RESUMEN

Idiopathic thrombocytopenic purpura in children 10 years of age or younger was observed to have a more favorable prognosis than in older children. Corticosteroid therapy in children judged to be at increased risk of serious hemorrhage resulted in a significantly greater number of patients with an early increase in platelets than was noted in a control group. All patients with chronic disease who responded to administration of a corticosteroid initially and then relapsed had some response to a subsequent course of therapy, although none had a sustained remission. In such patients, splenectomy was a more effective therapeutic measure than treatment with either a corticosteroid or a cytotoxic agent.

Asunto(s)

Corticoesteroides/uso terapéutico , Hemorragia/prevención & control , Inmunosupresores/uso terapéutico , Púrpura Trombocitopénica/terapia , Adolescente , Corticoesteroides/sangre , Hormona Adrenocorticotrópica/administración & dosificación , Hormona Adrenocorticotrópica/uso terapéutico , Factores de Edad , Azatioprina/efectos adversos , Azatioprina/uso terapéutico , Plaquetas/análisis , Niño , Preescolar , Cortisona/uso terapéutico , Femenino , Hemorragia/tratamiento farmacológico , Hemorragia/etiología , Hemostasis , Humanos , Lactante , Masculino , Metilprednisolona/uso terapéutico , Prednisona/uso terapéutico , Púrpura Trombocitopénica/sangre , Púrpura Trombocitopénica/complicaciones , Estaciones del Año , Esplenectomía