RESUMEN
Data on the development of three experimental models of hemorrhagic stroke in mice are reported. The models differ in the extent of damage. From the standpoint of the immunopharmacological investigation, most adequate model is provided by the light acute brain circulation disorder (LABCD). In the LABCD model, the hemorrhagic stroke is characterized by reduction in the thymus weight, inhibition of the antibody (hemolysin) synthesis, and enhancement of the delayed type hypersensitivity response. The new antistroke drug cerebral decreased (especially after intranasal administration) the level of lethality in experimental animals and improved the immunological indices.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Hemorragia Cerebral/inmunología , Sistema Inmunológico/efectos de los fármacos , Accidente Cerebrovascular/inmunología , Animales , Formación de Anticuerpos/efectos de los fármacos , Hemorragia Cerebral/etiología , Femenino , Hipersensibilidad Tardía/tratamiento farmacológico , Masculino , Ratones , Accidente Cerebrovascular/complicacionesRESUMEN
The action of the cholinesterase reactivator isonitrosine on gas homeostasis was studied in experiments on intact dogs. It has been found that oxygen consumption and CO2 release by tissues were enhanced within the period from 15 min to 6 days following isonitrosine administration. Simultaneously, oxygen return by the blood was improved. Such action of isonitrosine was unrelated to its effect on the cholinesterase activity of red blood cells.
Asunto(s)
Butanonas/farmacología , Reactivadores de la Colinesterasa/farmacología , Homeostasis/efectos de los fármacos , Intercambio Gaseoso Pulmonar/efectos de los fármacos , Animales , Dióxido de Carbono/sangre , Perros , Relación Dosis-Respuesta a Droga , Pulmón/efectos de los fármacos , Pulmón/metabolismo , Oxígeno/sangre , Consumo de Oxígeno/efectos de los fármacos , Factores de TiempoRESUMEN
Interaction of phosphatidyl choline liposomes with erythrocytes during spontaneous lysis of the latter has been studied. It is shown that hemoglobin which is released during the lysis of erythrocytes is found by liposomes which in their turn are absorbed on the external erythrocyte surface. In this case the binding of hemoglobin by liposomes takes place with a greater speed than its release during erythrocyte lysis and is accompanied by a change in its conformation. Possibilities of the microcalorimetry methods for studying the interaction of liposomes with erythrocytes under the conditions mentioned above are considered.