RESUMEN
The present study was aimed to study the effects of different doses of atorvastatin on Co Q10 content in the myocardium tissue in rats. A subcutaneous injection of isoproterenol (5 mg/kg/day) for 10 days was used for the induction of heart failure. Rats were randomly assigned to control, treatment with atorvastatin (5, 10, 20 mg/kg/day) and treatment with atorvastatin plus coenzyme Q10 (10 mg/kg/day). Coenzyme Q10 content of myocardium was measured using HPLC method with UV detector after hemodynamic parameters measurements. The malondialdehyde (MDA) content of the myocardium was evaluated in order to determine coenzyme Q10 antioxidative effect. A high dose of atorvastatin (20 mg/kg/day) was significantly reduced the myocardium content of coenzyme Q10 as compared with isoproterenol treated group (p<0.001). Compared with atorvastatin alone treated animals, co-administration of coenzyme Q10 with atorvastatin was improved the level of coenzyme Q10 in the myocardium (p<0.05, p<0.001). Increasing the dose of atorvastatin also led to increase in MDA content of the myocardium (p<0.01). Serum lipid profile showed no changes in atorvastatin treated groups. The results of this study demonstrate that high doses of atorvastatin reduce coenzyme Q10 content of the myocardium and increase lipid peroxidation in myocardium which is reversed by coenzyme Q10 co-administration.
Asunto(s)
Insuficiencia Cardíaca/tratamiento farmacológico , Insuficiencia Cardíaca/metabolismo , Ácidos Heptanoicos/farmacología , Isoproterenol/farmacología , Miocardio/metabolismo , Pirroles/farmacología , Ubiquinona/análogos & derivados , Animales , Antioxidantes/farmacología , Atorvastatina , Insuficiencia Cardíaca/sangre , Insuficiencia Cardíaca/inducido químicamente , Peroxidación de Lípido/efectos de los fármacos , Lípidos/sangre , Masculino , Malondialdehído/metabolismo , Ratas , Ratas Wistar , Ubiquinona/metabolismoRESUMEN
This study assessed the effect of an educational intervention (interactive group discussion) on the prescribing behaviour of 51 general physicians from the north-west of Tabriz. Prescriptions were analysed pre-intervention and post-intervention (control and intervention groups) using a proforma with 8 indicators of correct prescribing. The mean number of drugs per prescription pre-intervention was 3.82. The percentage of prescriptions with antibiotics, corticosteroids and injections were 40.8%, 25.9% and 58.0%, respectively. Following the intervention there were slight but not significant changes in the indicators in both intervention and control groups compared with pre-intervention results.
Asunto(s)
Actitud del Personal de Salud , Prescripciones de Medicamentos/estadística & datos numéricos , Educación Médica Continua/organización & administración , Médicos de Familia , Pautas de la Práctica en Medicina/estadística & datos numéricos , Análisis de Varianza , Distribución de Chi-Cuadrado , Países en Desarrollo , Utilización de Medicamentos/estadística & datos numéricos , Grupos Focales , Reforma de la Atención de Salud , Conocimientos, Actitudes y Práctica en Salud , Mal Uso de los Servicios de Salud/estadística & datos numéricos , Humanos , Irán , Evaluación de Necesidades , Selección de Paciente , Médicos de Familia/educación , Médicos de Familia/organización & administración , Médicos de Familia/psicología , Guías de Práctica Clínica como Asunto , Evaluación de Programas y Proyectos de SaludRESUMEN
This study assessed the effect of an educational intervention [interactive group discussion] on the prescribing behaviour of 51 general physicians from the north-west of Tabriz. Prescriptions were analysed pre-intervention and post-intervention [control and intervention groups] using a proforma with 8 indicators of correct prescribing. The mean number of drugs per prescription pre-intervention was 3.82. The percentage of prescriptions with antibiotics, corticosteroids and injections were 40.8%, 25.9% and 58.0%, respectively. Following the intervention there were slight but not significant changes in the indicators in both intervention and control groups compared with pre-intervention results