaches The detailed comparison is performed in both qualitative and quantitative manner and it is found that the proposed method outperforms some of the existing methods concerning some standard evaluation parameters.
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Microscopic image analysis is one of the challenging tasks due to the presence of weak correlation and different segments of interest that may lead to ambiguity. It is also valuable in foremost meadows of technology and medicine. Identification and counting of cells play a vital role in features extraction to diagnose particular diseases precisely. Different segments should be identified accurately in order to identify and to count cells in a microscope image. Consequently, in the current work, a novel method for cell segmentation and identification has been proposed that incorporated marking cells. Thus, a novel method based on cuckoo search after pre-processing step is employed. The method is developed and evaluated on light microscope images of rats' hippocampus which used as a sample for the brain cells. The proposed method can be applied on the color images directly. The proposed approach incorporates the McCulloch's method for lévy flight production in cuckoo search (CS) algorithm. Several objective functions, namely Otsu's method, Kapur entropy and Tsallis entropy are used for segmentation. In the cuckoo search process, the Otsu's between class variance, Kapur's entropy and Tsallis entropy are employed as the objective functions to be optimized. Experimental results are validated by different metrics, namely the peak signal to noise ratio (PSNR), mean square error, feature similarity index and CPU running time for all the test cases. The experimental results established that the Kapur's entropy segmentation method based on the modified CS required the least computational time compared to Otsu's between-class variance segmentation method and the Tsallis entropy segmentation method. Nevertheless, Tsallis entropy method with optimized multi-threshold levels achieved superior performance compared to the other two segmentation methods in terms of the PSNR.