RESUMEN

Susceptibility to severe influenza A/H1N1pdm09 virus is multifactorial. The present study was carried out in 246 patients infected with A/H1N1pdm09 virus to find out whether single nucleotide polymorphisms (SNPs) in the genes coding for proinflammatory and anti-inflammatory cytokines are associated with disease severity. Among the cases, 129 had mild disease, whereas 117 had severe disease. There were 27 fatal cases. TNFA rs1800629, IFNG rs2430561, IL10 rs1800872, IL10 rs1800896, and CCL2 rs1024611 SNPs were genotyped by polymerase chain reaction-based methods. A significantly higher frequency of TNFA rs1800629 "G/A" genotype was observed in severe and fatal cases compared with mild and survived cases, respectively. In a dominant mode, IL10 rs1800896 "G" allele was significantly negatively associated with disease severity. IL10 rs1800896 "C/A" genotype was significantly associated with fatality in influenza A/H1N1pdm09 infections. The results suggest that SNPs in the IL10 and TNFA genes might be associated with disease severity in influenza A/H1N1pdm09-infected patients.

Asunto(s)

Predisposición Genética a la Enfermedad , Subtipo H1N1 del Virus de la Influenza A/inmunología , Gripe Humana/mortalidad , Interleucina-10/genética , Factor de Necrosis Tumoral alfa/genética , Adolescente , Adulto , Alelos , Femenino , Frecuencia de los Genes/inmunología , Técnicas de Genotipaje , Humanos , India/epidemiología , Subtipo H1N1 del Virus de la Influenza A/aislamiento & purificación , Gripe Humana/genética , Gripe Humana/inmunología , Gripe Humana/virología , Interleucina-10/inmunología , Masculino , Persona de Mediana Edad , Polimorfismo de Nucleótido Simple/inmunología , Índice de Severidad de la Enfermedad , Análisis de Supervivencia , Factor de Necrosis Tumoral alfa/inmunología , Adulto Joven