RESUMEN
The hypothesis that plasma lipids may modulate the antihypertensive effect of the calcium antagonist isradipine was tested in 85 patients who had essential hypertension. Significant linear correlations were found between the antihypertensive effect of isradipine and plasma levels of total cholesterol and high-density lipoprotein (HDL2 or HDL3) in normotriglyceridemic (n = 63), but not in hypertriglyceridemic (n = 22), patients. From this, we conclude that normal levels of plasma lipids may modulate the function of calcium channels and their interaction with calcium antagonists.
Asunto(s)
Colesterol/sangre , Hipertensión/tratamiento farmacológico , Isradipino/uso terapéutico , Triglicéridos/sangre , Adulto , Anciano , Presión Sanguínea/efectos de los fármacos , Humanos , Hiperlipidemias/sangre , Hiperlipidemias/complicaciones , Hipertensión/sangre , Hipertensión/complicaciones , Isradipino/farmacología , Modelos Lineales , Persona de Mediana Edad , Resultado del TratamientoAsunto(s)
Creatina Quinasa/análisis , Infarto del Miocardio/enzimología , Adulto , Anciano , Femenino , Humanos , Isoenzimas , Masculino , Persona de Mediana Edad , PronósticoRESUMEN
A study was carried out to evaluate the long-term effects and side-effects of a combination product containing the beta-blocker pindolol (10 mg) and the diuretic clopamide (5 mg) in 15 patients with moderate hypertension. All patients completed the 2-years' study. The dose of the combination was increased until blood pressure normalized or a maximum dose of 3 tablets (equivalent to 30 mg pindolol and 15 mg clopamide) daily was reached. Blood pressure and heart rate were recorded monthly and detailed medical examinations were done regularly throughout the study. A mean dose of 2 tablets of the combination product (20 mg pindolol and 10 mg clopamide) produced a significant reduction in blood pressure. In all but 1 patient, blood pressure control was achieved and maintained. No tolerance developed. Heart volume showed a marked decrease. No side-effects of clinical importance were noted.
Asunto(s)
Clopamida/uso terapéutico , Hipertensión/tratamiento farmacológico , Pindolol/uso terapéutico , Adulto , Presión Sanguínea/efectos de los fármacos , Combinación de Medicamentos , Electrocardiografía , Femenino , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Placebos , Potasio/sangre , Factores de TiempoRESUMEN
Authors using D.C. (direct current)--have produced shock experimentally- at 28 dogs. In the control animals (8 dogs) no histological, EKG and enzymatic changes could be revealed. In the dogs after the application of D.C of 1 X 2.5 W. sec/kg histological and EKG changes were not revealed, although the level of GOT and CPK increased significantly. After the application of D.C. of 4 X 5 W. sec/kg significant increase of the level of the following enzymes occurred: GOT, isoenzyme- LDH5, total-LDH and CPK. In 7 dogs--out of 8 showing histological changes in the myocard--activity of the serum isoenzyme-LDH1 increased and alterations of the EKG occurred. Thoracic musculature of six experimental dogs was investigated histologically. All of them revealed pathological changes. Correlation between the level of the isoenzyme- LDH1, the histological and EKG alterations were found. Increase of the level of serum enzymes seems to be the consequence of the injury of the thoracic-musculature by D.C. shock, and has clinical significance only in cases when pathologic changes of the EKG and increase of the insoenzyme-LDH1 are also present.
Asunto(s)
Electrochoque , Miocardio/enzimología , Animales , Perros , Electrocardiografía , Enzimas/sangre , Corazón/fisiología , Músculos/enzimología , Músculos/patología , Miocardio/patología , Tórax/fisiologíaRESUMEN
Local blood flow of the hypothalamus (HBF) was measured by the hydrogen clearance method in anaesthetized dogs. The average value for HBF in normal controls was 0.64 +/- 0.05 ml/g/min, which compares favourably with values available in the literature. During haemorrhagic hypotension induced by a modified Wiggers method there occurred a marked reduction of HBF to 52% of the initial control value at a mean arterial blood pressure (MABP) of 55--60 mm Hg and to 44% at 35--40 mm Hg. Prevention of concomitant extracellular acidosis by infusion of sodium bicarbonate solution during the hypotensive period resulted in a significantly smaller decrease in HBF as compared to an untreated control group, and a significant protection of HBF was also found at 55--60 mm Hg MABP in the bicarbonate treated group, but not in controls treated with physiologic saline. Hypothalamic tissue hypoxia was inevitable in untreated bled animals due to insufficient circulatory transport, while evidence suggested that the metabolism might have remained unaltered in the group protected against acidosis during haemorrhage. Analysis of the control of local hypothalamic blood flow revealed a significant correlation (r = 0.7026, p less than 0.001) between HBF and arterial blood pH in severe hypotension which is outside the autoregulatory blood pressure domain.